A5037984062- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Artificial Intelligence in Healthcare
- Liver Disease and Transplantation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Mechanisms and Therapy
- Organ Transplantation Techniques and Outcomes
- Radiomics and Machine Learning in Medical Imaging
- Cancer, Lipids, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Hepatitis Viruses Studies and Epidemiology
- Immune Cell Function and Interaction
- Liver physiology and pathology
- Cancer, Hypoxia, and Metabolism
- Drug-Induced Hepatotoxicity and Protection
- HIV/AIDS drug development and treatment
- Ferroptosis and cancer prognosis
- Renal Transplantation Outcomes and Treatments
- Immune cells in cancer
- Advanced Radiotherapy Techniques
- Colorectal Cancer Treatments and Studies
- Cancer Cells and Metastasis
- MRI in cancer diagnosis
Catholic University of Korea
2016-2025
Seoul St. Mary's Hospital
2016-2025
Uijeongbu St. Mary's Hospital
2024
Mayo Clinic in Arizona
2018
Gyeongsang National University
2007-2017
Incheon St. Mary's Hospital
2011-2016
Hanyang University
2016
Sungkyunkwan University
2016
Soonchunhyang University
2016
Yonsei University
2016
Abstract Tumor-associated immune response plays a critical role in cancer pathogenesis. This study evaluated clinical implications of T cell cytokines and regulatory cells (Tregs) HCC patients treated with TACE. Whole blood was obtained for analysis (IL-1β, IL-2, IL-4, IL-5, IL-6, IL-9, IL-10, IL-12p70, IL-13, IL-17A, IL-22, IFN-γ, TNF-α) Tregs from 142 patients. Patients CTP class A had significantly lower proportion detectable IL-4 or but higher IL-22 than B/C. IL-6 level well correlated...
Abstract Background We evaluated the long-term effect of stereotactic body radiation therapy (SBRT) for primary small hepatocellular carcinoma (HCC) ineligible local or surgery. Methods Forty-two HCC patients with tumors ≤ 100 cc and ablation surgical resection were treated SBRT: 30-39 Gy a prescription isodose range 70-85% (median 80%) was delivered daily in three fractions. Median tumor volume 15.4 (3.0-81.8) median follow-up duration 28.7 months (8.4-49.1). Results Complete response (CR)...
Reactivation of hepatitis B virus (HBV) during chemotherapy is well documented. However, there are limited data on this complication in patients with hepatocellular carcinoma (HCC) undergoing transarterial chemotherapy. The aim study was to evaluate the efficacy preemptive lamivudine therapy reducing due HBV reactivation HCC chemo-lipiodolization (TACL) and seek predictors event. A total 73 consecutive TACL using epirubicin 50 mg/m2 cisplatin 60 at monthly intervals were prospectively...
The effect of viral suppression on long-term disease outcome after decompensation in patients with hepatitis B virus (HBV)-related cirrhosis has not been established. aim this study was to determine the antiviral therapy (AVT) HBV-related decompensated cirrhosis. This a multicenter, prospective, inception cohort 707 who presented first-onset complications, including 284 untreated and 423 antiviral-treated (58 previously treated, 253 early treatment, 112 delayed treatment). primary endpoint...
Objective The use of tenofovir (TDF) and entecavir (ETV) in patients with chronic hepatitis B (CHB) has led to a decrease the incidence hepatocellular carcinoma (HCC) liver-related events. However, whether there is difference between two agents extent improving such outcomes not been clarified thus far. Therefore, we aimed compare TDF ETV on risk HCC mortality. Design A total 7015 consecutive CHB who were treated or February 2007 January 2018 at liver units Catholic University Korea screened...
The heterogeneity of intermediate-stage hepatocellular carcinoma (HCC) and the widespread use transarterial chemoembolization (TACE) outside recommended guidelines have encouraged development scoring systems that predict patient survival. aim this study was to build validate statistical models offer individualized survival prediction using response TACE as a variable.Clinically relevant baseline parameters were collected for 4,621 patients with HCC treated at 19 centers in 11 countries. In...
Accumulating evidence indicates that components of the systemic inflammatory response, such as C-reactive protein (CRP) and neutrophil-to-lymphocyte ratio (NLR), have been associated with prognosis various cancers. We aimed to elucidate whether CRP NLR could serve potential surrogate markers for response survival in patients hepatocellular carcinoma (HCC).The study population consisted 318 consecutive HCC. were measured at baseline follow-up measurements.With mean 13.9 months, median time...
