A5073561102- Cardiac Ischemia and Reperfusion
- Mitochondrial Function and Pathology
- Cardiovascular Function and Risk Factors
- Adipose Tissue and Metabolism
- MicroRNA in disease regulation
- Mesenchymal stem cell research
- ATP Synthase and ATPases Research
- Circular RNAs in diseases
- Cardiovascular Disease and Adiposity
- RNA modifications and cancer
- Erythrocyte Function and Pathophysiology
- Extracellular vesicles in disease
- Cardiomyopathy and Myosin Studies
- Galectins and Cancer Biology
- Transplantation: Methods and Outcomes
- Aldose Reductase and Taurine
- Cancer-related molecular mechanisms research
- Connexins and lens biology
- Cardiac Fibrosis and Remodeling
- Lipid metabolism and biosynthesis
- Autophagy in Disease and Therapy
- Mechanical Circulatory Support Devices
- Salivary Gland Disorders and Functions
- GDF15 and Related Biomarkers
- Systemic Sclerosis and Related Diseases
Xijing Hospital
2021-2025
Air Force Medical University
2019-2025
First Affiliated Hospital of Hunan University of Traditional Chinese Medicine
2023
Hegang People's Hospital
2016
Chinese National Human Genome Center
2008
Chinese Academy of Medical Sciences & Peking Union Medical College
2008
Rationale: Long-term exercise provides reliable cardioprotection via mechanisms still incompletely understood. Although traditionally considered a thermogenic tissue, brown adipose tissue (BAT) communicates with remote organs (eg, the heart) through its endocrine function. BAT expands in response to exercise, but involvement remains undefined. Objective: This study investigated whether small extracellular vesicles (sEVs) secreted by and their contained microRNAs (miRNAs) regulate...
Abstract Few intravenously administered mesenchymal stromal cells (MSCs) engraft to the injured myocardium, thereby limiting their therapeutic efficacy for treatment of ischemic heart injury. Here, it is found that irisin pretreatment increases cardiac homing adipose tissue‐derived MSCs (ADSCs) by single and multiple intravenous injections mice with MI/R more than fivefold, which subsequently antiapoptotic, proangiogenic, antifibrotic effects in rats underwent MI/R. RNA sequencing, Kyoto...
Abstract Mesenchymal stem cells (MSCs) delivered into the post-ischemic heart milieu have a low survival and retention rate, thus restricting cardioreparative efficacy of MSC-based therapy. Chronic ischemia results in metabolic reprogramming heart, but little is known about how these changes influence implanted MSCs. Here, we found that excessive branched-chain amino acid (BCAA) accumulation, signature seen was disadvantageous to cardioprotection intramyocardially injected Discovery-driven...
Abstract Mesenchymal stromal cell (MSC) implantation is a promising option for liver repair, but their poor retention in the injured milieu critically blunts therapeutic effects. The aim to clarify mechanisms underlying massive MSC loss post‐implantation and establish corresponding improvement strategies. primarily occurs within initial hours after into or under reactive oxygen species (ROS) stress. Surprisingly, ferroptosis identified as culprit rapid depletion. In ferroptosis‐...
BACKGROUND: Myocardial mitochondrial dysfunction underpins the pathogenesis of heart failure (HF), yet therapeutic options to restore myocardial function are scarce. Epigenetic modifications DNA (mtDNA), such as methylation, play a pivotal role in modulating homeostasis. However, their involvement HF remains unclear. METHODS: Experimental models were established through continuous angiotensin II and phenylephrine (AngII/PE) infusion or prolonged ischemia/reperfusion injury. The landscape N 6...
Abstract Bile acid metabolites have been increasingly recognized as pleiotropic signaling molecules that regulate cardiovascular functions, but their role in mesenchymal stromal cells (MSC)‐based therapy has never investigated. It is found overexpression of farnesoid X receptor (FXR), a main for bile acids, improves the retention and cardioprotection adipose tissue‐derived MSC (ADSC) administered by intramyocardial injection mice with myocardial infarction (MI), which shows enhanced...
BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) has become the most prevalent type of heart failure, but effective treatments are lacking. Cardiac lymphatics play a crucial role in maintaining health by draining fluids and immune cells. However, their involvement HFpEF remains largely unexplored. METHODS: We examined cardiac lymphatic alterations mice comorbid obesity hypertension, tissues from patients HFpEF. Using genetically engineered mouse models various cellular...
