A5002802312- Histone Deacetylase Inhibitors Research
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Cancer, Lipids, and Metabolism
- Cancer Mechanisms and Therapy
- Circular RNAs in diseases
- Cancer-related gene regulation
- Hepatocellular Carcinoma Treatment and Prognosis
- Extracellular vesicles in disease
- Ubiquitin and proteasome pathways
- RNA Research and Splicing
- Chromatin Remodeling and Cancer
- Mechanisms of cancer metastasis
- Protein Degradation and Inhibitors
- Peptidase Inhibition and Analysis
- Carcinogens and Genotoxicity Assessment
- Sirtuins and Resveratrol in Medicine
- Cancer, Hypoxia, and Metabolism
- Cancer Cells and Metastasis
- Liver Disease Diagnosis and Treatment
- Molecular Biology Techniques and Applications
- Cancer-related Molecular Pathways
Ajou University
2019-2025
Catholic University of Korea
2013-2023
Sungkyunkwan University
2016-2023
University of Ulsan
2019
Asan Medical Center
2019
Ulsan College
2019
Zero to Three
2017
Seoul National University
2010-2014
Medizinische Hochschule Hannover
2012
Korean Association Of Science and Technology Studies
2010
Accumulated evidence has established that aberrant regulation of histone deacetylases (HDACs) is one the major causes development human malignancies. Among different iso‐enzymes HDAC and sirtuins grouped as super family, little known to how deacetylase 2 (HDAC2) carcinogenesis in solid tumors. Here, order investigate possible role HDAC2 gastric carcinogenesis, we analyzed expression 71 adenocarcinomas by immunohistochemistry. Moderate strong was found 44 (62%) out a total The majority...
Sirtuins are nicotinamide adenine dinucleotide oxidized form (NAD+)-dependent deacetylases and function in cellular metabolism, stress resistance, aging. For sirtuin7 (SIRT7), a role ribosomal gene transcription is proposed, but its cancer has been unclear. In this study we show that SIRT7 expression was up-regulated large cohort of human hepatocellular carcinoma (HCC) patients. knockdown influenced the cell cycle caused significant increase liver cells to remain G1/S phase suppress growth....
Abstract Background Cancer‐associated fibroblasts (CAFs) play an important role in the induction of chemo‐resistance. This study aimed to clarify mechanism underlying CAF‐mediated resistance two tyrosine kinase inhibitors (TKIs), sorafenib and lenvatinib, identify a novel therapeutic target for overcoming TKI hepatocellular carcinoma (HCC). Methods We performed systematic integrative analysis publicly available gene expression datasets whole‐transcriptome sequencing data from 9 pairs CAFs...
Abstract Histone deacetylase 2 (HDAC2) is crucial for embryonic development, affects cytokine signaling relevant immune responses, and often significantly overexpressed in solid tumors, but little known of its role human lung cancer. In this study, we demonstrated the aberrant expression HDAC2 cancer tissues investigated oncogenic properties cell lines. inactivation resulted regression tumor growth activation cellular apoptosis via p53 Bax Bcl2 suppression. cycle regulation, caused induction...
// Hyung Seok Kim 1,2,* , Kyo Sun Lee 3,* Hyun Jin Bae 1,2 Jung Woo Eun Qingyu Shen Se Park Chan Shin Hee Doo Yang Mijung Won Sang Yong-Koo Kang 3 and Suk Nam 1,2,4 1 Lab of Oncogenomics, Department Pathology, College Medicine, The Catholic University Korea, Seoul, Republic Korea 2 Functional RNomics Research Center, Orthopedic Surgery, Gyeonggi-do, 4 Cancer Evolution * These authors contributed equally to this work Correspondence to: Nam, email: Keywords : Hepatocellular carcinoma,...
An accurate tool enabling early diagnosis of hepatocellular carcinoma (HCC) is clinically important, given that detection HCC markedly improves survival. We aimed to investigate the molecular markers underlying progression can be detected in precancerous lesions. designed a gene selection strategy identify potential driver genes by integrative analysis transcriptome and clinicopathological data human multistage tissues, including lesions, low‐ high‐grade dysplastic nodules. The process was...
Exosomal microRNAs (exo-miRs) have been promising cancer biomarkers. MiRs in hepatocellular carcinoma (HCC) cell-derived exosomes (HEX) were analyzed to identify reliable serum biomarkers for HCC. To detect overexpressed miRs HEX, extracted exosomal small RNAs from human HCC cell lines and normal hepatocytes sequenced analyzed. Clinical significance of the HEX was evaluated using quantitative real-time PCR (qRT-PCR) on samples a validation cohort consisting 28 healthy individuals, 60 with...
Ubiquitin-binding histone deacetylase 6 (HDAC6) is uniquely endowed with tubulin activity and plays an important role in the clearance of misfolded protein by autophagy. In cancer, HDAC6 has become a target for drug development due to its major contribution oncogenic cell transformation. present study we show that expression was down-regulated large cohort human hepatocellular carcinoma (HCC) patients, low significantly associated poor prognosis HCC patients 5-year overall, disease-free,...
