A5078925410- Histone Deacetylase Inhibitors Research
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Cancer-related gene regulation
- Carcinogens and Genotoxicity Assessment
- Gastric Cancer Management and Outcomes
- Cancer-related Molecular Pathways
- Helicobacter pylori-related gastroenterology studies
- Protein Degradation and Inhibitors
- Cancer Mechanisms and Therapy
- Peptidase Inhibition and Analysis
- Gastroesophageal reflux and treatments
- Circular RNAs in diseases
- Sirtuins and Resveratrol in Medicine
- RNA Research and Splicing
- Autophagy in Disease and Therapy
- Effects and risks of endocrine disrupting chemicals
- Advanced Chemical Sensor Technologies
- Ubiquitin and proteasome pathways
- S100 Proteins and Annexins
- Immune Cell Function and Interaction
- Neuroscience and Neuropharmacology Research
- Wnt/β-catenin signaling in development and cancer
- Cancer-related molecular mechanisms research
- Toxic Organic Pollutants Impact
Harvard University
2020-2025
Korea University
2023
Catholic University of Korea
2012-2022
Incheon St. Mary's Hospital
2018-2020
Yang Hospital
2019
Seoul National University
2010-2014
Medizinische Hochschule Hannover
2012
Korea Institute of Science and Technology
2010
Korean Association Of Science and Technology Studies
2010
Dongguk University
2008-2009
Sirtuins are nicotinamide adenine dinucleotide oxidized form (NAD+)-dependent deacetylases and function in cellular metabolism, stress resistance, aging. For sirtuin7 (SIRT7), a role ribosomal gene transcription is proposed, but its cancer has been unclear. In this study we show that SIRT7 expression was up-regulated large cohort of human hepatocellular carcinoma (HCC) patients. knockdown influenced the cell cycle caused significant increase liver cells to remain G1/S phase suppress growth....
The effect of surfactin on the proliferation LoVo cells, a human colon carcinoma cell line, was examined. Surfactin strongly blocked cells by inducing pro-apoptotic activity and arresting cycle, according to several lines evidence DNA fragmentation, Annexin V staining, altered levels poly (ADP-ribose) polymerase, caspase-3, p21(WAF1/Cip1), p53, CDK2 cyclin E. anti-proliferative mediated inhibiting extracellular-related protein kinase phosphoinositide 3-kinase/Akt activation, as assessed...
Abstract Histone deacetylase 2 (HDAC2) is crucial for embryonic development, affects cytokine signaling relevant immune responses, and often significantly overexpressed in solid tumors, but little known of its role human lung cancer. In this study, we demonstrated the aberrant expression HDAC2 cancer tissues investigated oncogenic properties cell lines. inactivation resulted regression tumor growth activation cellular apoptosis via p53 Bax Bcl2 suppression. cycle regulation, caused induction...
// Hyung Seok Kim 1,2,* , Kyo Sun Lee 3,* Hyun Jin Bae 1,2 Jung Woo Eun Qingyu Shen Se Park Chan Shin Hee Doo Yang Mijung Won Sang Yong-Koo Kang 3 and Suk Nam 1,2,4 1 Lab of Oncogenomics, Department Pathology, College Medicine, The Catholic University Korea, Seoul, Republic Korea 2 Functional RNomics Research Center, Orthopedic Surgery, Gyeonggi-do, 4 Cancer Evolution * These authors contributed equally to this work Correspondence to: Nam, email: Keywords : Hepatocellular carcinoma,...
Ubiquitin-binding histone deacetylase 6 (HDAC6) is uniquely endowed with tubulin activity and plays an important role in the clearance of misfolded protein by autophagy. In cancer, HDAC6 has become a target for drug development due to its major contribution oncogenic cell transformation. present study we show that expression was down-regulated large cohort human hepatocellular carcinoma (HCC) patients, low significantly associated poor prognosis HCC patients 5-year overall, disease-free,...
Histone deacetylases (HDACs) are known to play a central role in the regulation of several cellular properties interlinked with development and progression cancer. Recently, HDAC1 has been reported be overexpressed hepatocellular carcinoma (HCC), but its biological roles hepatocarcinogenesis remain elucidated. In this study, we demonstrated overexpression subset human HCCs liver cancer cell lines. inactivation resulted regression tumor growth activation caspase-independent autophagic death,...
