A5022710700- Melanoma and MAPK Pathways
- Cytokine Signaling Pathways and Interactions
- Immune Cell Function and Interaction
- NF-κB Signaling Pathways
- Cancer Research and Treatments
- Immune Response and Inflammation
- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Treatments and Studies
- Cancer Cells and Metastasis
- Cutaneous Melanoma Detection and Management
- IL-33, ST2, and ILC Pathways
- Galectins and Cancer Biology
- Nonmelanoma Skin Cancer Studies
- Enterobacteriaceae and Cronobacter Research
- RNA modifications and cancer
- 14-3-3 protein interactions
- Seaweed-derived Bioactive Compounds
- Single-cell and spatial transcriptomics
- Protein Tyrosine Phosphatases
- Cancer, Lipids, and Metabolism
Mount Sinai Hospital
2020
Icahn School of Medicine at Mount Sinai
2020
Centro Nacional de Biotecnología
2012-2018
Consejo Superior de Investigaciones Científicas
2012-2016
Tumor-associated myeloid cells maintain immunosuppressive microenvironments within tumors. Identification of myeloid-specific receptors to modulate tumor-associated macrophage and myeloid-derived suppressor cell (MDSC) functions remains challenging. The leukocyte immunoglobulin-like receptor B (LILRB) family members are negative regulators activation. We investigated how LILRB targeting could function. LILRB2 antagonism inhibited receptor-mediated activation SHP1/2 enhanced proinflammatory...
On the basis mainly of pharmacological experiments, p38α MAP kinase isoform has been established as an important regulator immune and inflammatory responses. However, role related p38γ p38δ kinases remained unclear. Here, we show that deletion impaired innate response to lipopolysaccharide (LPS), a Toll-like receptor 4 (TLR4) ligand, by blocking extracellular signal-regulated 1/2 (ERK1/2) activation in macrophages dendritic cells. were necessary maintain steady-state levels tumor progression...
p38 MAPK signaling has been implicated in the regulation of processes leading to cancer development and progression. Chronic inflammation is a known risk factor for tumorigenesis, yet precise mechanism this association remains largely unknown. The related p38αMAPK (MAPK14) proteins p38γ (MAPK12) p38δ (MAPK13) were recently shown modulate immune response, although their role tumorigenesis controversial function inflammation-associated not studied. We analyzed colon associated colitis using...
The role of most p38 MAPK isoforms in inflammatory arthritis is not known. This study was undertaken to evaluate p38γ and p38δ deficiency the collagen-induced (CIA) model.Wild-type, p38γ(-/-) , p38δ(-/-) p38γ/δ(-/-) mice were immunized with chicken type II collagen, disease activity evaluated by semiquantitative scoring histologic assessment. Serum cytokine levels vitro T cell responses quantified flow cytometry multiplex analysis, serum anticollagen antibody enzyme-linked immunosorbent...
// Rafal Zur 1 , Laura Garcia-Ibanez Angel Nunez-Buiza Noelia Aparicio Georgios Liappas 2 Alejandra Escós Ana Risco Angustias Page 3 Cristina Saiz-Ladera Dayanira Alsina-Beauchamp José Montans 4 Jesús M. Paramio and Cuenda Department of Immunology Oncology, Centro Nacional de Biotecnología/CSIC, Madrid, Spain Molecular Biology Centre Severo Ochoa/CSIC-UAM, Oncology Unit, CIEMAT I+12 Biomedical Research Institute, University Hospital 12 Octubre, Anatomopatológico, Camino Vinateros,...
Research Article16 April 2018Open Access Source DataTransparent process Myeloid cell deficiency of p38γ/p38δ protects against candidiasis and regulates antifungal immunity Dayanira Alsina-Beauchamp Department Immunology Oncology, Centro Nacional de Biotecnología/CSIC, Madrid, Spain Search for more papers by this author Alejandra Escós orcid.org/0000-0002-2990-7920 Pilar Fajardo Diego González-Romero Ester Díaz-Mora Ana Risco Miguel A Martín-Serrano Carlos del Fresno Immunobiology...
ABSTRACT It is well known that the expansion of mammary epithelium during ovarian cycles in female mammals supported by transient increase epithelial stem cells (MaSCs). However, dissecting molecular mechanisms govern MaSC function and differentiation poorly understood due to lack standardized methods for their identification isolation. The development robust single-cell mRNA sequencing () technologies computational analyze them provides us with novel tools approach challenge studying MaSCs...
<p>Figure S1. Effect of p38gamma and p38delta deletion in early stages colitis-associated colon cancer induced by AOM/DSS treatment. Figure S2. p38deltaexpression AOM/DSS-treated untreated mouse colon. WT, /-, p38delta/- or p38gamma/delta/- mice were untreated. At 9 weeks post-AOM injection, extracts prepared for mRNA protein analysis. S3. p38deltadeletion has no significant effect on body weight length the course DSS-induced colitis. WT treated with 3% DSS drinking water 5 days. S4....
<p>Figure S1. Effect of p38gamma and p38delta deletion in early stages colitis-associated colon cancer induced by AOM/DSS treatment. Figure S2. p38deltaexpression AOM/DSS-treated untreated mouse colon. WT, /-, p38delta/- or p38gamma/delta/- mice were untreated. At 9 weeks post-AOM injection, extracts prepared for mRNA protein analysis. S3. p38deltadeletion has no significant effect on body weight length the course DSS-induced colitis. WT treated with 3% DSS drinking water 5 days. S4....
<div>Abstract<p>p38 MAPK signaling has been implicated in the regulation of processes leading to cancer development and progression. Chronic inflammation is a known risk factor for tumorigenesis, yet precise mechanism this association remains largely unknown. The related p38αMAPK (MAPK14) proteins p38γ (MAPK12) p38δ (MAPK13) were recently shown modulate immune response, although their role tumorigenesis controversial function inflammation-associated not studied. We analyzed colon...
<div>Abstract<p>p38 MAPK signaling has been implicated in the regulation of processes leading to cancer development and progression. Chronic inflammation is a known risk factor for tumorigenesis, yet precise mechanism this association remains largely unknown. The related p38αMAPK (MAPK14) proteins p38γ (MAPK12) p38δ (MAPK13) were recently shown modulate immune response, although their role tumorigenesis controversial function inflammation-associated not studied. We analyzed colon...