A5088070945- Immune Cell Function and Interaction
- Hematopoietic Stem Cell Transplantation
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Air Quality and Health Impacts
- CAR-T cell therapy research
- Renal Transplantation Outcomes and Treatments
- Asthma and respiratory diseases
- Diabetes and associated disorders
- Retinoids in leukemia and cellular processes
- Epigenetics and DNA Methylation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Advancements in Semiconductor Devices and Circuit Design
- Toxic Organic Pollutants Impact
- Cancer Immunotherapy and Biomarkers
- Eicosanoids and Hypertension Pharmacology
- Neonatal Respiratory Health Research
- Pharmacological Effects of Natural Compounds
- Mesenchymal stem cell research
- Synthesis of Tetrazole Derivatives
- Virus-based gene therapy research
- Noise Effects and Management
- Inflammation biomarkers and pathways
- Autophagy in Disease and Therapy
- Effects of Radiation Exposure
University of Minnesota
2014-2025
University of Minnesota System
2025
University of Minnesota Medical Center
2013-2022
Masonic Cancer Center
2015
Stanford University
2010-2014
Stanford Medicine
2010
Evidence suggests that exposure to polycyclic aromatic hydrocarbons (PAHs) increases atopy; it is unclear how PAH linked increased severity of atopic diseases.We hypothesized ambient impairment immunity in children (defined as with asthma and/or allergic rhinitis) from Fresno, California, an area elevated PAHs.We recruited 256 subjects CA. Ambient concentrations (ng/m(3) ) were measured using a spatial-temporal regression model over multiple time periods. Asthma diagnosis was determined by...
Regulatory T cells (Tregs) play a crucial role in the maintenance of peripheral tolerance. Quantitative and/or qualitative defects Tregs result diseases such as autoimmunity, allergy, malignancy, and graft-versus-host disease (GVHD), serious complication allogeneic stem cell transplantation (SCT). We recently reported increased expression autophagy-related genes (Atg) association with enhanced survival after SCT. Autophagy is self-degradative process for cytosolic components that promotes...
The clinical success of chimeric antigen receptor (CAR) T cell therapy for CD19+ B malignancies can be limited by acute toxicities and immunoglobulin replacement needs due to aplasia from persistent CAR cells. Life-threatening complications include cytokine release syndrome neurologic adverse events, the exact etiologies which are unclear. To elucidate underlying toxicity mechanisms test potentially safer cells, we developed a mouse model in human CD19 (hCD19)-specific cells were adoptively...
Abstract Non-lymphoid immunoregulatory cells, including mesenchymal stem cells (MSCs), myeloid-derived suppressor (MDSCs), regulatory macrophages (Mregs), and tolerogenic dendritic (Tol-DCs), play critical roles in maintaining immune homeostasis. However, their therapeutic application autoimmune diseases graft-versus-host disease (GVHD) has received comparatively less attention. Induced pluripotent (iPSCs) offer a promising platform for cell engineering, enabling superior quality control,...
Regulatory T cells (Tregs) are critical for maintaining immune homeostasis. However, current Treg immunotherapies do not optimally treat inflammatory diseases in patients. Understanding the cellular processes that control function may allow augmentation of therapeutic efficacy. In contrast to activated conventional cells, which protein kinase C-θ (PKC-θ) localizes contact point between and antigen-presenting human mouse Tregs, PKC-θ opposite end cell distal pole complex (DPC). Here, using a...
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) efficacy is complicated by graft-versus-host disease (GVHD), a leading cause of morbidity and mortality. Regulatory T cells (Tregs) have shown in preventing GVHD. However, high Treg doses are often required, necessitating substantial ex vivo or expansion that may diminish suppressor function. To enhance function, murine Tregs were transduced to express an anti-human CD19 chimeric antigen receptor (hCAR19) infused into lethally...
Damage to the gastrointestinal tract following allogeneic hematopoietic stem cell transplantation is a significant contributor severity and perpetuation of graft-versus-host disease. In preclinical models clinical trials, we showed that infusing high numbers regulatory T cells reduces disease incidence. Despite no change in vitro suppressive function, transfer ex vivo expanded transduced overexpress G protein-coupled receptor 15 or C-C motif chemokine 9, specific homing receptors for colon...
Abstract Regulatory T-cells (Tregs) prevent autoimmune and alloimmune reactions. Augmenting Treg function may enhance therapies for these diseases. Treg-specific inhibition of protein kinase C-theta (PKC-θ) enhances function. However, it is unclear whether PKC-θ can boost in systemic inflammatory conditions. In a mouse model acute GVHD, we found that Tregs treated with the inhibitor AEB071 reduced GVHD mortality severity significantly better than DMSO Tregs. Compared to DMSO, conventional...