A5013182368- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Hematopoietic Stem Cell Transplantation
- IL-33, ST2, and ILC Pathways
- Immunotherapy and Immune Responses
- Transplantation: Methods and Outcomes
- Glycosylation and Glycoproteins Research
- Immunodeficiency and Autoimmune Disorders
- Renal Transplantation Outcomes and Treatments
- Cervical Cancer and HPV Research
- Chronic Myeloid Leukemia Treatments
- Psoriasis: Treatment and Pathogenesis
- Chronic Lymphocytic Leukemia Research
- Ubiquitin and proteasome pathways
- Oral Health Pathology and Treatment
- Organ Donation and Transplantation
- Immune Response and Inflammation
- MicroRNA in disease regulation
- Hepatitis B Virus Studies
- Eosinophilic Esophagitis
- Renal and Vascular Pathologies
- Parkinson's Disease Mechanisms and Treatments
- Autism Spectrum Disorder Research
- Polyomavirus and related diseases
- Neurological Complications and Syndromes
CSL (United States)
2022-2024
University of Minnesota
2014-2019
University of Minnesota Medical Center
2014-2018
Masonic Cancer Center
2017
University of Pittsburgh
2010-2013
University of Maryland, Baltimore
2008
University of Pennsylvania
2008
Pennsylvania State University
2005
Immungenetics (Germany)
1998
Abstract Acute graft-versus-host disease (aGVHD) continues to be a frequent and devastating complication of allogeneic hematopoietic stem cell transplantation (HSCT), posing as significant barrier against the widespread use HSCTs curative modality. Recent studies suggested serum/plasma microRNAs (miRs) may predict aGVHD onset. However, little is known about functional role circulating miRs in aGVHD. In this article, we show two independent cohorts that miR-29a expression significantly...
Conclusion. Our results indicate that viral load may serve as an independent prognostic indicator for patients with HPV-16-associated squamous cell carcinoma of the tonsil. Objective. HPV-16 has gained increasing attention a possible causative agent Recent reports have indicated within tumor, along other factors, be correlated to patient survival. In this study, we sought examine indicator. Patients and methods. DNA was extracted from 35 tonsil samples determined by real-time PCR. The were...
Graft-versus-host disease (GVHD) is the major cause of nonrelapse morbidity and mortality after allogeneic stem cell transplantation (allo-SCT). Prevention treatment GVHD remain inadequate commonly lead to end-organ dysfunction opportunistic infection. The role interleukin (IL)-17 IL-22 in remains uncertain, due an apparent lack lineage fidelity variable contextually determined protective pathogenic effects. We demonstrate that donor T cell–derived significantly exacerbates cutaneous chronic...
Regulatory T cells (Tregs) are critical for maintaining immune homeostasis. However, current Treg immunotherapies do not optimally treat inflammatory diseases in patients. Understanding the cellular processes that control function may allow augmentation of therapeutic efficacy. In contrast to activated conventional cells, which protein kinase C-θ (PKC-θ) localizes contact point between and antigen-presenting human mouse Tregs, PKC-θ opposite end cell distal pole complex (DPC). Here, using a...
Soluble stimulation-2 (ST2) is increased during graft-versus-host disease (GVHD), while Tregs that express ST2 prevent GVHD through unknown mechanisms. Transplantation of Foxp3- T cells and were collected sorted from different Foxp3 reporter mice indicated in developed GVHD, ST2+ thymus derived predominantly localized to the intestine. ST2-/- Treg transplantation was associated with reduced total intestinal frequency activation. versus WT transcriptomes showed decreased functional markers...
Inbreeding depression and lack of genetic diversity in inbred mice could mask unappreciated causes graft failure or remove barriers to tolerance induction. To test these possibilities, we performed heart transplantation between outbred mice. Unlike untreated which all allografts were rejected acutely (6-16 days posttransplantation), had heterogeneous outcomes, with grafts failing early (<4 (6-24 days) undergoing chronic rejection (>75 days). Blocking T cell costimulation induced long-term...
Infusion of in vitro-derived T cell progenitor (proT) therapy with hematopoietic stem transplant aids the recovery thymus damaged by total body irradiation. To understand interaction between proTs and thymic microenvironment, WT mice were lethally irradiated given cell-deficient (Rag1-/-) marrow vitro-generated proTs, limiting mature development to infused proTs. ProTs within host led a significant increase epithelial cells (TECs) day 21 after transplant, increasing actively cycling TECs....
Acute graft-vs-host disease (aGVHD) is a serious complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT), yet there are limited data on the clinical and economic burden aGVHD in Germany. This real-world study aimed to evaluate outcomes among patients Germany with or without after allo-HSCT. retrospective cohort used administrative claims extracted from German statutory health insurance database. Eligible adult underwent allo-HSCT between 1 January 2009 31 December 2017...
Vaccines are beginning to be explored for as measures prevent cancer. Since determining the efficacy of vaccines by evaluating disease outcome requires a long time, there is an urgent need early predictive biomarkers. To this end, immunological endpoints that can assessed weeks or months post-vaccination currently being evaluated. However, when multiple available, waiting development humoral and cellular immunity could still cause delays, whereas assessments would allow timely shift more...
Abstract Chronic GVHD (cGVHD) is dependent on the ability of donor bone marrow (BM) B cells to produce pathogenic antibody (Ab) deposited in target organs, which associated with increased germinal centers (GCs). BTK necessary for enter GCs and ITK T cell activation. We hypothesized that alloreactive GC follicular helper require or inhibition by ibrutinib (Ib) would prevent cGVHD. evaluated therapeutic effect Ib two models cGVHD: a MHC-disparate (B6→B10.BR) multi-organ model complicated...
Abstract The inclusion of in vitro derived T cell progenitor (proT) therapy with hematopoietic stem transplant (HSCT) aids the recovery thymus damaged by total body irradiation and improves de novo thymopoiesis. To understand interaction between proTs thymic microenvironment, wildtype (WT) mice were lethally irradiated given deficient donor (Rag1−/−) marrow along generated proT from WT donors, limiting mature development to infused proT. Donor within host led a significant increase...
Abstract How IL-33-mediated signals impact on ST2-expressing regulatory T cell (Treg) expansion and functions is poorly understood. To establish the importance of direct IL-33 stimulation Treg for control alloimmune responses, we utilized a rodent model graft-vs. host disease (GVHD) where C57BL/6 mice were irradiated given BALB/c bone marrow transplant (BMT) along with CD4+ CD25+ from st2+/+ or st2−/− at 1:2 ratio WT CD3+ effector cells. As expected, cells promoted full protection against...
Abstract Graft-versus-host disease (GVHD) is the leading complication and cause of mortality after allogeneic hematopoietic cell transplantation (allo-HCT). Recently, we reported that IL-33 released from tissue damaged during allo-HCT conditioning mediates pro-inflammatory responses by Teffector cells resulting in greater acute GVHD lethality clinical symptoms mice. However, a pleiotropic cytokine both anti-inflammatory responses. We hypothesized beneficial effects mediated could be...