A5035423192- Immune Cell Function and Interaction
- CAR-T cell therapy research
- IL-33, ST2, and ILC Pathways
- T-cell and B-cell Immunology
- Advancements in Battery Materials
- Advanced Battery Materials and Technologies
- RNA Interference and Gene Delivery
- Immunotherapy and Immune Responses
- Viral Infectious Diseases and Gene Expression in Insects
- Immune cells in cancer
- Virus-based gene therapy research
- Cancer Immunotherapy and Biomarkers
- Hematopoietic Stem Cell Transplantation
- Rock Mechanics and Modeling
- Geotechnical and Geomechanical Engineering
- Supercapacitor Materials and Fabrication
- Cytokine Signaling Pathways and Interactions
- Advanced Battery Technologies Research
- Landslides and related hazards
- Eosinophilic Esophagitis
- Acute Myeloid Leukemia Research
- Asthma and respiratory diseases
- Immune Response and Inflammation
- Catalytic Processes in Materials Science
- Protein Degradation and Inhibitors
Xi'an Jiaotong University
2022-2025
Karlsruhe Institute of Technology
2024-2025
Chongqing University
2022-2024
Indiana University – Purdue University Indianapolis
2014-2024
Indiana University School of Medicine
2015-2024
Indiana University
2017-2024
Houston Methodist
2018-2023
Jilin University
2010-2023
Henan University
2023
China State Construction Engineering (China)
2022-2023
Tumor-associated myeloid cells maintain immunosuppressive microenvironments within tumors. Identification of myeloid-specific receptors to modulate tumor-associated macrophage and myeloid-derived suppressor cell (MDSC) functions remains challenging. The leukocyte immunoglobulin-like receptor B (LILRB) family members are negative regulators activation. We investigated how LILRB targeting could function. LILRB2 antagonism inhibited receptor-mediated activation SHP1/2 enhanced proinflammatory...
Ni-rich layered oxides are one of the most attractive cathode materials in high-energy-density lithium-ion batteries, their degradation mechanisms still not completely elucidated. Herein, we report a strong dependence pathways on long-range cationic disordering Co-free Li1-m (Ni0.94 Al0.06 )1+m O2 (NA). Interestingly, disordered phase with lattice mismatch can be easily formed near-surface region NA particles very low cation disorder (NA-LCD, m≤0.06) over electrochemical cycling, while...
Graft-versus-host disease (GVHD) remains a devastating complication after allogeneic hematopoietic cell transplantation (HCT). We previously identified high plasma soluble suppression of tumorigenicity 2 (sST2) as biomarker the development GVHD and death. sST2 sequesters interleukin-33 (IL-33), limiting its availability to T cells expressing membrane-bound ST2 (mST2) [T helper (TH2) ST2(+)FoxP3(+) regulatory cells]. report that blockade in peritransplant period with neutralizing monoclonal...
Ni-rich layered oxide cathode materials are promising candidates for high-specific-energy battery systems owing to their high reversible capacity. However, widespread application is still severely impeded by severe capacity loss upon long-term cycling. It has been proven that the cyclic stability of closely related microstructure and morphology. Despite this, influence primary particles on fatigue mechanism during prolonged cycling not fully understood. Here, two spherical agglomerate oxides...
Allergic asthma is a chronic lung disease characterized by airway hyperresponsiveness and cellular infiltration that exacerbated immunoglobulin E-dependent mast cell (MC) activation. Interleukin-9 (IL-9) promotes MC expansion during allergic inflammation but precisely how IL-9 expands tissue MCs function unclear. In this report, using multiple models of inflammation, we show both mature (mMCs) progenitors (MCp) express IL-9R respond to inflammation. acts on MCp in the bone marrow lungs...
Among the cytokines regulating immune cells, IL-9 has gained considerable attention for its ability to act on multiple cell types as a regulator of beneficial and pathologic responses. Yet, it is still not clearly defined how impacts demonstrates remarkable degree tissue-specific functionality cellular sources that vary by tissue site context inflammatory milieu. Here, we provide perspective summarize biological activities highlight type-specific roles in pathogenesis diseases. This will be...
