A5031578126- Neural dynamics and brain function
- Animal Vocal Communication and Behavior
- Advanced Memory and Neural Computing
- Hearing, Cochlea, Tinnitus, Genetics
- Photoreceptor and optogenetics research
- Neuroscience and Neural Engineering
- Bat Biology and Ecology Studies
- Neuroendocrine regulation and behavior
- Hearing Loss and Rehabilitation
- Wireless Body Area Networks
- Electromagnetic Fields and Biological Effects
- Neuroscience and Neuropharmacology Research
- EEG and Brain-Computer Interfaces
- Retinal Development and Disorders
- Neural and Behavioral Psychology Studies
- Electrochemical Analysis and Applications
- Analytical Chemistry and Sensors
- Viral Infections and Vectors
- T-cell and B-cell Immunology
- Wireless Power Transfer Systems
- Planarian Biology and Electrostimulation
- Neuroscience of respiration and sleep
- Environmental Impact and Sustainability
- Human-Animal Interaction Studies
- Marine animal studies overview
University of Colorado Denver
2021-2025
University of Colorado Anschutz Medical Campus
2021-2025
University of Macau
2015-2025
Institute of Microelectronics
2025
Jilin University
2021-2024
Shandong University of Science and Technology
2022
Electrophysiological recording of neurons in deep brain regions using optogenetic stimulation is a powerful method for understanding and regulating the role complex neural activity biological behavior cognitive function. Optogenetic techniques have significantly advanced neuroscience research by enabling optical manipulation activities. Because significance technique, constant advancements implantable optrodes that integrate with low-noise, large-scale electrophysiological are demand to...
This study introduces an in-vivo optogenetic manipulation approach for the medial nucleus of trapezoid body (MNTB) in Mongolian gerbils, a species with hearing range similar to humans. The MNTB is crucial sound localization, but traditional methods lack temporal precision and reversibility. aim this develop specific, reversible method controlling activity fast precise control, vital studying localization. We stereotactically injected adeno-associated viral vectors encoding opsins into gerbil...
The hearing abilities of mammals are impacted by factors such as social cues, habitat, and physical characteristics. Despite being used commonly to study behaviors, the monogamous prairie vole (Microtus ochrogaster) has never been characterized. In this study, anatomical features measured auditory brainstem responses (ABRs) measure capabilities voles, characterizing monaural binaural range. Sexually naive male female voles were characterize differences due sex. It was found that show a range...
With the ratification of Paris Agreement at Climate Conference, reducing carbon emissions has become a global interest. Coal is one main industries causing emissions; thus, quantifying from coal mining an important step in these emissions. Firstly, based on life cycle idea, this paper, we define Carbon Emission Boundary fully mechanized method. Secondly, emission accounting model (B-R model) established, which includes total amount and each link during process. The Fifth-II area Jinda Mine...
Abstract Aim Oxytocin plays an important role in social recognition rodents, which is mediated predominantly by the olfactory system. Although oxytocin modulates neural activity bulb, underlying mechanism largely unknown. Here, we studied how direct infusion of into bulb affect interactions mice and modulate mitral/tufted cells bulb. Methods A three‐chamber interaction test was used behavioural test. For vivo studies, single unit recordings, local field potential recordings fibre photometry...
Non-invasive stimulation of biological tissue is highly desirable for several biomedical applications. Of specific interest are methods tumor treatment, endometrial ablation, and neuro-modulation. In traditional neuro-modulation, single- multi-coil transcranial techniques in low oscillation frequencies utilized to non-invasively penetrate the skull elicit action potentials cortical neurons. Although these have been proven effective, tightly focusing signals localized regions difficult....
Human alpha oscillation (7-13 Hz) has been extensively studied over the years for its connection with cognition. The individual frequency (IAF), defined as that provides highest power in band, shows a positive correlation cognitive processes. modulation of activities accomplished through various approaches aimed at improving performance. However, very few studies focused on direct IAF by shifting peak frequency, and understanding remains highly limited. In this study, IAFs healthy young...
Age-related hearing loss is a global health problem of increasing importance. While the role peripheral well understood and treatments are available, central loss, ability brain to make sense sound, much less no available. We report on age-related alterations in auditory stem which compromise listener's isolate sound from competing background noises, for example crowded restaurant. Sound localization depends extreme temporal precision order microseconds, pathway shows several specializations...
