A5022627742- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Mesenchymal stem cell research
- Extracellular vesicles in disease
- Autophagy in Disease and Therapy
- Luminescence and Fluorescent Materials
- Osteoarthritis Treatment and Mechanisms
- MicroRNA in disease regulation
- Organic Light-Emitting Diodes Research
- Immune cells in cancer
- Molecular Sensors and Ion Detection
- RNA Interference and Gene Delivery
- 3D Printing in Biomedical Research
- Peptidase Inhibition and Analysis
- Bone Metabolism and Diseases
- Advanced Battery Materials and Technologies
- Phase Change Materials Research
- Heavy Metal Exposure and Toxicity
- Wound Healing and Treatments
- Adenosine and Purinergic Signaling
- Gas Sensing Nanomaterials and Sensors
- Epigenetics and DNA Methylation
- Drug Transport and Resistance Mechanisms
- Silk-based biomaterials and applications
- Cancer-related molecular mechanisms research
Chongqing University
2024-2025
Air Force Medical University
2015-2025
Huazhong University of Science and Technology
2024-2025
Second Affiliated Hospital of Nanjing Medical University
2022-2025
The University of Melbourne
2023-2025
Zhejiang University of Technology
2023-2025
Shandong Tumor Hospital
2025
Shandong First Medical University
2025
Lanzhou University
2025
Materials Science & Engineering
2024
The demand for the detection of ultralow concentrations ammonia gas is growing. A bimetallic metal–organic framework (MOF) comprising Prussian blue analogs (PBAs) was used to achieve highly sensitive and stable at room temperature in this study. First, PB enriched by using improved sensing properties. Second, a membrane with more vacancies formed partially replacing Fe3+ Cu2+ through cation-exchange strategy. Finally, capacitive sensor developed ultralow-concentration Cu–Fe PBA...
Abstract Macrophages (Mφs) are involved in a variety of physiological and pathological events including wound healing tissue regeneration, which they play both positive negative roles depending on their polarization state. In this study, we investigated the cellular behaviours bone marrow mesenchymal stem cells ( BMMSC s) after incubation different conditioned media CM generated by unpolarized Mφs (M0) or polarized (M1 M2). Mφ was induced stimulation with various cytokines, s were obtained...
Over the past two decades, an accumulating body of evidence indicates that well-designed biomaterials are able to coax homing resident stem cells injured sites and orchestrate their behaviors functions promote tissue regeneration. This paradigm opens a new research avenue, termed endogenous regenerative medicine (ERM) in this manuscript, takes advantage body's own capacity manage broad spectrum ischemic degenerative diseases. By building on hidden potential cells, ERM circumvents complex...
Background Different phenotypes of macrophages (M0, M1 and M2 Mφs) have been demonstrated to play distinct roles in regulating mesenchymal stem cells various vitro vivo systems. Our previous study also found that cell-conditioned medium (CM) derived from Mφs supported the proliferation adipogenic differentiation bone marrow (BMMSCs), whereas CM either M0 or showed an enhanced effect on cell osteogenic differentiation. However, underlying mechanism remains incompletely elucidated. Exosomes,...
Phenylketonuria (PKU) is a common disease in congenital disorder of amino acid metabolism, which can lead to intellectual disability, seizures, behavioral problems, and mental disorders. We report herein facile method screen for PKU by the measurements its metabolites (markers). In this work, disposable electrochemical microsensor modified with ZIF (zeolitic imidazolate framework)-based nanocomposite constructed, ZIF-67 crystals are encapsulated PtPd alloy nanoparticles (NPs) forming...
Mesenchymal stem cells (MSCs) have been widely used in cytotherapy and tissue engineering due to their immunosuppressive ability regenerative potential. Recently, the immunomodulatory influence of MSCs has gaining increasing attention because functional roles modulating immune responses likely high clinical significance. In this study, we investigated on macrophages (Mφs) in-vitro cell culture systems. Given evidence that aged are functionally compromised, bone marrow-derived (BMSCs)...
Abstract Accumulating evidence indicates that the pluripotency of periodontal ligament stem cells (PDLSCs) is compromised under inflammatory conditions; however, underlying mechanisms remain largely unexplored. In this study, we hypothesize P2X7 receptor (P2X7R) a key molecule linked to inflammation-associated impairment PDLSCs. We first investigated P2X7R expression in PDLSCs normal and conditions then determined effect agonist (BzATP) or antagonist (BBG) on PDLSC osteogenesis various...
Although macrophage (Mφ) polarization has been demonstrated to play crucial roles in cellular osteogenesis across the cascade of events periodontal regeneration, how polarized Mφ phenotypes influence cementoblastic differentiation ligament stem cells (PDLSCs) remains unknown. In present study, human monocyte leukemic (THP-1) were induced into M0, M1, and M2 subsets, influences these Mφs on PDLSCs assessed both conditioned medium-based Transwell-based coculture systems. Furthermore, potential...
Although cellular therapy has been proposed for inflammation-related disorders such as periodontitis decades, clinical application unsuccessful. One explanation these disappointing results is that the functions of stem cells are substantially compromised when they transplanted into an inflammatory in vivo milieu. Considering previous finding P2X7 receptor (P2X7R) gene modification able to reverse inflammation-mediated impairment periodontal ligament (PDLSCs), we further hypothesized...
Previously, our investigations demonstrated robust pro-angiogenic potentials of extracellular vesicles secreted by periodontitis-compromised dental pulp stem cells (P-EVs) when compared to those from healthy DPSCs (H-EVs), but the underlying mechanism remains unknown.Here, circulating microRNAs (miRNAs) specifically found in P-EVs (compared with H-EVs) were identified Agilent miRNA microarray analysis, and roles candidate P-EV-enhanced cell angiogenesis confirmed transfection RNA...
Stem cells that have undergone long-term ex vivo expansion are most likely functionally compromised (namely cellular senescence) in terms of their stem cell properties and therapeutic potential. Due to its ability attenuate senescence, melatonin (MLT) has been proposed as an adjuvant protocols, but the mechanism underlying MLT-induced rejuvenation remains largely unknown.Human periodontal ligament (PDLSCs) were isolated cultured for up 15 passages, from passages 2, 7, (P2, P7, P15) used...
Abstract Herein, we present the divergent syntheses of α‐arylacylamides and oxindoles via mechanoredox chemistry by using easily accessible α‐bromo N ‐sulfonyl amides as starting materials. Our system consists a catalytic amount Cu II precatalyst piezoelectric The highly polarized BaTiO 3 or PbTiO under mechanical agitation can act an electron donor to realize recycling I . Control experiments density functional theory calculations have been performed support proposed mechanistic rationale...
Abstract Bile acid metabolites have been increasingly recognized as pleiotropic signaling molecules that regulate cardiovascular functions, but their role in mesenchymal stromal cells (MSC)‐based therapy has never investigated. It is found overexpression of farnesoid X receptor (FXR), a main for bile acids, improves the retention and cardioprotection adipose tissue‐derived MSC (ADSC) administered by intramyocardial injection mice with myocardial infarction (MI), which shows enhanced...
Apple fruit skin color fading is not well understood although the molecular mechanism of formation known. The red-fleshed apple cultivar 'Daihong' (DH) exhibited during development despite having a heterozygous R6 allele but lacking Red-TE for red skin. In this study, transcriptomic analysis revealed expression level