A5010961981- Neuroinflammation and Neurodegeneration Mechanisms
- Medicinal Plants and Neuroprotection
- Alzheimer's disease research and treatments
- Marine Sponges and Natural Products
- Microbial Natural Products and Biosynthesis
- Bioactive Compounds and Antitumor Agents
- Parkinson's Disease Mechanisms and Treatments
- Natural product bioactivities and synthesis
- Histone Deacetylase Inhibitors Research
- Bee Products Chemical Analysis
- Autophagy in Disease and Therapy
- Ginseng Biological Effects and Applications
- Neuroscience and Neuropharmacology Research
- Healthcare and Venom Research
- Synthesis and biological activity
- Phytochemistry and Biological Activities
- Nerve injury and regeneration
- Seaweed-derived Bioactive Compounds
- Cholinesterase and Neurodegenerative Diseases
- Adenosine and Purinergic Signaling
- Pharmacological Effects of Natural Compounds
- Hops Chemistry and Applications
- Immune cells in cancer
- Nigella sativa pharmacological applications
- Synthesis of β-Lactam Compounds
Konkuk University
2016-2025
Neuroinflammation promotes the progression of various neurological and neurodegenerative diseases. Disrupted homeostasis protein acetylation is implicated in neurodegeneration, lysine acetyltransferase GCN5 (also known as KAT2A) peripheral inflammation. Here, we investigated whether plays a role neuroinflammation brain. Systemic administration bacterial molecule LPS mice to induce inflammation increased abundance organs, including brain specifically microglia. In response LPS, mediated...
Abstract The Salicornia europaea L . (SE) plant is a halophyte that has been widely consumed as seasoned vegetable, and it recently reported to counteract chronic diseases related oxidative inflammatory stress. In this study, we performed an initial phytochemical analysis with in vitro biochemical tests chromatographic profiling of desalted enzyme-digested SE ethanol extract (SE-EE). Subsequently, evaluated the anti-neuroinflammatory ameliorative potential SE-EE LPS-inflicted BV-2 microglial...
Microglia activation and the release of various inflammatory cytokines are largely related to neurological diseases, including Parkinson's, Alzheimer's, other brain diseases. The suppression microglial cells using natural bioactive compounds has become increasingly important for therapy owing expected beneficial effect lower toxicity. Scoparone (6,7-dimethoxycoumarin), a major compound found in plant parts, inner shell chestnut (Castanea crenata), was evaluated on lipopolysaccharide...
The proton-activated G protein-coupled receptor (GPCR) 4 (GPR4) is constitutively active at physiological pH, and GPR4 knockout protected dopaminergic neurons from caspase-dependent mitochondria-associated apoptosis. This study explored the role of in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mouse model Parkinson’s disease (PD). In mice, subchronic MPTP administration causes oxidative stress-induced apoptosis substantia nigra pars compacta (SNpc), resulting motor...
Cognitive decline and memory impairment induced by oxidative brain damage are the critical pathological hallmarks of Alzheimer's disease (AD). Based on potential neuroprotective effects AD-1 small molecule, we here explored possible underlying mechanisms protective effect molecule against scopolamine-induced stress, neuroinflammation, neuronal apoptosis. According to our findings, scopolamine administration resulted in increased AChE activity, MDA levels, decreased antioxidant enzymes, as...
Neuroinflammation, apoptosis, and oxidative stress are connected to the pathogenesis of neurodegenerative diseases (NDDs). Targeting these three factors, intervention neuroprotective agents may have great potential in treatment NDDs. In current study, anti-inflammatory effects methanol extract Allium cepa (MEAC) lipopolysaccharide (LPS)-induced BV-2 microglial cells were investigated. MEAC has been studied regard regulation antiapoptotic gene (Bcl-2) various antioxidant enzyme (HO-1, NQO-1,...
<title>Abstract</title> <bold>Background: </bold>Apitoxin<sup>®</sup>, a drug based on bee venom was approved and released in Korea 2003 as the Ethical (ETC). It is well-known for its pain-relieving properties due to potent anti-inflammatory effects. This raises question of whether has benefits other inflammatory disorders. Since effectiveness treating inflammation pain associated with autoimmune diseases been observed several clinical cases Korea, we conducted an efficacy using animal model...
Apitoxin®, a drug based on bee venom was approved and released in Korea 2003 as the ethical (ETC). It is well-known for its pain-relieving properties due to potent anti-inflammatory effects. This raises question of whether has benefits other inflammatory disorders. Since effectiveness treating inflammation pain associated with autoimmune diseases been observed several clinical cases Korea, we conducted an efficacy study using animal model systemic lupus erythematosus (SLE), disease high...
Parkinson's disease (PD) is a commonly reported age-related neurodegenerative disorder. Microglial-mediated neuroinflammation one of the cardinal hallmarks various disorders, including PD progression. Inadequate therapeutic strategies and substantial adverse effects well-established drug candidates demand new leads to treat PD. Dendropanax morbifera (DM) an endemic plant species South Korea, it has been used extensively as traditional medicine numerous clinical complications. In this study,...
Cognitive impairment and behavioral disparities are the distinctive baseline features to investigate in most animal models of neurodegenerative disease. However, neuronal complications multifactorial demand a suitable model their underlying basal mechanisms. By contrast, numerous existing studies have utilized various strains, leading factual disparity. Choosing an optimal mouse strain for preliminary assessment is therefore imperative. In this study, we systematically compared behavioral,...
Autophagy is a cellular homeostatic process by which cells degrade and recycle their malfunctioned contents, impairment in this could lead to Parkinson's disease (PD) pathogenesis. Dioscin, steroidal saponin, has induced autophagy several cell lines animal models. The role of dioscin-mediated PD remains be investigated. Therefore, study aims investigate the hypothesis that dioscin-regulated autophagy-related (ATG) proteins protect neuronal via reducing apoptosis enhancing neurogenesis. In...
Two new phomaligols, deketo-phomaligol A (1) and phomaligol E (2), together with six known compounds (3-8) were isolated from the culture broth of marine-derived fungus Aspergillus flocculosus. Compound 1 was first as a derivative possessing five-membered ring. The structures absolute configurations phomaligols determined by detailed analyses mass spectrometry (MS), nuclear magnetic resonance (NMR) data, optical rotation values electronic circular dichroism (ECD). In addition, 3 4 confirmed...
A new type of natural products, miharadienes A–D (1–4), was isolated from the marine-derived Streptomyces miharaensis 151KO-143.
The biological characteristics of intestinal-type early gastric cancers (ICs) differ based on mucin phenotypes. Beta-catenin delocalization is a predictive marker aggressive behavior (submucosal invasion and lymph node metastasis) ICs. presumptive causative genetic alterations leading to beta-catenin in ICs are still controversial, there only few reports regarding expression cancer Therefore, the current study, mechanisms were elucidated basis phenotypes 109 cases There was increased...
A series of salicylic acid analogues celecoxib where the phenylsulfonamide moiety in structure is replaced by was synthesized and tested for vitro cyclooxygenase (COX)-1 COX-2 enzyme inhibition. Among series, 5-substituted-2-hydroxy-benzoic (7a-7h) generally showed better inhibitory activities on both enzymes than 4-substituted-2-hydroxy-benzoic (12a-12h). In particular, chloro analogue 7f which had highest effect (IC50 = 0.0057 µM) to COX-1 with excellent selectivity (SI 768) can be...