A5062685009- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Oral Health Pathology and Treatment
- Cancer Cells and Metastasis
- Autoimmune Bullous Skin Diseases
- Toxin Mechanisms and Immunotoxins
- Genetic factors in colorectal cancer
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Ferroptosis and cancer prognosis
- Psoriasis: Treatment and Pathogenesis
- Cancer Research and Treatments
- Epigenetics and DNA Methylation
- Immune cells in cancer
- TGF-β signaling in diseases
- Prostate Cancer Treatment and Research
- RNA and protein synthesis mechanisms
- Urticaria and Related Conditions
- Phytochemical Studies and Bioactivities
- Cancer Mechanisms and Therapy
- Click Chemistry and Applications
- Skin and Cellular Biology Research
- Heat shock proteins research
- Immune Response and Inflammation
- Dermatology and Skin Diseases
University of Minnesota Medical Center
2025
Masonic Cancer Center
2025
Guangdong Ocean University
2024
University of California, Davis
2023-2024
University of Colorado Anschutz Medical Campus
2019-2023
University of California Davis Medical Center
2023
State Key Laboratory of Oral Diseases
2023
Sichuan University
2023
Guangxi Medical University
2021
Air Force Medical University
2016-2020
Psoriasis is characterized by keratinocyte hyperproliferation. While significant progress has been made in understanding the molecular mechanism regulating proliferation of keratinocytes, little known about epigenetic factors that control this process. EZH2 and mediated trimethylation histone H3 lysine 27 (H3K27me3) was previously shown ectopically expressed carcinoma proliferation, thereby we sought to clarify role EZH2-H3K27me3 psoriatic keratinocyte. Interestingly, found H3K27me3 were...
Abstract Non-lymphoid immunoregulatory cells, including mesenchymal stem cells (MSCs), myeloid-derived suppressor (MDSCs), regulatory macrophages (Mregs), and tolerogenic dendritic (Tol-DCs), play critical roles in maintaining immune homeostasis. However, their therapeutic application autoimmune diseases graft-versus-host disease (GVHD) has received comparatively less attention. Induced pluripotent (iPSCs) offer a promising platform for cell engineering, enabling superior quality control,...
We show protein kinase C-zeta (PKC-ζ) to be a novel predictive biomarker for survival from prostate cancer (P < 0.001). also confirm that transcription of the PRKC-ζ gene is crucial malignant phenotype human cancer. Following siRNA silencing in PC3-M cells, stable transfectant cell line si-PRKC-ζ-PC3-M(T1-6) phenotypically nonmalignant vitro and vivo. Genome-wide expression analysis identified 373 genes differentially expressed knockdown cells 4 key networks significantly perturbed during...
While immune checkpoint inhibitors (ICI) were approved for head and neck squamous cell carcinomas (HNSCCs), the response rate remains relatively low. Mechanisms underlying ICI unresponsiveness versus sensitivity are not fully understood.
Background Oral squamous cell carcinoma (OSCC) is a devastating disease most often associated with tobacco consumption that induces field of mutations from which tumor arises. Identification ways to prevent the emergence cancer in high-risk patients an ultimate goal for combatting all types cancer, including OSCC. Methods Our study employs mouse model tongue carcinogenesis induced by carcinogen mimetic, 4-nitroquinoline 1-oxide (4NQO), establish dysplasia and We use conventional histology,...
Previously, using gene-knockdown techniques together with genome expression array analysis, we showed the gene protein Kinase C (PKC)-zeta (PRKCZ) to mediate malignant phenotype of human prostate cancer. However, according NCBI, has undergone several major iterations. Therefore, understand relationship between its structure and biological activities, have analysed expressed sequence in cancer cell lines tissues. Transcriptome-walking targeted PCR were used mRNA transcribed from PRKCZ....
Peutz‑Jeghers syndrome (PJS) is a hereditary disorder characterized by mucocutaneous pigmentations, gastrointestinal (GI) polyposis and an increased risk of certain malignancies. Little known about the causative genes PJS, or their association with clinical phenotypes PJS. The present study reports results genetic analysis three Chinese families In addition, medical histories manifestations these were compared. DNA was collected from blood samples patients PJS controls. Serine/threonine...
Life is controlled by the timely and ordered expression of genes. Identification important genes involved in specific physiological pathological conditions requires efficient methods to analyse differential gene expression. We describe a novel strategy, namely complete comparison (CCGE), for systematic assessment differentially expressed Using CCGE method, double-stranded cDNA digested with two restriction enzymes that cut different frequencies, representative fragments are generated within...
Abstract Purpose: A substantial contribution to the poor prognosis for head and neck squamous cell carcinoma (HNSCC) patients is progression distant metastasis. This occurs in 30% of over course their disease, radically reduces 5-year survival rate under 50%. Investigations recent years have begun unveil intricate interplay extracellular matrix (ECM) both tumor-intrinsic signaling immunoregulation. However, studies conducted context metastatic been limited. Here, we employ spatial...
Xanthomonas citri subsp. (Xcc) is a Gram-negative bacterium responsible for citrus canker, significant threat to crops. ClpV critical protein in the type VI secretion system (T6SS) as an ATPase involved bacterial motility, adhesion, and pathogenesis host some pathogenic bacteria. In order investigate function of clpV gene Xcc, clpV-deletion strain ΔclpV was constructed, its biological properties were evaluated, differences expression levels between wild-type analyzed by transcriptomics. The...
Objective: To investigate the correlations of laminin subunit gamma 3 (LAMC3) expression with prognosis ovarian cancer (OC). Methods: LAMC3 protein was measured using immunohistochemical streptavidin-peroxidase-biotin connection method (IHC). Gene and related clinical data in genome atlas (TCGA) cohort proteomic tumor analysis consortium (CPTAC) were applied to analyse correlation between gene expressions outcomes. Correlations clinicopathological factors evaluated Pearson χ2 test (2-sided)....