A5053513170- Periodontal Regeneration and Treatments
- Mesenchymal stem cell research
- Oral microbiology and periodontitis research
- Bone Tissue Engineering Materials
- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Oral Health Pathology and Treatment
- Extracellular vesicles in disease
- Photosynthetic Processes and Mechanisms
- Bone Metabolism and Diseases
- dental development and anomalies
- Immune cells in cancer
- Dental Radiography and Imaging
- 3D Printing in Biomedical Research
- Dental Trauma and Treatments
- Graphene and Nanomaterials Applications
- Bone and Dental Protein Studies
- Influenza Virus Research Studies
- Dental Implant Techniques and Outcomes
- Wound Healing and Treatments
- Advanced Drug Delivery Systems
- Pluripotent Stem Cells Research
- Osteoarthritis Treatment and Mechanisms
- Algal biology and biofuel production
- Endodontics and Root Canal Treatments
Air Force Medical University
2016-2025
Stomatology Hospital
2005-2025
Zhejiang University
2020-2025
Northwest Women's and Children's Hospital
2015-2025
Chinese Academy of Sciences
2018-2025
Center for Excellence in Molecular Plant Sciences
2020-2025
University of Chinese Academy of Sciences
2020-2025
China Tobacco
2025
Nanjing University
2015-2024
Guangxi Medical University
2024
Modern sugarcanes are polyploid interspecific hybrids, combining high sugar content from Saccharum officinarum with hardiness, disease resistance and ratooning of spontaneum. Sequencing a haploid S. spontaneum, AP85-441, facilitated the assembly 32 pseudo-chromosomes comprising 8 homologous groups 4 members each, bearing 35,525 genes alleles defined. The reduction basic chromosome number 10 to in spontaneum was caused by fissions 2 ancestral chromosomes followed translocations chromosomes....
Abstract Background Periodontitis, which progressively destroys tooth-supporting structures, is one of the most widespread infectious diseases and leading cause tooth loss in adults. Evidence from preclinical trials small-scale pilot clinical studies indicates that stem cells derived periodontal ligament tissues are a promising therapy for regeneration lost/damaged tissue. This study assessed safety feasibility using autologous (PDLSCs) as an adjuvant to grafting materials guided tissue...
Abstract Background The inflammation and regeneration process may be accompanied by the shift in M1/M2 polarization of macrophages to adapt extracellular signals. How responded altered immunological environment periodontal niche after stem cell transplantation has never been explored. purpose present study is investigate whether participated tissue homeostasis wound healing during ligament (PDLSC)-based regeneration. Methods A rat defect model was utilized observe PDLSC...
Abstract The aim of this study was to identify whether periodontitis induces gut microbiota dysbiosis via invasion by salivary microbes. First, faecal and samples were collected from periodontally healthy participants (PH group, n = 16) patients with severe (SP 21) analysed 16S ribosomal RNA sequencing. Significant differences observed in both the between PH SP groups. Notably, more saliva-sourced microbes group. Then, remaining transplanted into C57BL6/J mice (the C-PH group C-SP group), it...
Exosomes (EXs) shed by mesenchymal stem cells (MSCs) are potent therapeutic agents that promote wound healing and regeneration, but when used alone in vivo, their potency is diminished rapid clearance bioactivity loss. Inspired the biotin-avidin interaction, we developed a simple yet versatile method for immobilization of MSC-derived EXs (MSC-EXs) into hydrogels achieved sustained release regenerative purposes. First, biotin-modified gelatin methacryloyl (Bio-GelMA) was fabricated grafting...
Traumatic brain injury (TBI) is one of the major causes mortality and disability for all ages worldwide. Mesenchymal stem cells (MSCs)-originated exosomes have provided therapeutic effects. However, as an indispensable component MSCs, whether odontogenic cell-generated could benefit TBI still unclear. Thus we aimed to explore potential from human exfoliated deciduous teeth-originated (SHED-Ex) management TBI.First, a transwell system was used co-culture activated BV-2 microglia with SHED....
Although accumulating evidence indicates that macrophages are central players in the destructive and reparative phases of periodontal disease, their polarization states at different stages inflammation remain unclear.We collected gingival biopsies from patients with chronic periodontitis (P group), gingivitis (G or periodontally healthy individuals (H group). Polarized were identified through immunofluorescence. M1- M2-related cytokines detected by immunohistochemistry.Compared H group, P...
Systemic infusion of bone marrow-derived mesenchymal stem cells (BMSCs) has become a promising strategy for disease treatment and tissue regeneration. Strategies to enhance the efficiency BMSC cell therapy are crucial promote its clinical application. Here, we aimed improve by inhibiting BMSC-induced coagulation reaction. Intravenous injection gradient BMSCs into mice showed that were not fully compatible with blood. Large doses induced series symptoms respiratory failure heart failure....
The contradiction between “high yielding” and “early maturing” hampers further improvement of annual rice yield. Here we report the positional cloning a major maturity duration regulatory gene, Early flowering-completely dominant ( Ef-cd ), demonstrate that natural variation in could be used to overcome above contradictory. locus gives rise long noncoding RNA (lncRNA) antisense transcript overlapping OsSOC1 gene. lncRNA expression positively correlates with H3K36me3 deposition. Field test...