A5077719330- Asthma and respiratory diseases
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- IL-33, ST2, and ILC Pathways
- Immune Response and Inflammation
- Allergic Rhinitis and Sensitization
- Diabetes and associated disorders
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Salivary Gland Disorders and Functions
- Dermatology and Skin Diseases
- Cancer Immunotherapy and Biomarkers
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Disaster Management and Resilience
- Oral microbiology and periodontitis research
- Pediatric health and respiratory diseases
- Mast cells and histamine
- Mycobacterium research and diagnosis
- Pancreatitis Pathology and Treatment
- Viral Infectious Diseases and Gene Expression in Insects
- Exercise and Physiological Responses
Indiana University – Purdue University Indianapolis
2020-2023
Indiana University School of Medicine
2020-2023
University of Florida
2017-2021
Indiana University
2020
University of Indianapolis
2020
Center for Children
2019
Asthma is a chronic inflammatory lung disease with intermittent flares predominately mediated through memory T cells. Yet, the identity of long-term cells that mediate allergic recall responses not well defined. In this report, using mouse model allergen exposure followed by an allergen-free rest period, we characterized subpopulation CD4+ secreted IL-9 as obligate effector cytokine. IL-9-secreting had resident cell phenotype, and blocking during challenge or deleting from significantly...
Signal transducer and activator of transcription 4 (STAT4) is expressed in hematopoietic cells plays a key role the differentiation T helper 1 cells. Although STAT4 required for immunity to intracellular pathogens, cell-independent protective mechanisms are not clearly defined. In this report, we demonstrate that STAT4-deficient mice were acutely sensitive methicillin-resistant Staphylococcus aureus (MRSA) infection. We show was neutrophils activated by IL-12 via JAK2-dependent pathway....
Allergic asthma is a chronic lung disease characterized by airway hyperresponsiveness and cellular infiltration that exacerbated immunoglobulin E-dependent mast cell (MC) activation. Interleukin-9 (IL-9) promotes MC expansion during allergic inflammation but precisely how IL-9 expands tissue MCs function unclear. In this report, using multiple models of inflammation, we show both mature (mMCs) progenitors (MCp) express IL-9R respond to inflammation. acts on MCp in the bone marrow lungs...
Abstract Antigen (Ag)-specific tolerization prevents type 1 diabetes (T1D) in non-obese diabetic (NOD) mice but proved less effective humans. Several auto-Ags are fundamental to disease development, suggesting T1D etiology is heterogeneous and may limit the effectiveness of Ag-specific therapies distinct endotypes. Colonization factor antigen I (CFA/I) fimbriae from Escherichia coli can inhibit autoimmune diseases murine models by inducing bystander tolerance. To test if Ag-independent...
Abstract Background Sjögren’s syndrome (SjS), one of the most common autoimmune diseases, impacts millions people annually. SjS results from attack on exocrine (salivary and lacrimal) glands, women are nine times more likely to be affected than men. To date, no vaccine or therapeutic exists treat SjS, patients must rely lifelong therapies alleviate symptoms. Methods Oral treatment with adhesin enterotoxigenic Escherichia coli colonization factor antigen I (CFA/I) fimbriae protects against...
Abstract Chimeric antigen receptor (CAR) T cell therapy involves genetically manipulating cells to express an specific for tumor protein, resulting in a powerful anti-cancer therapeutic. However, trafficking sites and the suppressive nature of microenvironment have prevented effective treatment solid tumors. Previous work has shown that helper (Th) subsets variable killing capabilities, however, it is not completely defined how different transcriptional differentiation programs effect...
Allergic skin inflammation requires the influx of inflammatory cells into skin. Extravasation leukocytes interactions between endothelial selectins and their glycan ligands on surface leukocytes. Selectin-ligand formation activity several glycosyltransferases, including Fut7 In this report, we tested importance for development allergic in Stat6VT transgenic mouse model. We observed that deficiency was protective but did not eliminate disease. Segregation data by gender parent transmitted...
Abstract Oral treatment with the adhesin from enterotoxigenic E. coli, CFA/I fimbriae protect in murine models of multiple sclerosis and rheumatoid arthritis. Although initial mode action is a bystander or an antigen (Ag)-independent fashion, protection was found to be ultimately dependent upon induction and/or activation auto-Ag-specific regulatory T cells (Tregs). Our recent findings show that oral dosing L. lactis vector expressing (LL-CFA/I) reduces incidence T1D NOD mice by 45%...
Abstract Type 1 diabetes (T1D) is an autoimmune disease in which insulin-producing pancreatic β cells are destroyed by auto-aggressive T cells. Tregs T1D have been shown to lose their suppressive function and/or become inflammatory, complicating Treg immunotherapy. Oral treatment with the adhesin from enterotoxigenic E. coli, CFA/I fimbriae, protects against autoimmunity. Although fimbriae act a bystander or antigen (Ag)-independent fashion, protection ultimately dependent upon induction...
Background and Hypothesis: Chimeric antigen receptors (CARs) are recombinant with high affinity for the target antigen. Used tumor therapy, CARs transduced into patient T cells. CAR-T cells specific CD19 used to treat B cell acute lymphoblastic leukemia (B-ALL). Cancerous destroyed by in an antigen-specific manner. Currently being conjunction radiation other cancer therapies prohibit relapse, Dr. Marco Davila of Moffitt Cancer Center, has shown that therapy induces long term remission...
Abstract Sjögren’s syndrome (SjS) is one of the most common autoimmune diseases impacting several million people every year in US. SjS results from attack exocrine (salivary and lacrimal) glands, women are nine times more likely to be affected than men. To date, no vaccine or therapeutic exists cure SjS, patients must rely on lifelong therapies treat symptoms. Oral treatment with adhesin enterotoxigenic E. coli CFA/I fimbriae has been shown protect against an antigen (Ag)-independent manner....
Abstract Allergic asthma is a chronic intermittent inflammatory lung disease where patients experience relatively few symptoms between exacerbations precipitated by allergen-challenge of allergic memory responses. Allergen-specific CD4+ T cells are believed to be major mediator responses through the production type 2 cytokines including IL-4, IL-5, IL-13 and IL-9. Recently, tissue-resident (Trm) have been identified in peripheral tissues that mediate mucosal barrier immunity. However,...