A5020010918- Optical Wireless Communication Technologies
- Drug Transport and Resistance Mechanisms
- Natural product bioactivities and synthesis
- Cancer, Hypoxia, and Metabolism
- Nanoplatforms for cancer theranostics
- MicroRNA in disease regulation
- Circular RNAs in diseases
- SARS-CoV-2 and COVID-19 Research
- Cancer-related molecular mechanisms research
- Orbital Angular Momentum in Optics
- Pharmacological Effects and Toxicity Studies
- Renal Transplantation Outcomes and Treatments
- Radioactive element chemistry and processing
- Advanced Optical Sensing Technologies
- RNA modifications and cancer
- Cancer Treatment and Pharmacology
- HIV/AIDS drug development and treatment
- Bioactive Natural Diterpenoids Research
- Curcumin's Biomedical Applications
- Epigenetics and DNA Methylation
- Advanced Proteomics Techniques and Applications
- Metal-Catalyzed Oxygenation Mechanisms
- Acute Myocardial Infarction Research
- Machine Learning in Bioinformatics
- Advanced Drug Delivery Systems
Changchun University of Science and Technology
2010-2025
Anhui Medical University
2024-2025
Zhejiang Medical and Health Group Hangzhou Hospital
2025
Zhejiang University
2015-2024
Second Affiliated Hospital of Jilin University
2021-2024
Lishui University
2023-2024
Capital Medical University
2022-2024
Chinese Academy of Sciences
2024
Nanjing University of Chinese Medicine
2021-2024
Jiangsu Province Hospital
2023-2024
Immunogenic cell death (ICD)-associated immunogenicity can be evoked through reactive oxygen species (ROS) produced via endoplasmic reticulum (ER) stress. In this study, we generate a double ER-targeting strategy to realize photodynamic therapy (PDT) photothermal (PTT) immunotherapy. This nanosystem consists of pardaxin (FAL) peptides modified-, indocyanine green (ICG) conjugated- hollow gold nanospheres (FAL-ICG-HAuNS), together with an oxygen-delivering hemoglobin (Hb) liposome (FAL-Hb...
The etiology of schizophrenia (SCZ) is regarded as one the most fundamental puzzles in current medical research, and its diagnosis limited by lack objective molecular criteria. Although plenty studies were conducted, SCZ gene signatures identified these independent are found highly inconsistent. As important factors contributing to this inconsistency, feature selection methods used currently do not fully consider reproducibility among discovered from different datasets. Therefore, it crucial...
Abstract Background Recently, plasma miRNAs have been reported as biomarkers for various diseases. However, the knowledge on association of with ischemic stroke is still lacking. In this study, we investigated whether concentrations miR-30a, miR-126 and let-7b may be in humans. Methods One hundred ninety seven patients were recruited their blood samples collected at 24 h, 1 week, 4 weeks, weeks 48 after symptoms onset, fifty healthy volunteers selected control. Levels miRNA quantified by...
The type IV bacterial secretion system (SS) is reported to be one of the most ubiquitous SSs in nature and can induce serious conditions by secreting SS effectors (T4SEs) into host cells. Recent studies mainly focus on annotating new T4SE from huge amount sequencing data, various computational tools are therefore developed accelerate annotation. However, these as heavily dependent selected methods their annotation performance need further enhanced. Herein, a convolution neural network (CNN)...
Both photothermal therapy (PTT) and photodynamic (PDT) are phototherapeutic approaches, which have been widely investigated for cancer mediated by an external light source. Here, a nanosystem presenting the synchronous PTT PDT effect realized through one-step near-infrared (NIR) irradiation is reported. This system was fabricated conjugating indocyanine green (ICG) on hollow gold nanospheres (HAuNS) using branched-polyethylenimine (PEI, MW = 10 kDa) as optimal linker, provided high ICG...
Histone deacetylase 6 (HDAC6) plays a key role in variety of neurological disorders, which makes it attractive drug target for the treatment Alzheimer's disease, Parkinson's and memory/learning impairment. The selectivity HDAC6 inhibitors (sHDAC6Is) are widely considered to be susceptible sizes their Cap group physicochemical properties linker or zinc-binding group, discovery new sHDAC6Is extremely difficult. With distinct between Trichostatin A (TSA) enantiomers, chirality residing...
