A5051678937- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Hereditary Neurological Disorders
- Obsessive-Compulsive Spectrum Disorders
- Cancer Genomics and Diagnostics
- Hepatocellular Carcinoma Treatment and Prognosis
- Autism Spectrum Disorder Research
- PI3K/AKT/mTOR signaling in cancer
Huazhong University of Science and Technology
2018-2025
Jiujiang First People's Hospital
2023
Tongji Hospital
2018
Tourette’s syndrome (TS) is a major neurodevelopmental disorder characterized by childhood-onset motor and vocal tics. A W88C mutation in WWC1 gene notable risk factor for TS, but the underlying molecular mechanisms remain unclear due to lack of suitable animal models. Here, we generate mutant mouse line with human (W88C Mut mice), which exhibits behavioral deficits similar those observed patients including repetitive behaviors sensorimotor gating abnormalities. The leads degradation kidney...
Circular RNAs (circRNAs) have been shown to critical roles in developing cancer and treatment resistance an increasing body of research. The aim was look into the functions processes hsa_circ_0003220 non-small cell lung (NSCLC) chemoresistance. NSCLC lines H460 A549 were employed present work. hsa_circ_0003220, miR-489-3p, insulin-like growth factors (IGF1) mRNA levels assessed with a quantitative real time polymerase chain reaction (qRT-PCR). cisplatin, docetaxel, paclitaxel (PTX)...
Background. Tumor progression and the therapeutic resistance associated with cancer agents are thought to be modulated by circular RNAs (circRNAs); however, its mechanism nonsmall cell lung (NSCLC) is still undetermined. The following investigation aimed evaluate involvement of circRNAs NSCLC. Methods. serum specimens 146 NSCLC individuals who received complete four cycles PTX chemotherapy were collected. concentration hsa_circ_0005962 these was assessed quantitative real-time polymerase...
Circular RNAs (circRNAs) demonstrated critical roles within developing tumors and treatment resistance in an increasing body of research. The aim was to look into the functions processes hsa_circ_0003489 non-small cell lung cancer (NSCLC) paclitaxel (PTX) resistance.NSCLC cell-based cultures including A549 H460 were employed for such investigation. hsa_circ_0003489, miR-98-5p, insulin-like growth factor 2 (IGF2) expression-profiles evaluated with a quantitative real-time polymerase chain...