A5052447957- Extracellular vesicles in disease
- Oral microbiology and periodontitis research
- Bone Tissue Engineering Materials
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Periodontal Regeneration and Treatments
- Bacterial Infections and Vaccines
- Stress Responses and Cortisol
- Tendon Structure and Treatment
- Dental Implant Techniques and Outcomes
- Mesenchymal stem cell research
- Lipid Membrane Structure and Behavior
- Orthopaedic implants and arthroplasty
- Transplantation: Methods and Outcomes
- Salivary Gland Disorders and Functions
- Wound Healing and Treatments
- Streptococcal Infections and Treatments
- RNA Interference and Gene Delivery
- Cellular Mechanics and Interactions
- Cancer, Hypoxia, and Metabolism
- Autophagy in Disease and Therapy
Air Force Medical University
2022-2024
Exosomes (EXs) shed by mesenchymal stem cells (MSCs) are potent therapeutic agents that promote wound healing and regeneration, but when used alone in vivo, their potency is diminished rapid clearance bioactivity loss. Inspired the biotin-avidin interaction, we developed a simple yet versatile method for immobilization of MSC-derived EXs (MSC-EXs) into hydrogels achieved sustained release regenerative purposes. First, biotin-modified gelatin methacryloyl (Bio-GelMA) was fabricated grafting...
Periodontal ligament stem cells (PDLSCs) are a key cell type for restoring/regenerating lost/damaged periodontal tissues, including alveolar bone, and root cementum, the latter of which is important regaining tooth function. However, PDLSCs residing in an inflammatory environment generally exhibit compromised functions, as demonstrated by impaired ability to differentiate into cementoblasts, responsible regrowing cementum. This study investigated role mitochondrial function downstream long...
Abstract The viscoelasticity of mechanically sensitive tissues such as periodontal ligaments (PDLs) is key in maintaining mechanical homeostasis. Unfortunately, PDLs easily lose (e.g., stress relaxation) during periodontitis or dental trauma, which disrupt cell–extracellular matrix (ECM) interactions and accelerates tissue damage. Here, Pluronic F127 diacrylate (F127DA) hydrogels with PDL‐matched relaxation rates high elastic moduli are developed. hydrogel modulated without chemical...
The positive regulation of bone-forming osteoblast activity and the negative feedback osteoclastic are equally important in strategies to achieve successful alveolar bone regeneration. Here, a molybdenum (Mo)-containing bioactive glass ceramic scaffold with solid-strut-packed structures (Mo-scaffold) was printed, its ability regulate pro-osteogenic anti-osteoclastogenic cellular responses evaluated vitro vivo. We found that extracts derived from Mo-scaffold (Mo-extracts) strongly stimulated...
Periodontitis is the leading cause of tooth loss in adults, and psychological factors play an important role development periodontitis. To elucidate adverse effects stress on inflammatory process redox status periodontitis tissue, fifty male Sprague-Dawley rats were divided into control, experimental periodontitis, stress, plus fluoxetine groups. Chronic unpredictable mild (CUMS) was used to establish silk ligature induce Four weeks later, stressed showed altered behaviour, serum hormone...
Inflammation-induced mitochondrial dysfunction functionally impairs periodontal ligament stem cells (PDLSCs) and hinders their therapeutic efficacy in regeneration. Melatonin, a mitochondrion-targeted molecule, is considered promising anti-inflammatory agent therapeutics, but whether melatonin protects PDLSC cementoblastic differentiation against inflammation-induced damage the underlying mechanisms of this function remain unclear. This study confirmed that rescues under inflammatory...
Objective: To investigate the effects of long non-coding RNA (lncRNA) LINC01133 on cementogenic differentiation human periodontal ligament stem cells (hPDLSC) and underlying mechanism. Methods: A total 12 teeth were harvested from 10 patients aged 17-30 years in Department Oral Maxillofacial Surgery, School Stomatology, The Fourth Military Medical University for impacted or orthodontic reasons September 2021 to January 2022. hPDLSCs isolated transfected with small interfering RNA-LINC01133...