Background Natural killer (NK) cells can recognize and kill cancer directly, but their activity be attenuated by various inhibitory molecules expressed on the surface. The expression of epithelial cell adhesion molecule (EpCAM), a potential marker for stem (CSCs), is known to strongly associated with poor clinical outcomes in hepatocellular carcinoma (HCC). NK targeting CSCs may promising strategy anti-tumor therapy, little about how they respond EpCAM high HCC. Methods was assessed...
Abstract The treatment decisions for patients with hepatocellular carcinoma are determined by a wide range of factors, and there is significant difference between the recommendations widely used staging systems actual initial choices. Herein, we propose machine learning-based clinical decision support system suitable use in multi-center settings. We collected data from nine institutions South Korea training validation datasets. internal external datasets included 935 1750 patients,...
Background and aims: The underlying molecular mechanisms of hepatocellular carcinoma (HCC) remain poorly understood due to its complex development process. human T cell-specific transcription factor sex-determining region Y-related high-mobility group (HMG) box 4 ( SOX4 ) has been linked tumorigenesis. In this study, we characterized the roles in regulation p53 activity evaluated expression patterns prognostic value HCC. Methods: levels were examined HCC samples obtained from 58 patients...
The role of clinical parameters such as systemic inflammatory response syndrome (SIRS) criteria in predicting the infection remains unclear cirrhosis patients. aim was to evaluate usefulness markers including C-reactive protein (CRP) and neutrophil-to-lymphocyte ratio (NLR) for diagnosis outcomes hospitalized cirrhotic study included 184 patients consecutively from 2011 2012. presence overt survival evaluated. CRP concentration, NLR, Model End-Stage Liver Disease (MELD) score SIRS were...
Abstract Currently, a reliable serum biomarker for hepatocellular carcinoma (HCC) has not been established, particularly early‐stage HCC (single tumor < 2 cm). We aimed to investigate diagnostic exosomal microRNA (exo‐miR) panel HCC. Driver oncogenic miR (onco‐miR) candidates were selected by integrative analysis of expression profiles from three different RNA sequencing datasets human Expressions onco‐miRs in exosome measured using quantitative real‐time PCR. Diagnostic performances...
Liver cirrhosis is one of the major complications hepatitis C virus (HCV) infection, but mechanisms underlying HCV-related fibrogenesis are still not clear. Although roles HCV core protein remain poorly understood, it supposed to play an important role in regulation cellular growth and hepatocarcinogenesis. The aim this study was examine on hepatic fibrogenesis. We established vitro co-culture system with primary stellate cell (HSC) isolated from rats, a stable HepG2-HCV line which had been...
Hepatitis B virus (HBV) is one of the major causative agents chronic liver diseases in Korea. HBV has been classified into 8 genotypes by a divergence >8% entire genomic sequence, and have distinct geographic distributions. There are limited data on relevance between clinical outcomes To investigate feature relating to genotype Korea, total 120 serum samples with HBsAg (65 from Seoul 55 other city Korea) were obtained each 30 carriers asymptomatic carrier (ASC), hepatitis (CH), cirrhosis...
There has been little information about the long-term outcome and prognostic factors in patients with hepatocellular carcinoma (HCC) extrahepatic metastases. The purpose of this study was to investigate clinical affecting survival after metastasis determine benefit controlling intrahepatic HCC.Between 2004 2009, a total 240 consecutive HCC were recruited. Based on tumor extent, performance, hepatic function, underwent locoregional and/or systemic treatments. treatment response other...
Long-term results after downstaging hepatocellular carcinoma (HCC) prior to liver transplantation (LT) remain unknown.To investigate dropouts and post-transplant outcome among patients with downstaged HCC by transarterial chemo-lipiodolization (TACL).Between 2000 2007, 386 initially exceeding Milan criteria underwent TACL for tumour were consecutively enrolled.Overall, 160 (41.5%) achieved successful of within criteria. During the follow-up, 82 eventually dropped off waiting list LT,...
Liver transplantation (LT) is a curative modality for hepatocellular carcinoma (HCC), especially in patients with cirrhosis. However, there are still risks of recurrence. C-reactive protein (CRP), an acute-phase inflammatory reactant that synthesized by hepatocytes, has been related to the prognosis various malignancies, including HCC. In this study, we investigated role high CRP level predicting posttransplant outcomes HCC patients. We analyzed 85 undergoing LT between August 2000 and July...
There are no convincing data supporting the routine use of pre-emptive therapy against HBV reactivation in various loco-regional therapies for hepatocellular carcinoma (HCC). This study investigated incidence, severity and risk factors during therapies.A total 205 prospectively enrolled patients were classified order increasing intensity therapies: local ablation (LAT; 43 patients), transarterial chemotherapy using adriamycin (TAC-ADR; 93 patients) or combined epirubicin-cisplatin (TAC-EC;...