A5036695624- Neuroinflammation and Neurodegeneration Mechanisms
- Protease and Inhibitor Mechanisms
- Nerve injury and regeneration
- Histone Deacetylase Inhibitors Research
- Natural product bioactivities and synthesis
- Calpain Protease Function and Regulation
- Neuroscience and Neuropharmacology Research
- Phytochemistry and Biological Activities
- Signaling Pathways in Disease
- Neurological Disease Mechanisms and Treatments
- Pharmacological Effects of Natural Compounds
- Autism Spectrum Disorder Research
- Anesthesia and Neurotoxicity Research
- Parkinson's Disease Mechanisms and Treatments
- Adenosine and Purinergic Signaling
- S100 Proteins and Annexins
- Epigenetics and DNA Methylation
- Nitric Oxide and Endothelin Effects
- Electrolyte and hormonal disorders
- Medicinal Plants and Neuroprotection
- Child Welfare and Adoption
- Autophagy in Disease and Therapy
- Hippo pathway signaling and YAP/TAZ
- Ziziphus Jujuba Studies and Applications
- Ginseng Biological Effects and Applications
Woosuk University
2017-2025
Konkuk University
2009-2022
Konkuk University Medical Center
2014
Preconception exposure to EtOH through the paternal route may affect neurobehavioral and developmental features of offspring. This study investigates effects before conception on hyperactivity, inattention, impulsivity behavior male offspring in mice. Sire mice were treated with a concentration range approximating human binge drinking (0–4 g/kg/day EtOH) for 7 weeks mated untreated females produce sire induced attention deficit hyperactivity disorder (ADHD)‐like hyperactive, inattentive,...
We investigated the immune-regulatory function of quercetin, in interleukin (IL)-17-produced osteoclastogenesis rheumatoid arthritis (RA). RA fibroblasts-like synoviocytes (RA-FLS) were stimulated with IL-17, and mRNA expression secretion receptor activator nuclear factor kappa-B ligand (RANKL) detected by real-time polymerase chain reaction enzyme-linked immunosorbent assay, respectively. CD14+ monocytes (osteoclast precursors) RANKL, with/without tartrate-resistant acid phosphatase...
Neuroinflammation promotes the progression of various neurological and neurodegenerative diseases. Disrupted homeostasis protein acetylation is implicated in neurodegeneration, lysine acetyltransferase GCN5 (also known as KAT2A) peripheral inflammation. Here, we investigated whether plays a role neuroinflammation brain. Systemic administration bacterial molecule LPS mice to induce inflammation increased abundance organs, including brain specifically microglia. In response LPS, mediated...
Abnormally upregulated cholesterol and lipid metabolism, observed commonly in multiple cancer types, contributes to development progression through the activation of oncogenic growth signaling pathways. Although accumulating evidence has shown preventive therapeutic benefits cholesterol-lowering drugs for management, is needed treatment as well metabolism-related chronic diseases. Ursolic acid (UA), a natural pentacyclic terpenoid, suppresses metastasis, but precise underlying molecular...
Microglia activation and the release of various inflammatory cytokines are largely related to neurological diseases, including Parkinson's, Alzheimer's, other brain diseases. The suppression microglial cells using natural bioactive compounds has become increasingly important for therapy owing expected beneficial effect lower toxicity. Scoparone (6,7-dimethoxycoumarin), a major compound found in plant parts, inner shell chestnut (Castanea crenata), was evaluated on lipopolysaccharide...
Parkinson's disease (PD) is a commonly reported age-related neurodegenerative disorder. Microglial-mediated neuroinflammation one of the cardinal hallmarks various disorders, including PD progression. Inadequate therapeutic strategies and substantial adverse effects well-established drug candidates demand new leads to treat PD. Dendropanax morbifera (DM) an endemic plant species South Korea, it has been used extensively as traditional medicine numerous clinical complications. In this study,...
Zerumbone (ZER), an active constituent of the Zingiberaceae family, has been shown to exhibit several biological activities, such as anti-inflammatory, anti-allergic, anti-microbial, and anti-cancer; however, it not studied for anti-melanogenic properties. In present study, we demonstrate that ZER Zingiber officinale (ZO) extract significantly attenuate melanin accumulation in α-melanocyte-stimulating hormone (α-MSH)-stimulated mouse melanogenic B16F10 cells. Further, elucidate molecular...
Tissue plasminogen activator (tPA) is expressed in several regions of brain and plays regulatory roles such as neurite outgrowth, synaptic plasticity long term potentiation. The activity tPA regulated by an endogenous inhibitor inhibitor‐1 (PAI‐1), which mainly astrocytes. Valproic acid (VPA), a histone deacetylase that used for the treatment epilepsy bipolar disorders, promotes extension, neuronal growth has neuroprotective effect neurodegenerative diseases. In this study, we examined...
The R132H mutation in isocitrate dehydrogenase 1 (IDH1R132H) is commonly observed and associated with better survival glioblastoma multiforme (GBM), a malignant brain tumor. However, the functional role of IDH1R132H as molecular target for GBM treatment not completely understood. In this study, we found that overexpression suppresses cell growth, cycle progression motility U87MG cells. Based on viability apoptosis assays, IDH1R132H-overexpressing U373MG cells are resistant to anti-cancer...
Glial cells are the resident immune of central nervous system. Reactive glial release inflammatory mediators that induce neurotoxicity or aggravate neurodegeneration. Regulation activation is crucial for initiation and progression neuropathological conditions. Constituents peach tree (Prunus persica L. Batsch), which has a global distribution, have been found to exert therapeutic effects in pathological conditions, such as rashes, eczema allergies. However, potential its aerial parts...
Autism spectrum disorders (ASDs) are neurodevelopmental that share behavioral features, the results of numerous studies have suggested underlying causes ASDs multifactorial. Behavioral and/or neurobiological analyses been performed extensively using a valid model prenatal exposure to valproic acid (VPA). Abnormal synapse formation resulting from altered neurite outgrowth in neural progenitor cells (NPCs) during embryonic brain development has observed both VPA and ASD subjects. Although...