A5085678906- Cardiovascular and exercise physiology
- COVID-19 Clinical Research Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- SARS-CoV-2 and COVID-19 Research
- Body Composition Measurement Techniques
- Long-Term Effects of COVID-19
- Obesity, Physical Activity, Diet
- Physical Activity and Health
- Cardiovascular Effects of Exercise
- Children's Physical and Motor Development
- Heart Rate Variability and Autonomic Control
- Obstructive Sleep Apnea Research
- Respiratory Support and Mechanisms
- Antibiotics Pharmacokinetics and Efficacy
- Injury Epidemiology and Prevention
- Health and Lifestyle Studies
- Cardiovascular Disease and Adiposity
- Music Therapy and Health
- Sports Performance and Training
- Pulmonary Hypertension Research and Treatments
- Obesity and Health Practices
- Asthma and respiratory diseases
- Infectious Encephalopathies and Encephalitis
- COVID-19 Impact on Reproduction
- SARS-CoV-2 detection and testing
The University of Texas Southwestern Medical Center
2016-2024
Parkland Health & Hospital System
2018-2022
Stanford University
2022
Institute for Exercise and Environmental Medicine
2015-2019
Texas Health Dallas
2016-2019
Presbyterian Hospital
2018-2019
Valdosta State University
2016
Texas A&M University – Commerce
2016
Appalachian State University
2016
Ensovibep (MP0420) is a designed ankyrin repeat protein, novel class of engineered proteins, under investigation as treatment SARS-CoV-2 infection.To investigate if ensovibep, in addition to remdesivir and other standard care, improves clinical outcomes among patients hospitalized with COVID-19 compared care alone.Double-blind, randomized, placebo-controlled, trial. (ClinicalTrials.gov: NCT04501978).Multinational, multicenter trial.Adults COVID-19.Intravenous 600 mg, or placebo.Ensovibep was...
Background: Tixagevimab/cilgavimab is a neutralising monoclonal antibody combination hypothesized to improve outcomes for hospitalised COVID-19 patients.Methods: In phase 3, blinded, randomised, placebo-controlled trial, adults at 81 sites on four continents were assigned receive intravenous tixagevimab 300 mg/cilgavimab mg or placebo, in addition remdesivir and other standard care. The primary outcome was time sustained recovery through day 90, defined as 14 consecutive days home after...
Background The ventilatory response to exercise is temporarily augmented in environmentally (e.g., breathing apparatus) or physiologically altered conditions respiratory disease), maintaining constant relative arterial PCO 2 regulation from rest exercise; this augmentation called short‐term modulation (STM) of the exercise. Obesity and/or obstructive sleep apnea could affect and STM capacity due additional mechanical load on system repetitive intermittent hypoxia during sleep. We...
The emergence of the COVID-19 pandemic required an immediate global clinical research response. ACTIV (Accelerating Therapeutic Interventions and Vaccines)-3 trials ACTIV-associated Outpatient Treatment with Anti-Coronavirus Immunoglobulin trial used Good Participatory Practices (GPP) to develop materials for study implementation from a network perspective. GPP guidelines offer framework engaging stakeholders throughout process. This paper provides overview developed their applicability in...
VO2peak is one of the most frequently determined cardiopulmonary exercise test parameters for assessment cardiorespiratory fitness (CRF). However, expressing relative to body weight may underestimate CRF in obese children due large inert fat mass load that they carry. PURPOSE: The purpose this study was examine different methods quantifying 10 and 11 yr old children. METHODS: Ten (11.3 ± 0.6 yr, ht: 149 7 cm, wt: 63 14 kg, BMI percentile 97 1) nine non-obese (10.7 0.4 142 5 36 4 56 19)...
Introduction Dyspnea on exertion (DOE) is a common complaint in otherwise healthy obese women, which may influence and prevent them from engaging physical activity. DOE composed of at least two dimensions: sensory (i.e., intensity) affective emotional response). We examined whether subjective ratings breathlessness (RPB) during exercise were associated with unpleasantness negative emotions, including depression, anxiety, frustration, anger, fear. Methods Otherwise healthy, women underwent...
PURPOSE: Dyspnea on exertion (DOE) is a common symptom in otherwise healthy obese individuals and patients with serious illness. Whether have an exaggerated rating of breathlessness (RPB) as compared nonobese unknown. In retrospective analysis, we investigated RPB who were referred for clinical cardiopulmonary exercise testing (CPET) due to unexplained DOE. METHODS: Data from 112 separated into (BMI < 30; n = 28; 20 F) ≥ 47; 24 groups. All cycled at two individualized constant load work...
