A5100644691- Cancer-related molecular mechanisms research
- Lung Cancer Treatments and Mutations
- RNA modifications and cancer
- Coronary Interventions and Diagnostics
- Cancer, Hypoxia, and Metabolism
- RNA Research and Splicing
- Genomics and Chromatin Dynamics
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Cancer-related Molecular Pathways
- Cardiac Imaging and Diagnostics
- T-cell and B-cell Immunology
- Autophagy in Disease and Therapy
- FOXO transcription factor regulation
- Acute Myocardial Infarction Research
- Antiplatelet Therapy and Cardiovascular Diseases
- PI3K/AKT/mTOR signaling in cancer
- Advanced Glycation End Products research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Immune Cell Function and Interaction
- Cardiovascular Disease and Adiposity
- Lipoproteins and Cardiovascular Health
- Cancer-related gene regulation
- Poxvirus research and outbreaks
- Heme Oxygenase-1 and Carbon Monoxide
Huazhong University of Science and Technology
2022-2025
Dalian Medical University
2015-2024
Sun Yat-sen University
2018-2023
Capital Medical University
2012-2023
Capital University
2023
Guangdong Ocean University
2023
Qingdao Agricultural University
2022-2023
First Affiliated Hospital of Zhengzhou University
2022-2023
Xinxiang Medical University
2022-2023
Tongren Hospital
2023
Huangkui capsule (HKC), an anti-inflammatory Chinese modern patent medicine, has been now widely applied to the clinical therapy of diabetic nephropathy (DN). However, overall therapeutic mechanisms in vivo are still unclear. Renal tubular epithelial-to-mesenchymal transition (EMT) is one major pathogenesis renal interstitial fibrosis DN. Recently, physiological roles NLRP3 inflammasome activation and toll-like receptor 4 (TLR4)/nuclear factor (NF)-κB signaling closely linked EMT. But, it...
Various studies demonstrate that long noncoding RNAs (IncRNAs) act as oncogenes or tumor suppressors in cancer. However, the function of IncRNAs bladder cancer still remains largely unknown. In this study, we identified an IncRNA, gastric cancer–associated IncRNA1 (GClnc1), which was high abundance tissues and its expression related to poor survival rates patients with vitro vivo assays showed GClnc1 significantly promoted cell proliferation, metastasis, invasiveness Mechanistically, first...
Highlights•YY1 is integrated into the core pluripotency network through BAF complex•YY1 and complex promote ESC proliferation•YY1 activates gene expression to maintain pluripotency•YY1 enriched at ESC-specific super-enhancers expressionSummaryYin Yang 1 (YY1) regulates early embryogenesis adult tissue formation. However, role of YY1 in stem cell regulation remains unclear. has a Polycomb group (PcG) protein-dependent mammalian cells. The PcG-independent functions are also reported, although...
Objectives Adiponectin (APN) secreted from perivascular adipose tissue (PVAT) is one of the important anti-inflammatory adipokines to inhibit development atherosclerosis, but underlying mechanism has not been clarified. In this study, we aimed elucidate how APN regulates plaque formation in atherosclerosis. Methods and Results To assess role by PVAT atherosclerosis progression, performed transplantation experiments on carotid artery model: ApoE knockout (ApoE−/−) mice with a collar placement...
The RNA profiles of tumor-educated platelets (TEPs) possess pathological features that could be used for early cancer detection. However, the utility TEP profiling in detecting colorectal (CRC) versus noncancerous diseases has not yet been investigated. This study assesses diagnostic capacity a cohort patients with CRC and diseases.Transcriptome sequencing isolated from 132 at late stages 190 controls consisting healthy donors ulcerative disease, Crohn's polyps, adenomas was performed...
Ectopic expression of a gibberellin 2-oxidase gene (PcGA2ox1) decreased the content bioactive gibberellins (GAs) in transgenic wheat, producing range dwarf plants with different degrees severity. In at least one case, single transformation event gave rise to T1 dwarfism, phenotypes being stably inherited over four generations. The phenotype, which included dark-green leaves, increased tillering and, severe cases, prostrate growth habit, was replicated by application GA biosynthesis inhibitor...
Abstract Background Little is known about the relationship between N6-methyladenosine (m6A)-related genes and tumor immune microenvironment (TIME) in non-small cell lung cancer (NSCLC). It unclear which m6A regulators are essential for NSCLC progression. The aim of this work was to excavate role m6A-related TIME progression NSCLC. Methods Based on bioinformatics analysis, heterogeneous nuclear ribonucleoprotein C (HNRNPC) considered as most influential regulator. Further study investigated...