Abstract Nectin‐like molecule 1 (NECL1)/CADM3/IGSF4B/TSLL1/SynCAM3 is a neural tissue‐specific immunoglobulin‐like cell–cell adhesion downregulated at the mRNA level in 12 human glioma cell lines. Here we found that expression of NECL1 was lost six lines and 15 primary tissues both RNA protein levels. Re‐expression into line U251 would repress proliferation vitro by inducing cycle arrest. And also could decrease growth rate tumors nude mice vivo . To further investigate mechanism why...
Rationale: The transformation of fibroblasts into activated myofibroblasts is a critical step that results in cardiac fibrosis upon myocardial infarction (MI). Leucine-rich repeat-containing protein-8A (LRRC8A) multi-functional protein involved cell survival, growth, and proliferation, whereas its role regulating myofibroblast phenotypes remains unknown. Methods: Conditional myofibroblast-specific Lrrc8a knockout mouse models were established by crossing the Lrrc8aflox/flox mice with...
Abstract Aims βII spectrin is a cytoskeletal protein known to be tightly linked heart development and cardiovascular electrophysiology. However, the roles of in cardiac contractile function pathological post-myocardial infarction remodelling remain unclear. Here, we investigated whether how spectrin, most common isoform non-erythrocytic cardiomyocytes, involved ischaemia/reperfusion (I/R) injury. Methods results We observed that levels serum breakdown products (βII SBDPs) were significantly...
Background Hypertrophic cardiomyopathy (HCM) is a widely distributed, but clinically heterogeneous genetic heart disease, affects approximately 20 million people worldwide. Nowadays, HCM treatable with the advancement of medical interventions. However, due to occult clinical presentations and lack easy, inexpensive, popularized screening approaches in general population, 80–90% patients are not identifiable, which brings certain safety hazards could have been prevented. The majority showed...
Abstract Background: Hypertrophic cardiomyopathy (HCM) is an underdiagnosed genetic heart disease worldwide. The management and prognosis of obstructive HCM (HOCM) non-obstructive (HNCM) are quite different, but it also remains challenging to discriminate these two subtypes. characterized by dysmetabolism, myocardial amino acid (AA) metabolism robustly changed. present study aimed delineate plasma AA derivatives profiles, identify potential biomarkers for HCM. Methods: Plasma samples from...
Cardiac energy homeostasis is strictly controlled by the mitochondrial complex-mediated respiration. In heart, complex I highly susceptible to functional and structural destroy after ischemia/reperfusion (I/R), thereby contributing myocardial insufficiency cardiomyocyte death. Fas-activated serine/threonine kinase (FASTK) recently recognized as a key modulator of gene expression However, role FASTK in cardiac I/R process undetermined. Here, we show that was down-regulated post-I/R heart. The...
Mesenchymal Stromal Cells In article number 2200431, Wenjun Yan, Ling Tao, and co-workers report a novel strategy for improving the curative effect of mesenchymal stromal cell (MSC)-based therapy myocardial infarction that is achieved by bile acid- arnesoid X receptor (FXR) axis activation. FXR overexpression in MSC facilitates response to endogenous acid signals, thus enhancing survival paracrine angiogenesis MSC.
Mesenchymal Stromal Cell (MSC) Ferroptosis As reported in article number 2206439 by Ling Tao, Fuyang Zhang, and co-workers, MSCs are seriously damaged the reactive oxygen species (ROS) after injection into injured liver milieu rapidly deplete due to ferroptosis driven ROS-induced lipid peroxidation, like devouring fire forest threatening entered firefighters. Strategies reducing ferroptosis, such as incorporating inhibitors or overexpressing BCAT1, protect implanted from ROS-irritated hence...
Abstract βII spectrin is a cytoskeletal protein known to be tightly linked heart development and cardiovascular electrophysiology. However, roles of in cardiac contractile function post-myocardial infarction pathological remodeling remain unclear. Here, we uncovered that the levels serum breakdown products (βII SBDPs) were significantly increased patients with acute myocardial infarction. Consistently, was degraded into SBDPs by calpain mouse hearts after ischemia/reperfusion (I/R) injury....