A5021724996- Hepatitis B Virus Studies
- Cytokine Signaling Pathways and Interactions
- Ion channel regulation and function
- Nerve injury and regeneration
- Spinal Cord Injury Research
- Reproductive System and Pregnancy
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Cell Adhesion Molecules Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Prenatal Substance Exposure Effects
- Heat shock proteins research
- Seaweed-derived Bioactive Compounds
- Protease and Inhibitor Mechanisms
- Adenosine and Purinergic Signaling
- Genetics and Neurodevelopmental Disorders
- Neurological Disease Mechanisms and Treatments
- Periodontal Regeneration and Treatments
- Signaling Pathways in Disease
- Liver Disease Diagnosis and Treatment
- Pain Mechanisms and Treatments
- Osteoarthritis Treatment and Mechanisms
- Phytochemicals and Antioxidant Activities
- Immune cells in cancer
- Cell death mechanisms and regulation
Konkuk University
2010-2020
Chung-Ang University
2020
Konkuk University Medical Center
2008-2016
Chungnam National University
2008
University of Pittsburgh Medical Center
2008
The nonobese diabetic (NOD) mouse is a classical animal model for autoimmune type 1 diabetes (T1D), closely mimicking features of human T1D. Thus, the NOD presents an opportunity to test effectiveness induced pluripotent stem cells (iPSCs) as therapeutic modality Here, we demonstrate proof concept cellular therapy using mouse-derived iPSCs (NOD-iPSCs). We generated from embryonic fibroblasts or pancreas-derived epithelial (NPEs), and applied directed differentiation protocols differentiate...
Preconception exposure to EtOH through the paternal route may affect neurobehavioral and developmental features of offspring. This study investigates effects before conception on hyperactivity, inattention, impulsivity behavior male offspring in mice. Sire mice were treated with a concentration range approximating human binge drinking (0–4 g/kg/day EtOH) for 7 weeks mated untreated females produce sire induced attention deficit hyperactivity disorder (ADHD)‐like hyperactive, inattentive,...
Cancer is one of the highly virulent diseases known to humankind with a high mortality rate. Breast cancer most common in women worldwide. Sorghum principal cereal food many parts world, and critical folk medicine Asia Africa. In present study, we analyzed effects HSE metastatic breast cancer.
Objective Interferons (IFNs) mediate direct antiviral activity. They play a crucial role in the early host immune response against viral infections. However, IFN therapy for HBV infection is less effective than other Design We explored cellular targets of to IFNs using proteome-wide screening. Results Using LC-MS/MS, we identified proteins downregulated and upregulated by treatment X protein (HBx)-stable control cells. found several IFN-stimulated genes HBx, including TRIM22 , which known as...
Abstract Humans process a plethora of sensory information that is provided by various entities in the surrounding environment. Among five major senses, technology for touch, haptics, relatively young and has limited applications largely due to its need physical contact. In this article, we suggest new way non-contact haptic stimulation uses laser , which potential advantages such as mid-air stimulation, high spatial precision long working distance. We demonstrate tactile can be enabled...
Abstract Objective Interleukin‐32 (IL‐32) is a recently discovered cytokine that appears to play critical role in human rheumatoid arthritis (RA). It highly expressed synovium and fibroblast‐like synoviocytes (FLS) from RA patients, but not patients with osteoarthritis (OA). This study was undertaken assess IL‐32 levels synovial fluid (SF) investigate the secretion regulation of FLS. Methods FLS SF were obtained joints patients. The expression activation signaling molecules examined by...
Hepatitis B virus (HBV) infection is one of the major causes hepatocellular carcinoma (HCC) development. X protein (HBx) known to play a key role in development (HCC). Several cellular proteins have been reported be over-expressed HBV-associated HCC tissues, but their HBV-mediated oncogenesis remains largely unknown. Here, we explored effect protein, ribosomal S3a (RPS3a), on HBx-induced NF-κB signaling as critical step for The enhancement by RPS3a was investigated its ability translocate...
Liver regeneration after liver damage caused by toxins and pathogens is critical for homeostasis. Retardation of proliferation was reported in hepatitis B virus (HBV) X protein (HBx)-transgenic mice. However, the underlying mechanism HBx-mediated disturbance unknown. We investigated molecular inhibition using cell lines a mouse model. The model acute HBV infection established hydrodynamic injection viral DNA. partial hepatectomy significantly inhibited DNA-treated Mechanism studies have...
Cytokines are involved in early host defense against pathogen infections. In particular, tumor necrosis factor (TNF) and interferon-gamma (IFN-γ) have critical functions non-cytopathic elimination of hepatitis B virus (HBV) hepatocytes. However, the molecular mechanisms mediator molecules largely unknown. Here we show that interleukin-32 (IL-32) is induced by TNF IFN-γ hepatocytes, inhibits replication HBV acting intracellularly to suppress transcription replication. The gamma isoform IL-32...
The role of apurinic/apyrimidinic endonuclease-1/redox factor-1 (Ref-1) in vascular smooth muscle cells has yet to be clearly elucidated. Therefore, we attempted determine the roles Ref-1 migration induced by platelet-derived growth factor (PDGF)-BB and its signaling rat aortic (RASMCs). Cellular migration, superoxide (O 2 −· ) production, Rac-1 activity, neointima formation were determined transfected with adenoviruses encoding for (AdRef-1) small interference RNA Ref-1. Overexpression...
Presently, few treatments for spinal cord injury (SCI) are available and none have facilitated neural regeneration and/or significant functional improvement. Agmatine (Agm), a guanidinium compound formed from decarboxylation of L-arginine by arginine decarboxylase, is neurotransmitter/neuromodulator been reported to exert neuroprotective effects in central nervous system models including SCI. The purpose this study was demonstrate the multifaceted Agm on recovery remyelinating events...
In the current investigation, status of septo-hippocampal cholinergic pathway and hippocampal mitogen-activated protein kinase (MAPK) signaling was examined in male Wistar rats with chronic cerebral hypoperfusion, which showed cognitive deficits based on assessment a version Morris water maze. Chronic hypoperfusion induced by bilateral common artery occlusion maintained for 12 weeks until behavioral testing. shown to induce memory impairments microglial activation regions white matter,...
J. Neurochem. (2012) 123, 226-238.Fragile X syndrome (FXS), the most common single genetic cause of mental retardation and autistic spectrum disease, occurs when FMR1 gene is mutated. encodes fragile protein (FMRP) which regulates translation mRNAs playing important roles in development neurons as well formation maintenance synapses. To examine whether FMRP cell viability, we induced apoptosis rat primary cortical with glutamate vitro middle cerebral artery occlusion (MCAO) striatal vivo....
The aim of our study was to determine the difference cellular prion protein (PrP(C)) expression in placentas women with normal and preeclamptic pregnancies.Retrospective using banked placental tissue samples.University hospital.Twenty severe preeclampsia (preeclampsia group) 20 gestational age-matched normotensive (normal group).Placental from each woman collected at time cesarean section.Quantitative reverse transcription polymerase chain reaction (RT-PCR), western blot analysis,...
Intended to investigate whether agmatine treatment reduces collagen scar area in mice subjected spinal cord injury (SCI).The purpose of the present study is demonstrate protective effect on complete transection SCI mice. SUMMARY OF BACK GROUND DATA: The deposition that occurs at lesion site, during SCI, was well known. Agmatine has been reported exert neuroprotective various stress models including central nervous system injuries. In investigation, we hypothesized could rescue SCI.Complete...