Abstract Background Although hepatitis B virus (HBV) infection is a major risk factor for hepatic cancer, the majority of HBV carriers do not develop this lethal disease. Additional molecular alterations are thus implicated in process liver tumorigenesis. Since phosphatase and tensin homolog (PTEN) decreased approximately half cancers, we investigated significance PTEN deficiency HBV-related hepatocarcinogenesis. Methods HBV-positive human cancer tissues were checked expression. Transgenic ,...
Gastric cancer (GC) is one of the most fatal digestive tumors worldwide. Abnormal activation or accumulation nuclear factor-erythroid 2-related factor 2/heme oxygenase 1 (Nrf2/HO-1) axis a malignant event in numerous solid tumors. However, its involvement angiogenesis GC remains unknown. This study investigated role Nrf2/HO-1 GC.The expression Nrf2, HO-1, and vascular endothelial growth (VEGF) BGC-823 cells under hypoxia was analyzed using immunocytochemistry, immunofluorescence, Western...
Obesity is a leading risk factor for development of hepatocellular carcinoma (HCC). High-fat intake produces cytotoxic effects in liver cells, such as excessive reactive oxygen species (ROS) accumulation and apoptosis. How HCC cells regulate ROS level escape the high fat diet (HFD) stress remains unclear. Herein, this work reports critical anti-ROS/apoptotic role ubiquitin-like protein interferon stimulated gene 15 (ISG15) HFD-promoted HCC. In mouse models clinical samples, upregulation...
This study aims to investigate the anti-tumor effect and mechanism of Guiqi Yiyuan Ointment combined with cisplatin on Lewis lung carcinoma-bearing mice via protein kinase RNA-like endoplasmic reticulum kinase(PERK)/eukaryotic translation initiation factor 2α(eIF2α)/activated transcription 4(ATF4)/C/EBP homologous protein(CHOP) signaling pathway. Sixty SPF-grade male C57BL/6 were selected assigned into a blank group modeling by random number table method. After carcinoma, in randomized...
Gliomas are the most common primary brain malignancies and associated with a poor prognosis. Here, we showed that PDZ domain-containing protein membrane-associated guanylate kinase inverted 3 (MAGI3) was downregulated at both mRNA levels in human glioma samples. MAGI3 inhibited proliferation, migration, cell cycle progression of cells its overexpression knockdown studies. By using GST pull-down co-immunoprecipitation assays, found bound to β-catenin through domains PDZ-binding motif...
Heterogeneous nuclear ribonucleoproteins (hnRNPs) are emerging as a crucially important protein family in tumors. However, it is unclear which members essential for cancer progression, and their diverse expression patterns prognostic values rarely reported. In this work, we found that the levels of hnRNPs were all upregulated colon adenocarcinoma (COAD) rectal (READ) tissues. Immunohistochemical staining revealed hnRNPA1, hnRNPA2B1, hnRNPC, hnRNPK, hnRNPR, hnRNPU overexpressed colorectal...
Hepatocellular carcinoma (HCC) is a common malignant cancer with poor prognosis. Cuproptosis and associated lncRNAs are connected progression. However, the information on prognostic value of cuproptosis-related still limited in HCC.We isolated transcriptome clinical HCC from TCGA ICGC databases. Ten genes were obtained related correlated by Pearson's correlation. By performing lasso regression, we created lncRNA model based score (CLS). Comprehensive analyses performed, including fields...
Radiotherapy is an important treatment method for cervical cancer, but the efficacy requires improvement. Therefore, novel methods of are required. Previous data have demonstrated that CXC chemokine ligand 10 (CXCL10) inhibits angiogenesis, induces apoptosis and causes avoidance S phase cell cycle in cancer cells. The aim present study was to evaluate anti‑tumor effect radiotherapy combined with CXCL10 gene therapy. Mouse models carcinoma were created by inoculation HeLa cells, treated...
Androgens and the androgen receptor (AR) are of great importance to spermatogenesis male fertility. AR knockout (ARKO) mice display a complete insensitivity androgens infertility; however, exact molecular mechanism for this effect remains unclear. In study, we found that expression levels Prmt6 mRNA protein were significantly up-regulated in testes ARKO compared wild type (WT) mice. PRMT6 was principally localized nucleus spermatogonia spermatocytes by immunofluorescence staining....