A5101777091- Plant Gene Expression Analysis
- Cancer-related molecular mechanisms research
- Periodontal Regeneration and Treatments
- Plant Molecular Biology Research
- Plant biochemistry and biosynthesis
- Phytochemicals and Antioxidant Activities
- Plant-Microbe Interactions and Immunity
- Wound Healing and Treatments
- Postharvest Quality and Shelf Life Management
- Stroke Rehabilitation and Recovery
- Colorectal Cancer Surgical Treatments
- Dietary Effects on Health
- Mycobacterium research and diagnosis
- Gut microbiota and health
- TGF-β signaling in diseases
- Fermentation and Sensory Analysis
- Stoma care and complications
- Dermatologic Treatments and Research
- Reconstructive Surgery and Microvascular Techniques
- Diet and metabolism studies
- Anorectal Disease Treatments and Outcomes
- Dye analysis and toxicity
- Cytokine Signaling Pathways and Interactions
- Reconstructive Facial Surgery Techniques
- Treatment of Major Depression
Qingdao Agricultural University
2019-2024
First Affiliated Hospital Zhejiang University
2020-2022
Zhejiang University
2014-2022
Beijing Chaoyang Emergency Medical Center
2018
Capital Medical University
2018
Beijing Chao-Yang Hospital
2018
Apple fruit skin color fading is not well understood although the molecular mechanism of formation known. The red-fleshed apple cultivar 'Daihong' (DH) exhibited during development despite having a heterozygous R6 allele but lacking Red-TE for red skin. In this study, transcriptomic analysis revealed expression level
A potential role for microRNA-935 (miR-935) has been identified in several cancers but not non-small cell lung cancer (NSCLC). We hypothesised changes miR-935 NSCLC, and proposed mechanisms that may further explain its carcinogenesis.NSCLC tissue nearby normal was obtained from 101 patients probed by qRT-PCR expression. The of a target (signal transduction factor E2F7) determined lines dual luciferase assay. function investigated through metabolic activity (MTT) transwell migration assays....
In this research, we compared the phenotypical characters, total anthocyanins content, phenols and antioxidant activity of red-fleshed apple cultivars ‘XJ4’, ‘QN-5’, ‘DH’ ‘HX1’ at three fruit developmental stages. A further flavonoids metabolites study was conducted in ‘XJ4’ ‘DH’. We found broader variation content peel four cultivars, which might result larger differences free radicals scavenging rate. The most significant difference phenotype, DPPH rate observed between mature stage....
The mitogen-activated protein kinase (MAPK) signaling cascade is a widely existing signal transduction system in eukaryotes, and plays an important role the processes of plant cells response to environmental stress. In this study, we screened MdMKK9, gene MAPK family. This directly related changes anthocyanin synthesis 'Daihong' variety red-fleshed apple (Malus sieversii f neidzwetzkyana (Dieck) Langenf). MdMKK9 expression was up-regulated tissue culture seedlings cultured at low levels...
Busulfan is currently an indispensable anti-cancer drug, but the side effects on male reproductive system are so serious. Meanwhile, red-fleshed apples natural products with high anthocyanin content. In this research, we analyzed effect of apple extract (RAAE) busulfan-treated mice. Compared busulfan group, main plasma biochemical indicators were significantly improved after RAAE treatment. BA0 (busulfan without RAAE) total antioxidant capacity(T-AOC) and activity superoxide dismutase (SOD)...
Abstract MdCoL, which encodes a putative 2OG-Fe(II) oxygenase, is strong candidate gene for control of the columnar growth phenotype in apple. However, mechanism by MdCoL produces trait unclear. Here, we show that influences abscisic acid (ABA) biosynthesis through its interactions with MdDREB2 transcription factor. Expression analyses and transgenic tobacco studies have confirmed likely phenotype. Furthermore, ABA level apple trees significantly higher than standard trees. A protein...
Background: Long noncoding RNA (lncRNA) LUADT1 is a known oncogenic lncRNA in lung cancer. This study aimed to explore the roles of melanoma. Materials and Methods: Sixty pairs melanoma nontumor tissues were obtained from 60 patients (37 men 23 women, 38–68 years, 52.1 ± 4.9 years) at First Affiliated Hospital Zhejiang University School Medicine. Gene expression was analyzed by quantitative polymerase chain reaction western blot. Cell transfections performed analyze gene expression. Results:...
Although bone marrow-derived mesenchymal stem cells (BMSCs) have attracted increasing attention because of their pivotal functions in the process wound healing and fibrosis alleviation, underlying molecular mechanisms been poorly understood. Moreover, transforming growth factor beta 1 (TGF-β1) is positively correlated with scar formation, whereas TGF-β3 inhibits pathological formation process. However, relation TGF-β1, TGF-β3, TGF-β/Smad signaling pathway BMSCs unknown requires further...
This retrospective study investigated the efficacy and safety of escitalopram oxalate (ESO) for treatment post-stroke depression (PSD). A total 115 patients with PSD were included in this study. 65 underwent ESO (Intervention group). 50 received acupressure (Control The outcome measurements Montgomery-Åsberg Depression Rating Scale (MADRS), Hamilton Anxiety (HAM-A), Sheehan Disability (SDS). In addition, we also recorded adverse events At end 8-week treatment, showed greater depression,...
Red-fleshed apple (Malus sieversii f. neidzwetzkyana (Dieck) Langenf) has attracted more and attention due to its enriched anthocyanins high antioxidant activity. In this study we extracted total phenols from two types of red-fleshed apples-Xinjing No.4 (XJ4) Red Laiyang (RL)-to the stability activity after encapsulation onto Corn Starch Nanoparticles (CSNPs). The results indicated phenol levels XJ4 were 2.96 2.25 times higher than those RL respectively. anthocyanin concentration loading...
Wound scarring remains a major challenge for plastic surgeons. Transforming growth factor (TGF)-β plays key role in the process of scar formation. Previous studies have demonstrated that truncated TGF-β type II receptor (t-TGF-βRII) is unable to continue signal transduction but still capable binding TGF-β, thereby blocking signaling pathway. Hepatocyte (HGF) multifunctional promotes tissue regeneration and wound healing. Theoretically, combination HGF t-TGF-βRII would be expected exert...
Furan is a volatile and carcinogenic heterocyclic chemical compound that occurs in wide range of thermally processed food. It can be induced during food-preparing processes by high temperatures UV-C light. In the present study, degradation furan content ground coffee, Maillard model system, not-from-concentrate (NFC) apple juice red-fleshed anthocyanin extract (RAAE) was studied. The results demonstrated RAAEs had different degrees coffee powder, RAAE from 'XJ3' most significant effect, with...
When a reverse sural neurofasciocutaneous flap is used to reconstruct forefoot defect, usually, the transverse length of increased or pivot point lowered ensure reconstruction range. Therefore, proximal partial necrosis leading surgery failure sometimes caused by insufficient arterial supply if too long low and has no reliable perforator in pedicle. Herein, we describe new method for extending range that can provide higher survival rate.Between July 2010 2014, 24 patients with defect were...