A5008115520- Neuroscience and Neuropharmacology Research
- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Memory and Neural Mechanisms
- Computational Drug Discovery Methods
- Autophagy in Disease and Therapy
- Parkinson's Disease Mechanisms and Treatments
- RNA regulation and disease
- Retinal Development and Disorders
- Receptor Mechanisms and Signaling
- Neurogenesis and neuroplasticity mechanisms
- Cellular transport and secretion
- Phytochemicals and Medicinal Plants
- Medicinal Plants and Neuroprotection
- MicroRNA in disease regulation
- Phosphodiesterase function and regulation
- Ginger and Zingiberaceae research
- Kruppel-like factors research
- Signaling Pathways in Disease
- 14-3-3 protein interactions
- Tryptophan and brain disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- RNA Research and Splicing
- TGF-β signaling in diseases
- Lung Cancer Treatments and Mutations
Huazhong University of Science and Technology
2017-2025
Air Force Medical University
2017-2023
Ministry of Education of the People's Republic of China
2022
Discovery Institute
2018-2020
Sanford Burnham Prebys Medical Discovery Institute
2018-2020
Xijing Hospital
2017-2019
Central South University
2011-2017
Mutations in <i>PINK1</i> (PTEN-induced putative kinase 1) cause early onset familial Parkinson's disease (PD). PINK1 accumulates on the outer membrane of damaged mitochondria followed by recruiting parkin to promote mitophagy. Here, we demonstrate that BCL2/adenovirus E1B 19-kDa interacting protein 3 (BNIP3), a mitochondrial BH3-only protein, interacts with accumulation full-length mitochondria, which facilitates recruitment and PINK1/parkin-mediated Inactivation BNIP3 mammalian cells...
Epidermal infiltration of neutrophils is a hallmark psoriasis, where their activation leads to release neutrophil extracellular traps (NETs). The contribution NETs psoriasis pathogenesis has been unclear, but here we demonstrate that drive inflammatory responses in skin through epidermal TLR4/IL-36R crosstalk. This dependent upon formation and integrity, as targeting with DNase I or CI-amidine vivo improves disease the imiquimod (IMQ)-induced psoriasis-like mouse model, decreasing IL-17A,...
Dynamic change of mitochondrial morphology and distribution along neuronal branches are essential for neural circuitry formation synaptic efficacy. However, the underlying mechanism remains elusive. We show here that Pink1 knockout (KO) mice display defective dendritic spine maturation, reduced axonal vesicles, abnormal connection, attenuated long-term potentiation (LTP). Drp1 activation via S616 phosphorylation rescues deficits maturation in KO neurons. Notably, harboring a knockin (KI)...
Accumulating evidence suggests that gut microbiota as a critical mediator of gut-brain axis plays an important role in human health. Altered microbial profiles have been implicated increasing the vulnerability psychiatric disorders, such autism, depression, and schizophrenia. However, cellular molecular mechanisms underlying association remain unknown. Here, we modified microbiome with antibiotics newborn mice, found alteration induced behavioral impairment by decreasing adult neurogenesis...
Highlights•Molecularly defined and functionally distinct D28K+ D28K− subnetworks•D28K+ subnetworks differ in morphological physiological properties•D28K+ → VPNs cholinergic subnetwork controls anxiety-like behaviors via Kcnh1•D28K− DGNs encodes spatial memory Cacna1hSummaryCholinergic neurons the medial septum (MS) constitute a major source of input to forebrain modulate diverse functions, including sensory processing, memory, attention. Most studies date have treated as single population;...
Evidence continues to accumulate that pesticides are the leading candidates of environmental toxins may contribute pathogenesis Parkinson’s disease. The mechanisms, however, remain largely unclear. According epidemiological studies, we selected nine representative (paraquat, rotenone, chlorpyrifos, pendimethalin, endosulfan, fenpyroximate, tebufenpyrad, trichlorphon and carbaryl) which commonly used in China detected effects on mitochondria ubiquitin-proteasome system (UPS) function. Our...
Tourette’s syndrome (TS) is a major neurodevelopmental disorder characterized by childhood-onset motor and vocal tics. A W88C mutation in WWC1 gene notable risk factor for TS, but the underlying molecular mechanisms remain unclear due to lack of suitable animal models. Here, we generate mutant mouse line with human (W88C Mut mice), which exhibits behavioral deficits similar those observed patients including repetitive behaviors sensorimotor gating abnormalities. The leads degradation kidney...
Mossy cells (MCs) are a unique group of excitatory neurons in the hippocampus, brain region important for emotion, learning, and memory. Due to lack reliable method isolate MCs from other cell types, how integrate neural information convey it their synaptic targets engaging specific function still unknown. Here, we report that control efficacy spatial memory retrieval by synapsing directly onto local somatostatin-expressing (SST) cells. MC-SST transmission undergoes long-term potentiation...
Abstract Recently, we have reported that dentate mossy cells (MCs) control memory precision via directly and functionally innervating local somatostatin (SST) inhibitory interneurons. Here, report a discovery dysfunction of synaptic transmission between MCs SST causes imprecision in mouse model early Alzheimer's disease (AD). Single‐cell RNA sequencing reveals miR‐128 binds to 3′UTR STIM2 inhibits translation is increasingly expressed from AD mice. Silencing or disrupting binding evokes...
Stroke activates microglia pro-inflammatory response that not only induces the early neuronal injuries but also causes secondary brain infarction. Yet, underlying mechanisms for how become activated in stroke are still unknown. Here, using next-generation of RNA sequencing we find a total 778 genes increasingly expressed mice. Of these, identified Hmgb2 as mediator by promoting transcription Ctss. Inhibition either or Ctss blocks and protects against damages improves neurological functions...
SORLA is a transmembrane trafficking protein associated with Alzheimer's disease risk. Although abundantly expressed in neurons, physiological roles for remain unclear. Here, we show that cultured transgenic neurons overexpressing feature longer neurites, and accelerated neurite regeneration wounding. Enhanced release of soluble form (sSORLA) observed mouse human SORLA, while purified sSORLA promotes extension regeneration. Phosphoproteomic analyses demonstrate enrichment phosphoproteins...
The hippocampus is a temporal lobe structure critical for cognition, such as learning, memory, and attention, well emotional responses. Hippocampal dysfunction can lead to persistent anxiety and/or depression. However, how millions of neurons in the are molecularly structurally organized engage their divergent functions remains unknown. Here, we genetically target subset expressing coagulation factor c homolog (COCH) gene. COCH-expressing or COCH topographically segregated distal region...
Abstract Background Aldh1a1 neurons are a subtype of gamma-aminobutyric acid (GABA) inhibitory that use rather than glutamate decarboxylase (GAD) as an enzyme for synthesizing GABA transmitters. However, the behaviors and circuits this newly identified interneurons remain unknown. Methods We generated mutant mouse line in which cyclization recombination (CRE) was expressed under control promotor (Aldh1a1-CRE mice). Using strain mice together with heterozygous male Alzheimer’s disease (AD)...
The third isoform of the Na+-Ca2+ exchanger (NCX3) is crucial for a physiological fine-tuning Ca2+ fluxes in excitable tissues. In this view, NCX3 accounts aberrant influx seen during neuronal excitotoxicity, such as Alzheimer's disease (AD). However, little known about regulation and functional properties. Withania somnifera (L.) Dunal (W. somnifera), traditional indigenous plant widely recognized having numerous medicinal values, was undertaken to determine its potential therapeutic...