. The OSort algorithm, a pivotal unsupervised spike sorting method, has been implemented in dedicated hardware devices for real-time sorting. However, due to the inherent complexity of neural recording environments, still grapples with numerous transient cluster occurrences during practical process. This leads substantial memory usage, heavy computational load, and complex architectures, especially noisy recordings multi-channel systems.
Spatial hearing allows animals to rapidly detect and localize auditory events in the surrounding environment. The brainstem plays a central role processing extracting binaural spatial cues through microsecond-precise integration, especially for detecting interaural time differences (ITDs) of low-frequency sounds at medial superior olive (MSO). A series mechanisms exist underlying neural circuits preserving accurate action potential timing across multiple fibers, synapses nuclei along this...
Highlights•Pre-synaptic short-term plasticity is impaired in Aux-KO mice•Orientation selectivity and visual mismatch responses are reduced mice•Visual familiarity-induced oscillations mice•Optokinetic miceSummaryAuxilin (DNAJC6/PARK19), an endocytic co-chaperone, essential for maintaining homeostasis the readily releasable pool (RRP) by aiding clathrin-mediated uncoating of synaptic vesicles. Its loss-of-function mutations, observed familial Parkinson's disease (PD), lead to basal ganglia...
The mammalian olfactory system uses odor-specified temporal codes to represent the quality and quantity of different odors. In order better understand this coding strategy, a biologically plausible spiking neural network (SNN) was built evaluated. study, MNIST images handwritten digits were used mimic two-dimensional representation odor information by glomeruli in bulb. train SNN based on spike-timing-dependent plasticity (STDP) unsupervised learning rule. model implemented Izhikevich...
The auditory brainstem response (ABR) is a widely used objective electrophysiology measure for non-invasively assessing function and neural activities in the brainstem, but its ability to reflect detailed neuronal processes limited due averaging nature of electroencephalogram recordings. This study addresses this limitation by developing computational model which capable synthesizing ABR traces based on large, population scale extrapolation spiking network circuitry. was able recapitulate...
Electrophysiological recordings of neurons in deep brain regions using optogenetic stimulation are essential to understanding and regulating the role complex neural activity biological behavior cognitive function. Optogenetic techniques have significantly advanced neuroscience research by enabling optical manipulation activities. Because significance technique, constant advancements implantable optrodes that integrate with low-noise, large-scale electrophysiological recording demand improve...
ABSTRACT The genus Peromyscus has been extensively used as a model for ecological, behavioral, and evolutionary investigations. We auditory brainstem responses (ABRs), craniofacial morphology, pinna measurements to compare characteristics that impact hearing in two wild-caught species, P. leucopus maniculatus . observed significant statistical differences attributes between species with overall exhibiting larger features than ABR recordings indicated both showed similar best frequency...
Abstract The characteristics of an animal’s head and pinna mark the beginning auditory communication. Auditory communication is broadly achieved by receiving sounds from environment plays a vital role in ability to perceive localize sounds. Natural history museums collections along with their vast repositories specimens provide unique resource for examining how variability both size shape cause detection acoustic signals across species. Using this approach, we measured dimensions over 1,200...
Flickering video clips can be used as stimuli in Steady state visual evoked potential (SSVEP)-based brain-computer interfaces (BCIs) with potentially high performance. This study aims to investigate the effectiveness of using various types different emotional valences, scenes and actors' actions. Experimental result showed that flickering videos affective contents enhance SSVEP response compared neutral stimuli. Furthermore, pleasant unpleasant have similar effects. More interestingly, among...
ABSTRACT Hearing ability of mammals can be impacted by many factors including social cues, environment, and physical properties animal morphology. Despite being used commonly to study behaviors, hearing the monogamous prairie vole ( Microtus ochrogaster ) has never been fully characterized. In this study, we measure morphological head pinna features use auditory brainstem responses capabilities voles characterizing monaural binaural range. Additionally, measured unbonded male female...
Auxilin, the endocytic co-chaperone, plays a crucial role in maintaining homeostasis of readily releasable pool (RRP) by facilitating clathrin uncoating synaptic vesicles. Auxilin (DNAJC6/PARK19) loss-of-function mutations are associated with familial Parkinson’s Disease (PD). Besides basal ganglia motor deficits, cortical dysfunction is prevalent PD patients. Here, we took multifaceted experimental approach to identify neurophysiological deficits underlying these dysfunctions. We analyzed...