It remains a formidable challenge to fabricate degradable plastics that are recyclable, easy for processing and safe use in seawater. In this study, poly(vinyl alcohol) (PVA)-based supramolecular capable of degrading soil recycling under mild conditions fabricated by grafting 4-carboxybenzaldehyde (CBA) onto PVA chains (hereafter denoted as PVA-CBA). The PVA-CBA dynamically cross-linked with high density hydrogen bonds hydrogen-bond-cross-linked hydrophobic domains. exhibit yield strength...
As large language models gain traction in the financial sector, they are revolutionizing workflows of professionals. From data analysis and market forecasting to risk assessment customer management, these demonstrate significant potential value. By automating processing tasks, enhance productivity empower professionals derive deeper insights make more precise decisions. This article explores application conversational intelligent reporting systems, leveraging artificial intelligence models,...
The transdermal administration of chemotherapeutic agents is a persistent challenge for tumor treatments. A model anticancer agent, epirubicin (EPI), attached to functionalized superparamagnetic iron-oxide nanoparticles (SPION). covalent modification the SPION results in EPI–SPION, potential drug delivery vector that uses magnetism targeted chemotherapy skin tumors. spherical EPI–SPION composite exhibits excellent magnetic responsiveness with saturation magnetization intensity 77.8 emu g−1....
Photosensitizer, proper laser irradiation, and oxygen are essential components for effective photodynamic therapy (PDT) in clinical cancer therapy. However, native hypoxic tumoral microenvironment is a major barrier hindering reactions vivo. Thus, we have prepared biocompatible liposomes by loading complexes of oxygen-carrier (hemoglobin, Hb) photosensitizer (indocyanine green, ICG) enhanced PDT against tumor. Ideal donor Hb, which an oxygen-carried protein red blood cells, makes such...
A ratiometric two-photon fluorescent probe for HClO was deliberately constructed to reveal the generation of in alcohol-induced liver injury.
Abstract Background Effective antiviral drugs for COVID-19 are still lacking. This study aims to evaluate the clinical outcomes and plasma concentrations of baloxavir marboxil favipiravir in patients. Methods Favipiravir acid were evaluated their activity against SARS-CoV-2 vitro before trial initiation. We conducted an exploratory with 3 arms involving hospitalized adult patients COVID-19. Patients randomized assigned a 1:1:1 ratio into group, control group. The primary outcome was...
Microbial community (MC) has great impact on mediating complex disease indications, biogeochemical cycling and agricultural productivities, which makes metaproteomics powerful technique for quantifying diverse dynamic composition of proteins or peptides. The key role biostatistical strategies in MC study is reported to be underestimated, especially the appropriate application feature selection method (FSM) largely ignored. Although extensive efforts have been devoted assessing performance...
Anti-programmed cell death protein 1 (PD-1) therapy has shown promising efficacy in hepatocellular carcinoma (HCC), but its response rates advanced HCC are lower than 20%. A critical reason for this is the imbalance between CD8
The coronavirus disease 2019 (COVID-19) pandemic underlines the urgent need for effective mRNA vaccines. However, current understanding of immunological outcomes vaccines formulated under different nanoplatforms is insufficient. Here, severe acute respiratory syndrome 2 receptor binding domain delivered via lipid nanoparticle (LNP), cationic nanoemulsion (CNE), and liposome (Lipo) was constructed. Results demonstrated that structural biochemical characteristics nanoparticles shaped their...
IntroductionRoxadustat, an oral hypoxia-inducible factor prolyl hydroxylase inhibitor, can stimulate erythropoiesis. Our objective was to evaluate the efficacy and safety of roxadustat for treatment post-transplantation anemia (PTA).MethodsA total 150 adult renal transplant recipients who underwent PTA were randomized either experimental group or control group. During 12-week phase, iron treatment, only. The phase followed by a extended period in which all participants prescribed according...
Abstract RNF214 is an understudied ubiquitin ligase with little knowledge of its biological functions or protein substrates. Here we show that the TEAD transcription factors in Hippo pathway are substrates RNF214. induces non-proteolytic ubiquitylation at a conserved lysine residue TEADs, enhances interactions between TEADs and YAP, promotes transactivation downstream genes signaling. Moreover, YAP TAZ could bind polyubiquitin chains, implying underlying mechanisms by which regulates...