A5100682213- Psoriasis: Treatment and Pathogenesis
- Liver Disease Diagnosis and Treatment
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Cytokine Signaling Pathways and Interactions
- Hepatitis C virus research
- Adipose Tissue and Metabolism
- Hepatitis B Virus Studies
- melanin and skin pigmentation
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Acute Myeloid Leukemia Research
- Autophagy in Disease and Therapy
- Autoimmune Bullous Skin Diseases
- Urticaria and Related Conditions
- Electrical and Bioimpedance Tomography
- Cancer Mechanisms and Therapy
- interferon and immune responses
- Immune Cell Function and Interaction
- Skin and Cellular Biology Research
- Inflammasome and immune disorders
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Immune Response and Inflammation
- Traditional Chinese Medicine Analysis
- Pancreatic function and diabetes
- Adipokines, Inflammation, and Metabolic Diseases
Air Force Medical University
2015-2025
Xijing Hospital
2015-2025
Institute of Hematology & Blood Diseases Hospital
2015-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Shenzhen University Health Science Center
2024
Tsinghua University
2024
Second Affiliated Hospital of Jilin University
2021-2024
Xuzhou Medical College
2024
Second People’s Hospital of Huai’an
2024
China Medical University
2016-2024
With advances in the effectiveness of treatment and disease management, contribution chronic comorbid diseases (comorbidities) found within Charlson comorbidity index to mortality is likely have changed since development 1984. The authors reevaluated reassigned weights each condition by identifying following patients observe 1 year after hospital discharge. They applied updated discharge data from 6 countries tested for their ability predict in-hospital mortality. Compared with original...
Epidermal infiltration of neutrophils is a hallmark psoriasis, where their activation leads to release neutrophil extracellular traps (NETs). The contribution NETs psoriasis pathogenesis has been unclear, but here we demonstrate that drive inflammatory responses in skin through epidermal TLR4/IL-36R crosstalk. This dependent upon formation and integrity, as targeting with DNase I or CI-amidine vivo improves disease the imiquimod (IMQ)-induced psoriasis-like mouse model, decreasing IL-17A,...
Either insufficient or excessive autophagy causes cellular death and contributes to myocardial ischaemia/reperfusion (I/R) injury. However, mechanisms controlling the 'right-level' of in heart remains unidentified. Thioredoxin-interacting protein (TXNIP) is a pro-oxidative molecule knowing contribute I/R whether how TXNIP may further inhibit suppressed promote cardiac has not been previously investigated.Wild type gene-manipulated adult male mice were subjected I/R. was increased myocardium...
Neutrophils have a pathogenic function in inflammation via releasing pro-inflammatory mediators or neutrophil extracellular traps (NETs). However, their heterogeneity and mechanisms remain unclear. Here, we demonstrate that CXCR4hi neutrophils accumulate the blood inflamed skin human psoriasis, correlate with disease severity. Compared to CXCR4lo neutrophils, enhanced NETs formation, phagocytic function, degranulation, overexpression of cytokines chemokines vitro. This is accompanied by...
-Vascular actions of progesterone have been reported, independently estrogen, affecting both blood pressure and other aspects the cardiovascular system. To study possible mechanisms underlying these effects, we examined effects P in vivo intact rats vitro isolated artery vascular smooth muscle cell preparations. In anesthetized Sprague-Dawley rats, bolus intravenous injections (100 µg/kg) significantly decreased pressor responses to norepinephrine (0.3 µg/kg). vitro, (10(-8) 10(-5) mmol/L)...
Generalized pustular psoriasis (GPP) is a rare and severe inflammatory skin disease that can be life-threatening. Gene mutations are found in some cases, but its immune pathogenesis largely unknown. Here, we observed the neutrophil:lymphocyte ratio patients with GPP was higher than healthy controls decreased after effective treatment. Neutrophils isolated from induced expressions of genes including IL-1β, IL-36G, IL-18, TNF-α, C-X-C motif chemokine ligands keratinocytes normal neutrophils...