Histone deacetylases (HDACs) are known to play a central role in the regulation of several cellular properties interlinked with development and progression cancer. Recently, HDAC1 has been reported be overexpressed hepatocellular carcinoma (HCC), but its biological roles hepatocarcinogenesis remain elucidated. In this study, we demonstrated overexpression subset human HCCs liver cancer cell lines. inactivation resulted regression tumor growth activation caspase-independent autophagic death,...
Histone deacetylase 2 (HDAC2) is crucial for embryonic development, affects cytokine signaling relevant immune responses and often significantly overexpressed in solid tumors; but little known about its role human hepatocellular carcinoma (HCC). In this study, we showed that targeted-disruption of HDAC2 resulted reduction both tumor cell growth de novo DNA synthesis Hep3B cells. We then demonstrated regulated cycle disruption caused G1/S arrest cycle. transition, selectively induced the...
// Hee Doo Yang 1, 3, * , Pum-Joon Kim 2, Jung Woo Eun 3 Qingyu Shen Hyung Seok Chan Shin Young Min Ahn 4 Won Sang Park 1 Lee Suk Nam 5 Laboratory of Oncogenomics, Department Pathology, College Medicine, The Catholic University Korea, Seoul 06591, Republic Korea 2 Cardiology, Functional RNomics Research Center, Kidney System, Oriental Kyung University, 02447, Cancer Evolution These authors contributed equally to this work Correspondence to: Nam, e-mail: swnam@catholic.ac.kr Keywords:...
// Hun-Jun Park 1, * , Ji Heon Noh 2, 3, Jung Woo Eun Yoon-Seok Koh 1 Suk Min Seo Won Sang 2 Young Lee Kiyuk Chang Ki Bae Seung Pum-Joon Kim Nam 4 Department of Cardiology, College Medicine, The Catholic University Korea, Seoul, Republic Korea Pathology, 3 Functional RNomics Research Center, Cancer Evolution These authors have contributed equally to this work Correspondence to: Nam, e-mail: swnam@catholic.ac.kr Kim, bjheart@catholic.ac.kr Keywords: ST-segment-elevation myocardial infarction,...
Histone deacetylase 6 (HDAC6) uniquely serves as a tumor suppressor in hepatocellular carcinogenesis, but the underlying mechanisms leading to suppression are not fully understood. To identify comprehensive microRNAs (miRNAs) regulated by HDAC6 differential miRNA expression analysis of ‐transfected Hep3B cells was performed. Using integrative analyses publicly available transcriptome data and target prediction, we selected five candidate miRNAs and, through vitro functional validation,...
Deregulation of the epigenome component affects multiple pathways in cancer phenotype since acts at pinnacle hierarchy gene expression. Pioneering work over past decades has highlighted that targeting enzymes or proteins involved epigenetic regulation is a valuable approach to therapy. Very recent results demonstrated inhibiting reader BRD4 notable efficacy diverse types. We investigated potential as therapeutic target liver malignancy. was overexpressed three different large cohort...
This study aimed to identify novel long noncoding RNA (lncRNA) biomarkers for hepatocellular carcinoma (HCC) using publicly available tissue genomic datasets and validate their diagnostic utility early‐stage HCC. Differentially expressed lncRNAs between 371 HCC 50 nontumor tissues were obtained from The Cancer Genome Atlas liver (TCGA_LIHC) project. Subsequently, the expression of serum‐ extracellular vesicle (EV)‐derived lncRNA was assessed in 10 patients with healthy controls RT–qPCR....
Abstract Currently, a reliable serum biomarker for hepatocellular carcinoma (HCC) has not been established, particularly early‐stage HCC (single tumor < 2 cm). We aimed to investigate diagnostic exosomal microRNA (exo‐miR) panel HCC. Driver oncogenic miR (onco‐miR) candidates were selected by integrative analysis of expression profiles from three different RNA sequencing datasets human Expressions onco‐miRs in exosome measured using quantitative real‐time PCR. Diagnostic performances...
Aberrant regulation of histone deacetylase 2 (HDAC2) was reported for gastric cancers. However, responsive cancer genes in disease onset and progression are less understood. HDAC2 expression studied by quantitative RT-PCR Western blotting. The functional consequences knockdown on cell-cycle regulation, programmed cell death, gene target identification investigated flow cytometry, blotting, electron microscopy, anchorage-independent colony formation, migration assay whole-genome microarray....
Aberrant regulation of histone deacetylase 2 (HDAC2) contributes to malignant progression in various cancers, but the underlying mechanism leading activation oncogenic HDAC2 remains unknown. In this study, we show that expression is upregulated a large cohort patients with human hepatocellular carcinoma, and high was significantly associated poor prognosis carcinoma. We found mTORC1/NF-κBp50 signaling necessary for growth factor-induced sustained not normal hepatic cells. Growth mTORC1...