A5014406711- Vasculitis and related conditions
- Renal Diseases and Glomerulopathies
- Mesenchymal stem cell research
- Effects of Environmental Stressors on Livestock
- Cancer-related molecular mechanisms research
- Plant biochemistry and biosynthesis
- Adipose Tissue and Metabolism
- Chronic Kidney Disease and Diabetes
- Circular RNAs in diseases
- Extracellular vesicles in disease
- S100 Proteins and Annexins
- Dialysis and Renal Disease Management
- Seed and Plant Biochemistry
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Inflammasome and immune disorders
- Mitochondrial Function and Pathology
- Genetic and phenotypic traits in livestock
- Pregnancy and Medication Impact
- RNA modifications and cancer
- Genomics, phytochemicals, and oxidative stress
- Livestock Management and Performance Improvement
- Systemic Sclerosis and Related Diseases
- Sarcoidosis and Beryllium Toxicity Research
- Vitamin K Research Studies
- Ginseng Biological Effects and Applications
Second Affiliated Hospital of Jilin University
2021-2024
National Clinical Research Center for Digestive Diseases
2024
Air Force Medical University
2024
Xijing Hospital
2024
University of Alberta
2022-2023
Sichuan Agricultural University
2022-2023
General Hospital of Shenyang Military Region
2023
Ministry of Agriculture and Rural Affairs
2023
First Affiliated Hospital of Bengbu Medical College
2023
Chengdu University
2023
Objective: To elucidate the potential causality of leukocyte telomere length (LTL) with immune-mediated inflammatory diseases (IMIDs), we conducted a Mendelian randomization (MR) study. Methods: The genetically predicted causation between LTL and IMIDs was evaluated using two-sample MR method. We analyzed 16 major IMIDs, which included systemic lupus erythematosus (SLE), bowel disease (IBD), ulcerative colitis (UC), Crohn's (CD), ankylosing spondylitis (AS), sicca syndrome (SS), rheumatoid...
Ischemia induces angiogenesis as a compensatory response. Although ischemia is known to causes synthesis and release of calcitonin gene-related peptide (CGRP), it not clear whether CGRP regulates under how does function. Thus we investigated the role in involved mechanisms. We found that level was increased rat hindlimb ischemic tissue. The expression exogenous by adenovirus vectors enhanced blood flow recovery capillary density hindlimbs. In vitro, promoted human umbilical vein endothelial...
Abstract Background Mesenchymal stem cells (MSCs) have a therapeutic effect on diabetic nephropathy (DN) but the underlying mechanism remains unclear. This study was conducted to investigate whether human umbilical cord-MSCs (hUCMSCs) can induce oxidative damage and apoptosis by activating Nrf2. Methods We used type 2 rat model high-glucose fat-stimulated glomerular mesangial cell (hGMC) model. Western blotting, RT-qPCR, TUNEL staining were performed animal tissues cultured cells. Nuclear...
Introduction: In this study estimated genetic and phenotypic correlations between fifteen complete blood count (CBC) traits thirty-three heritable plasma metabolites in young healthy nursery pigs. addition, it provided an opportunity to identify candidate genes associated with variation metabolite concentration their potential association immune response, disease resilience, production traits. Methods: The samples were collected from pigs Nuclear Magnetic Resonance (NMR) was used quantify...
Abstract Objective We investigated the correlation between zinc levels and Nrf2 expression potential effects on clinicopathology of patients with diabetic nephropathy (DN). Methods selected 30 DN, diagnosed via renal biopsy at our hospital from March 2018 to November 2019, enrolled healthy individuals a medical examination center as control group. Patients DN were divided into normal-zinc low-zinc groups. detected zinc, copper, mRNA in their serum, collected clinical pathological data...
Selecting suitable feed types and understanding the gastrointestinal digestive mechanism are helpful for growth health of calves in intensive dairy farming. However, effects on rumen development changing molecular genetic basis regulatory by using different still unclear. Nine 7-day-old Holstein bull were randomly divided into GF (concentrate), GFF (alfalfa: oat grass = 3:2) TMR (concentrate: alfalfa grass: water 0.30:0.12:0.08:0.50) diet experiment groups. Rumen tissue serum samples...
Abstract: Pyroptosis is a recently discovered type of lytic-programmed cell necrosis. The process involves cells assembling an inflammasome and cleaving gasdermin (GSDM) to trigger the release pro-inflammatory cytokines that eventually induce inflammatory death. Diabetic nephropathy (DN) microvascular complication diabetes mellitus, which leads end-stage renal disease. Podocyte damage or loss important feature diabetic kidney injury. involvement in podocyte injury closely associated with DN...
Abstract Background The significance of S100A8/A9 and S100A12 in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) has not been clarified. This study was dedicated to exploring the potential pathogenic roles patients with myeloperoxidase (MPO)-ANCA-positive vasculitis. Methods Serum urine concentrations forty-two AAV were evaluated. influence on chemotaxis, apoptosis, release IL-1β, complement activation, respiratory burst, as well neutrophil extracellular traps (NETs)...
Abstract Background Photoperiod is an important environmental cue interacting with circadian clock pathway to optimize the local adaption and yield of crops. Quinoa ( Chenopodium quinoa ) in family Amaranthaceae has been known as superfood due nutritious elements. As was originated from low-latitude Andes, most accessions are short-day type. Short-day type usually displays altered growth status when introduced into higher latitude regions. Thus, deciphering photoperiodic regulation on will...
To identify the clinical characteristics, histopathological features, and prognosis of kidney disease in a large cohort elderly patients from Northeast China.We retrospectively analyzed renal spectrum 7,122 who underwent biopsies at Second Hospital Jilin University 2006 to 2020. Patients were grouped according age: below 60 years (non-elderly group, n = 5923) least (elderly 1199). The pathological characteristics biopsy groups using t-test chi-square test.Compared with non-elderly group had...
In domestic mammals, cold stress decreases the survival rate of newborns and increases cost management. Brown adipose tissue (BAT) is main thermogenic organ for cubs, well-developed fetal BAT (FBAT) beneficial to maintain core temperatures during first several days life. However, our knowledge epigenetic mechanisms early development FBAT remains largely unknown. Rabbits (Oryctolagus cuniculus) are economically important animals. this study, a histological analysis shows that content,...
<em>Resistant Starch (RS) has various functions in controlling the Glycemic Index (GI), lowering concentration of cholesterol and triglycerides, inhibiting fat accumulation, preventing colonic cancer, reducing gall stone formation, maintaining intestinal tract healthy enhancing absorption minerals. Elevated RS food is an important effective approach for public health. also material industries. In this paper, producing technologies resistant starch from buckwheat were investigated. The...
To compare the pregnancy outcomes of frozen-thawed embryo transfer (FET) cycles among women with repeated implantation failure (RIF) treated various endometrial preparation protocols.A total 605 RIF were retrospectively recruited between January 2017 and December 2020 from Northern Theater General Hospital. Patients divided into natural cycles, hormone replacement therapy (HRT) depot gonadotropin-releasing (GnRH) agonist-HRT, scratching (ES) plus GnRH agonist-HRT. The primary endpoint was...
To determine the risk factors of occurrence and treatment failure peritoneal dialysis associatedperitonitis (PDAP) due to polymicrobial infections.We retrospectively collected clinical data patients with PDAP from (PD) centers in 4 general hospitals Jilin Province 2013 2019. The were divided, according results dialysate culture, into group control for comparison data, outcomes, long-term prognosis. independent explored using multivariate regression analysis.We recruited a total 625 PD...