Abstract O2‐type layered oxides have emerged as promising cathode materials for high‐energy lithium‐ion batteries, offering a solution to mitigate voltage decay through reversible transition metal (TM) migration between TM and Li layers during cycling. However, achieving fully oxygen redox remains significant challenge. Here, this is addressed by introducing Li─O─Li configurations in the structure of 0.85□0.15 [Li 0.08□0.04 Ni 0.22 Mn 0.66 ]O 2 (O2‐LLNMO), where □ represents vacancies. This...
Abstract Li‐ and Mn‐rich layered oxides exhibit high specific capacity due to the cationic anionic reaction process during high‐voltage cycling (≥4.6 V). However, they face challenges such as low initial coulombic efficiency (~70 %) poor stability. Here, we propose a combination of H 3 BO treatment temperature calcination construct shell with vacancy on surface Li 1.2 Ni 0.2 Mn 0.6 O 2 (LLNMO). The produces lattice distortion, forming an oxidized n − (0< <2) surface, accompanied by...
Li- and Mn-rich layered oxides exhibit high specific capacity due to the cationic anionic reaction process during high-voltage cycling (≥4.6 V). However, they face challenges such as low initial coulombic efficiency (~70 %) poor stability. Here, we propose a combination of H3BO3 treatment temperature calcination construct shell with vacancy on surface Li1.2Ni0.2Mn0.6O2 (LLNMO). The produces lattice distortion, forming an oxidized On- (0<n<2) surface, accompanied by electrons redistribution....
Gastrointestinal graft-versus-host-disease (GI-GVHD) is a life-threatening complication occurring after allogeneic hematopoietic cell transplantation (HCT), and blood biomarker that permits stratification of HCT patients according to their risk developing GI-GVHD would greatly aid treatment planning. Through in-depth, large-scale proteomic profiling presymptomatic samples, we identified T population expressing both CD146, adhesion molecule, CCR5, chemokine receptor upregulated as early 14...
Composite connections are important components of timber-concrete hybrid systems. This work presents a novel shear connector for composite (TCC) connections. To verify the action between timber and concrete in proposed connection, ten specimens were subjected to push-out tests examine slip at interlayer. The failure mode maximum load capacity results analyzed, indicating that have good ductility high capacity. Four methods determine yield point compared discussed detail. According test...
Soluble cytokine receptors function as decoy to attenuate cytokine-mediated signaling and modulate downstream cellular responses. Dysregulated overproduction of soluble can be pathological, such ST2 (sST2), a prognostic biomarker in cardiovascular diseases, ulcerative colitis, graft-versus-host disease (GVHD). Although intervention using an antibody improves survival murine GVHD models, sST2 is challenging target for drug development because it binds IL-33 via extensive interaction...
Abstract Although IL-9 has potent anti-tumor activity in adoptive cell transfer therapy, some models suggest that it can promote tumor growth. Here, we show signaling is associated with poor outcomes patients various forms of lung cancer, and required for growth multiple mouse models. CD4 + T cell-derived promotes the expansion both CD11c − interstitial macrophage populations Mechanistically, IL-9/macrophage axis requires arginase 1 (Arg1) to mediate Indeed, Arg1 but not - macrophages Il9r...
O2-type Li-rich layered oxides (LLOs) typically display stable cyclic properties and low voltage decay owing to the reversible migration of transition metals (TMs) between face-shared TMO6 LiO6. However, intrinsic relationship microstrain in LLOs remains unclear. Herein, an manganese-based cathode material, Li2/3□1/3Ni0.25Mn0.75O2 (LNMO-RT), is synthesized through a Li+/Na+-ion exchange reaction at room temperature. The phase from P2-type structure induces significant change unit-cell...
Soluble stimulation-2 (ST2) is increased during graft-versus-host disease (GVHD), while Tregs that express ST2 prevent GVHD through unknown mechanisms. Transplantation of Foxp3- T cells and were collected sorted from different Foxp3 reporter mice indicated in developed GVHD, ST2+ thymus derived predominantly localized to the intestine. ST2-/- Treg transplantation was associated with reduced total intestinal frequency activation. versus WT transcriptomes showed decreased functional markers...