Histone deacetylase 2 (HDAC2) is crucial for embryonic development, affects cytokine signaling relevant immune responses and often significantly overexpressed in solid tumors; but little known about its role human hepatocellular carcinoma (HCC). In this study, we showed that targeted-disruption of HDAC2 resulted reduction both tumor cell growth de novo DNA synthesis Hep3B cells. We then demonstrated regulated cycle disruption caused G1/S arrest cycle. transition, selectively induced the...
Triple therapy has been recommended as the most effective treatment for Helicobacter pylori eradication. Despite achieving a comparatively high eradication result, however, around 10% of patients still fail to be cured. Omeprazole can enhance efficacy single and double antibiotic protocols is particularly when combined with clarithromycin nitroimidazole. This study examined effect combining triple omeprazole. A prospective, randomised, unblinded, centre trial was carried out on consecutive...
Aberrant regulation of histone deacetylase 2 (HDAC2) was reported for gastric cancers. However, responsive cancer genes in disease onset and progression are less understood. HDAC2 expression studied by quantitative RT-PCR Western blotting. The functional consequences knockdown on cell-cycle regulation, programmed cell death, gene target identification investigated flow cytometry, blotting, electron microscopy, anchorage-independent colony formation, migration assay whole-genome microarray....
Decreased Natural killer cell activity (NKA) for interferon-gamma production (NKA-IFNγ) has been reported in cancer patients. The aim of this study was to determine the diagnostic performance NKA-IFNγ gastric (GC).NKA-IFNγ levels were decreased 261 GC patients with all stages tumor compared those 48 healthy donors (P < 0.001), and lower associated higher stages. also clinicopathological parameters including size, depth invasion, lymph node metastasis. NKA-INFγ assay had better value (AUC =...
Aberrant regulation of histone deacetylase 2 (HDAC2) contributes to malignant progression in various cancers, but the underlying mechanism leading activation oncogenic HDAC2 remains unknown. In this study, we show that expression is upregulated a large cohort patients with human hepatocellular carcinoma, and high was significantly associated poor prognosis carcinoma. We found mTORC1/NF-κBp50 signaling necessary for growth factor-induced sustained not normal hepatic cells. Growth mTORC1...
Abstract Methylation of histone H3 lysine 4 (H3K4) by Set1/COMPASS occurs co-transcriptionally, and is important for gene regulation. associates with the RNA polymerase II C-terminal domain (CTD) to establish proper levels distribution H3K4 methylations. However, details CTD association remain unclear. Here we report that Set1 N-terminal region COMPASS subunit Swd2, which interact each other, are both needed efficient binding in Saccharomyces cerevisiae . Moreover, a single point mutation...
Abstract The Wnt/β‐catenin signaling pathway regulates various aspects of development and plays important role in human carcinogenesis. Nemo‐like kinase (NLK), which is mediator pathway, phosphorylates T‐cell factor/lymphoid enhancer factor (TCF/LEF) inhibits interaction β‐catenin/TCF complex. Although, NLK known to be a tumor suppressor colon cancer, the other events occurring downstream pathways types cancer remain unclear. In present study, we identified that expression was significantly...
Histone deacetylase 2 (HDAC2) is aberrantly regulated and plays a pivotal role in the development of hepatocellular carcinoma (HCC) through regulation cell-cycle components at transcriptional level, but underlying mechanism leading to oncogenic HDAC2 remains unknown. In this study, we show that expression CK2α (casein kinase II α subunit) was up-regulated large cohort human HCC patients, high significantly associated with poor prognosis patients terms five-year overall survival. It also...
Accurate, rapid, and cost-effective screening tests for hepatitis B virus (HBV) C (HCV) infection may be useful in laboratories that cannot afford automated chemiluminescent immunoassays (CLIAs). We evaluated the diagnostic performance of a novel rapid fluorescent lateral flow immunoassay (LFIA).A LFIA using small bench-top fluorescence reader, Automated Fluorescent Immunoassay System (AFIAS; Boditech Med Inc., Chuncheon, Korea), was developed qualitative detection surface antigen (HBsAg),...