To understand the molecular mechanism of tumorigenesis pulmonary lymphoepithelioma-like carcinoma and explore potential therapeutic strategies, we investigated genomic profiles PD-L1 expression 29 Chinese patients at various stages. We performed capture-based targeted sequencing on tissue samples collected from 27 with sufficient using a panel consisting 520 cancer-related genes, spanning 1.64 Mb human genome. identified 184 somatic mutations in 109 genes 26 patients. One patient had no...
Objective Variations of conductive fluid content in brain tissue (e.g. cerebral edema) change impedance and can potentially be measured by Electrical Impedance Tomography (EIT), an emerging medical imaging technique. The objective this work is to establish the feasibility using EIT as tool for monitoring content. Design a prospective study. Setting In study was used, first time, monitor variations clinical model with patients undergoing dehydration treatment. system developed house its...
Cerebral edema after brain injury can lead to damage and death if diagnosis treatment are delayed. This study investigates the feasibility of employing electrical impedance tomography (EIT) as a non-invasive imaging tool for monitoring development cerebral edema, in which related water content is compared with intracranial pressure (ICP). We enrolled forty patients hemorrhage who underwent lateral external ventricular drain intraventricular ICP EIT 3 h initiation dehydration treatment. The...
To investigate the effect of stimulation human bronchial epithelial cells (HBECs) by arterial traffic ambient PM2.5 (TAPM2.5) and wood smoke (WSPM2.5) on expression long non-coding RNAs (lncRNAs) in order to find new therapeutic targets for treatment chronic obstructive pulmonary disease (COPD). HBECs were exposed TAPM2.5 WSPM2.5 at a series concentrations. The microarray analysis was used detect lncRNA mRNA profiles. Kyoto Encyclopedia Genes Genomes (KEGG) pathway gene ontology (GO)...
Abstract Background Mesenchymal stem cells (MSCs) have a therapeutic effect on diabetic nephropathy (DN) but the underlying mechanism remains unclear. This study was conducted to investigate whether human umbilical cord-MSCs (hUCMSCs) can induce oxidative damage and apoptosis by activating Nrf2. Methods We used type 2 rat model high-glucose fat-stimulated glomerular mesangial cell (hGMC) model. Western blotting, RT-qPCR, TUNEL staining were performed animal tissues cultured cells. Nuclear...
Summary Purpose: Epilepsy imposes a significant burden on society. The objective of this study was to estimate health resource utilization (HRU) over 1‐year period in epilepsy patients, using administrative databases. Methods: Three databases (inpatient, emergency, and physician claims) were used identify cases. HRU variables included general (GP) emergency (ER) visits, billings, hospitalizations, length stay (LOS). Logistic regression determine the association between demographic...
Tumor necrosis factor-α (TNF-α) antagonism alleviates myocardial ischemia-reperfusion (MI/R) injury. However, the mechanisms by which downstream mediators of TNF-α change after acute during MI/R remain unclear. Adiponectin (APN) exerts anti-ischemic effects, but it is downregulated MI/R. This study was conducted to investigate whether responsible for decrease APN, and antagonizing affects injury increasing APN. Male adult wild-type (WT), APN knockout (APN KO) mice, those with cardiac...
Psoriasis is an autoimmune skin disease, in which keratinocytes play a crucial pathogenic role. High-mobility group protein B1 (HMGB1) inflammatory factor that can be released from keratinocyte nuclei psoriatic lesions. We aimed to investigate the proinflammatory effect of HMGB1 on and contribution psoriasis development. Normal human were treated with recombinant HMGB1, production factors intermediary signalling pathways examined. Furthermore, imiquimod-induced psoriasis-like mouse model was...
Abstract Psoriasis is a common chronic inflammatory skin disease characterized by epidermal hyperplasia and dermal inflammation. Keratinocyte activation known to play critical role in psoriasis, but the underlying mechanism remains unclear. Interferon-inducible protein 16 (IFI16), an innate immune system sensor, reported affect keratinocyte function. We therefore hypothesized that IFI16 promotes psoriasis modulating activation. In present study, we cinfirmed was overexpressed keratinocytes...