A5082014053- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Asthma and respiratory diseases
- CAR-T cell therapy research
- Reproductive System and Pregnancy
- Dermatology and Skin Diseases
Indiana University – Purdue University Indianapolis
2023-2025
Indiana University School of Medicine
2023-2025
Abstract Although disparity in breast cancer outcomes women of African Ancestry (AA) as compared to European (EA) has been thought derive from socioeconomic factors, emerging evidence demonstrating genetic ancestry-dependent differences normal and genome, cancer-associated mutation patterns immunosuppressed tumor microenvironment suggests the involvement biological factors. To investigate outcome-associated biologic we analyzed tissues healthy donors distinct ancestry found that PROCR+/...
Atopic dermatitis results in diminished barrier function and altered production of antimicrobial peptides. Dendritic epidermal T cells (DETCs) play an important role the wound repair inflammation process. Our previous work identified IL-4-dependent loss DETCs Stat6VT mice MC903-induced skin mouse model. However, mechanisms through which IL-4 mediates are unclear. In this study, we show that IL-4Rα germline knockout (Il4ra-/-) have increased DETCs, faster healing, differentiation complex gene...
Abstract The polarization of naive Th cells into differentiated subsets in vitro was a powerful approach to define the development and function vivo. cell cultures identified cytokines that promote defined phenotype stability cells. One limitations this is heterogeneity culture, essentially with regard what proportion culture secreting hallmark cytokine interest. This has always been puzzling because all have exposed identical conditions. We examined phenomenon using an Il17f lineage-tracing...