Tongzheng Li

ORCID: 0000-0002-7067-1358
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Research Areas
  • Ferroptosis and cancer prognosis
  • Advanced Sensor and Energy Harvesting Materials
  • Autophagy in Disease and Therapy
  • ZnO doping and properties
  • Thin-Film Transistor Technologies
  • Transition Metal Oxide Nanomaterials
  • Epigenetics and DNA Methylation
  • Cancer-related molecular mechanisms research
  • Machine Learning in Bioinformatics
  • Peroxisome Proliferator-Activated Receptors
  • Mitochondrial Function and Pathology
  • Conducting polymers and applications
  • RFID technology advancements
  • Ga2O3 and related materials
  • Circular RNAs in diseases
  • Extracellular vesicles in disease
  • Antenna Design and Analysis
  • Advanced Antenna and Metasurface Technologies
  • MicroRNA in disease regulation
  • RNA modifications and cancer

Xijing Hospital
2023-2025

Air Force Medical University
2023-2025

Qingdao University
2019-2023

Abstract Mesenchymal stromal cell (MSC) implantation is a promising option for liver repair, but their poor retention in the injured milieu critically blunts therapeutic effects. The aim to clarify mechanisms underlying massive MSC loss post‐implantation and establish corresponding improvement strategies. primarily occurs within initial hours after into or under reactive oxygen species (ROS) stress. Surprisingly, ferroptosis identified as culprit rapid depletion. In ferroptosis‐...

10.1002/advs.202206439 article EN cc-by Advanced Science 2023-02-19

BACKGROUND: Myocardial mitochondrial dysfunction underpins the pathogenesis of heart failure (HF), yet therapeutic options to restore myocardial function are scarce. Epigenetic modifications DNA (mtDNA), such as methylation, play a pivotal role in modulating homeostasis. However, their involvement HF remains unclear. METHODS: Experimental models were established through continuous angiotensin II and phenylephrine (AngII/PE) infusion or prolonged ischemia/reperfusion injury. The landscape N 6...

10.1161/circulationaha.123.068358 article EN mit Circulation 2024-04-30

BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) has become the most prevalent type of heart failure, but effective treatments are lacking. Cardiac lymphatics play a crucial role in maintaining health by draining fluids and immune cells. However, their involvement HFpEF remains largely unexplored. METHODS: We examined cardiac lymphatic alterations mice comorbid obesity hypertension, tissues from patients HFpEF. Using genetically engineered mouse models various cellular...

10.1161/circulationaha.124.071741 article EN Circulation 2025-04-01

Introduction Autophagy refers to the process of breaking down and recycling damaged or unnecessary components within a cell maintain cellular homeostasis. Heart failure (HF) is severe medical condition that poses serious threat patient's life. known play pivotal role in pathogenesis HF. However, our understanding specific mechanisms involved remains incomplete. Here, we identify autophagy-related genes (ARGs) associated with HF, which believe will contribute further comprehending Methods By...

10.3389/fcvm.2024.1247079 article EN cc-by Frontiers in Cardiovascular Medicine 2024-01-29

In this article, we demonstrate a high-performance thin film transistor (TFT) based on double-stack fluorine-doped In2O3/In2O3(InFO/InO) homojunction channel. The InFO and In2O3 semiconductor films were fabricated by solution process acted as front back channels, respectively. By using the unique bandgap characteristic of fluorine dopant, TFT InFO/InO channel exhibits improved electrical performance, including field-effect mobility ( <inline-formula...

10.1109/ted.2023.3268042 article EN IEEE Transactions on Electron Devices 2023-05-01

α-Synuclein (α-Syn) is a major biomarker of Parkinson's disease (PD). Concentration detection α-Syn in cerebrospinal fluid and plasma patients are used as clue for early PD detection. Herein, we propose thin-film transistor (TFT) biosensor based on an indium gallium zinc oxide (IGZO) thin film fabricated by the sol-gel method. The IGZO TFT after surface functionalization α-Syn. worked extended gate tin sensing platform instead channel layer TFT. Depending concentrations human plasma, diluted...

10.1063/5.0151300 article EN Applied Physics Letters 2023-06-12

In this work, In2O3 nanofibers were fabricated by electrospinning, and a field effect transistor (FET) based on was integrated. A hydroxyl-assisted strategy proposed for both stability performance enhancement the FET. Hydrogen peroxide (H2O2) added into precursor solution electrospinning. It is found that of FET improved after H2O2 incorporation, while mobility decreased. Surprisingly, UV irradiation, with high obtained. assumed under decomposed highly reactive hydroxyl radicals (•OH), which...

10.1063/5.0128457 article EN Applied Physics Letters 2022-12-26

Mesenchymal Stromal Cell (MSC) Ferroptosis As reported in article number 2206439 by Ling Tao, Fuyang Zhang, and co-workers, MSCs are seriously damaged the reactive oxygen species (ROS) after injection into injured liver milieu rapidly deplete due to ferroptosis driven ROS-induced lipid peroxidation, like devouring fire forest threatening entered firefighters. Strategies reducing ferroptosis, such as incorporating inhibitors or overexpressing BCAT1, protect implanted from ROS-irritated hence...

10.1002/advs.202370081 article EN cc-by-nc Advanced Science 2023-05-01

Abstract Background Autophagy refers to the process of breaking down and recycling damaged or unnecessary components within a cell maintain cellular homeostasis. Heart failure (HF) is severe medical condition that poses serious threat patient's life. known play pivotal role in pathogenesis HF. However, our understanding specific mechanisms involved remains incomplete. Here, we identify autophagy-related genes (ARGs) associated with HF, which believe will contribute further comprehending...

10.21203/rs.3.rs-3582326/v1 preprint EN cc-by Research Square (Research Square) 2023-11-20

In this paper, a wideband flexible antenna using paper as substrate is proposed. The simulated bandwidth covers 270-1000 MHz. Simulation shows that the proposed has stable with changing dielectric constant and thickness of substrate. keeps table when twisted around cylindra. bandwith

10.1109/iwem.2019.8887930 article EN 2019-09-01
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