PURPOSE: The purpose of this study was to examine dyspnea intensity, descriptors, and associated negative symptoms during exercise in 10 11 year old obese nonobese children. METHODS: 12 (9 boys, age: 11.3 ± 0.6y, height: 149.7 6.7cm, mass: 65.8 14.4kg, BMI percentile: 97.5 1.4, body fat: 46 3%) (5 10.8 0.5y, 143.3 5.2cm, 35.8 3.8kg, 50.3 21.5, 27 6%) underwent 3 constant load tests for 6 minutes each (at 40W, 50% VO2max, VO2max + 20W), a maximal test. Ratings perceived breathlessness (RPB),...
Introduction The purpose of this case series was to investigate the respiratory effects weight loss or gain in obese children over 1 yr. Methods Two filled out physical activity questionnaire for (PAQ‐C) and underwent pulmonary function testing, dual‐energy x‐ray absorptiometry, maximal exercise constant load cycling at 40W before after either yr of: 1) training loss, 2) free‐living gain. were not provided with a supervised intervention Results Subject girl, age 11.8yr, who engaged program...
PURPOSE Not only is fat weight greater in comparisons between nonobese and obese adults but also lean body mass (LBM). In a retrospective analysis, we investigated whether LBM increases with the magnitude of women. We hypothesized that would increase proportion to size. METHODS As part other studies, 207 otherwise healthy women 20 45 yr. had composition determinations by hydrostatic weighing. The subjects were grouped based on their percent (%BF): 1=30≤%BF<40, n=25; 2= 40≤%BF<45, n=54;...
PURPOSE: The effects of adult obesity on lung function at rest, such as reductions in functional residual capacity and expiratory reserve volume, are well recognized. However, the operational volumes while lying supine, during exercise obese children unknown but could create meaningful respiratory limitations. METHODS: 11 nonobese (Ht: 143.3±5.2 cm; Wt: 35.8±3.8 kg; BMI percentile: 50±21; Body fat: 27±6%) 12 149.7±6.7 65.8±14.4 97.5±1.4; 46±3%) underwent dual energy x-ray absorptiometry,...
HISTORY: A 67-year-old former marathon runner with a history of venous thromboembolism was referred for cardiopulmonary exercise testing (CPET) dyspnea on exertion (DOE), drop in fitness, and pre-surgical evaluation pulmonary thromboendarterectomy (PTE). He diagnosed chronic thromboembolic (CTE) disease 3 months prior to referral. His V/Q scan showed multiple perfusion defects. Normal spirometry, lung volumes, diffusion capacity. Right heart catheterization (RHC): RA 5 mm Hg; PA 37/15 Hg...
PURPOSE: Cardiorespiratory fitness (CRF) is used as a diagnostic and prognostic health indicator for all-cause cardiovascular disease mortality (Lee et al, 2010). Thus, properly quantifying interpreting CRF important accurate diagnoses. The current EACPR/AHA Scientific Statement includes peak oxygen uptake (VO2peak) both in ml/min/kg percent of predicted (Guazzi 2016).We have previously shown, small cohort otherwise healthy obese women (n = 26), that adults normal or slightly reduced (~85%...
PURPOSE: Efficiency refers to the amount of work performed for a given energy consumption. Excess body weight is known increase resting oxygen uptake, but not net uptake or mechanical efficiency during non-weight bearing exercise such as cycling in prepubertal children. We examined whether V˙O2/WR slopes incremental were affected by changes composition after 1 year normal and obese 10-12 year-old METHODS: 17 children (9 obese) underwent an test on cycle ergometer dual x-ray absorptiometry at...
INTRODUCTION Breathlessness during exercise, or dyspnea on exertion (DOE), is a common complaint in otherwise healthy obese adults. It possible that the higher perception of breathlessness due to work breathing. Thus, we investigated whether men with high DOE (+DOE) have breathing (i.e., oxygen cost) than low (−DOE). METHODS 27 underwent underwater weighing and 6‐min constant load submaximal cycling exercise at 105 W. They also performed eucapnic voluntary hyperpnea (EVH) determine cost...
PURPOSE: We have previously shown that weight loss improved dyspnea on exertion in obese, otherwise healthy, women. Dyspnea is a multidimensional symptom comprised of at least two distinct domains: sensory-perceptual (i.e., intensity) and affective distress unpleasantness emotional response). Both domains may lead individuals to avoid exercise. In this retrospective study, we investigated the effects obese women men these domains. |METHODS: Twenty-one participants (12 M/9 F, 33 ± 7 yrs, 169...