A5079640739- Genomic variations and chromosomal abnormalities
- Prenatal Screening and Diagnostics
- Gestational Trophoblastic Disease Studies
- Advanced Vision and Imaging
- Semiconductor materials and devices
- Silicon Carbide Semiconductor Technologies
- Image Processing Techniques and Applications
- Histone Deacetylase Inhibitors Research
- CCD and CMOS Imaging Sensors
- Peptidase Inhibition and Analysis
- Congenital Diaphragmatic Hernia Studies
- Ectopic Pregnancy Diagnosis and Management
- Cytomegalovirus and herpesvirus research
- Cholinesterase and Neurodegenerative Diseases
- Diamond and Carbon-based Materials Research
- Spine and Intervertebral Disc Pathology
- Uterine Myomas and Treatments
- Advancements in Semiconductor Devices and Circuit Design
- Chemical Synthesis and Analysis
- Optimal Power Flow Distribution
- Intensive Care Unit Cognitive Disorders
- Power System Reliability and Maintenance
- Cardiac, Anesthesia and Surgical Outcomes
- Chromosomal and Genetic Variations
- Soft tissue tumor case studies
Chongqing University of Posts and Telecommunications
2024
Zhejiang University
2000-2022
First Affiliated Hospital Zhejiang University
2022
Zhejiang Shuren University
2020
Lanzhou University
2020
Women's Hospital, School of Medicine, Zhejiang University
2019
Histone deacetylase 6 (HDAC6) plays a key role in variety of neurological disorders, which makes it attractive drug target for the treatment Alzheimer's disease, Parkinson's and memory/learning impairment. The selectivity HDAC6 inhibitors (sHDAC6Is) are widely considered to be susceptible sizes their Cap group physicochemical properties linker or zinc-binding group, discovery new sHDAC6Is extremely difficult. With distinct between Trichostatin A (TSA) enantiomers, chirality residing...
Abstract The abnormal expression of histone deacetylase 8 (HDAC8) has been reported to associate with various cancer entities (colon, breast cancer, pancreas, etc.) as well parasitic diseases, making HDAC8 gradually develop into an attractive and potential therapeutic target. Among the design strategies selective inhibitors (modification Cap, Linker, or zinc binding group regions), optimization Cap region aroused great interest among researchers. However, detailed information underlying how...
Extensive studies have revealed that cognitive processing was impaired after anesthesia and surgery, particularly for the elderly patients. However, most of existing focused on general deficits (e.g., delayed neuro-cognitive recovery POCD). Although diagnosis social abilities has been used in various clinical fields, few investigated potential deficit cognition surgery. The current study examined whether there any dysfunction We achieved this by taking biological motion as stimuli interest,...
To investigate the effect of accumulated spinal axial biomechanical loading on mice lumbar disc and feasibility applying this method to establish a intervertebral degeneration model using custom-made hot plate cage. In previous studies, we observed that motion pattern was greatly similar humans when they were standing jumping their lower limbs. There is little data demonstrate whether or not could induce in vivo.Twenty-four 0-week-old randomly divided into 1-month 3-month groups, control...
Purpose: High-risk gestational trophoblastic neoplasia (GTN) can lead to fatal complications; however, few reports have assessed emergency surgery as a treatment option for such complications. Thus, this study aimed analyze the clinical features and prognosis of patients with GTN who underwent surgery. Patients Methods: Thirteen high-risk or ultra-high-risk complications in First Affiliated Hospital Zhejiang University, School Medicine from 2013 2020 were analyzed, their medical records...
Abstract Resilience evaluation plays a critical role in the decarbonized development of modern power distribution systems since it objectively assesses how system performs face stochastic renewable generation, increasing load demand, and promising to cut carbon emissions. This study proposed comprehensive resilience method for regional systems. The comprises three sub-groups: performance, economy, connections. To improve objectivity method, weighting factors are calculated based on Analytic...
Presents corrections to the paper, (Corrections "Diamond-on-Si IGBT With Ultrahigh Breakdown Voltage and On-State Current").
The aim of this study was to investigate the application amniotic fluid cell lines with chromosomal abnormalities in external quality assessment (EQA) prenatal karyotype analysis. Simian virus 40 large T antigen (SV40LT) gene transfected into cells 46,XY,t(15;17)(q11;q11) and 46,XY by liposome transfection. Control were produced mixing above two ratios 1:19, 1:1 9:1, respectively. then frozen at −30 °C, mailed between laboratories, prepared for chromosome analysis, photographed karyotype,...
Abstract Background The goal of this study was to determine whether Levey-Jennings charts, which are widely used in clinical laboratories, can be create standardized internal quality controls (IQCs) for prenatal molecular diagnosis. Methods Aneuploid amniocyte lines with trisomy 13, 21, and 18, 47,XXY were established by transfection SV40LTag-pcDNA3.1(−)and combined at different ratios generate aneuploidy chimeric quality-control cell mixtures A H. These cells then calculate the $$...
Background The shortage of quality-control materials caused by non-renewable utilization rare disease samples is the key factor to limit quality control prenatal molecular diagnosis. This study aimed prepare aneuploid amniocyte lines for development cells fluorescence in situ hybridization (FISH)-mediated detection aneuploidy. Methods Recombinant SV40LTag-pcDNA3.1(-) vectors were transfected into 47,XY,+18 amniotic fluid with use liposomes. After culturing, these mixed primary amniocytes...
Real-Time Image Processing is the key work in robot vision. With limitation of hardware technique, many algorithm-oriented firmware systems were designed past. But their architectures not flexible enough to achieve a multi-algorithm development system. Because rapid microelectronics high performance DSP chips and density FPGA have come life, this makes it possible construct more architecture real-time image processing In paper, Double General System (DDGIPS) concerned. We try two-DSP-based...
Real-Time Image Processing is the key work in robot vision. With limitation of hardware technique, many algorithm-oriented firmware systems were designed past. But their architectures not flexible enough to achieve a multi- algorithm development system. Because rapid microelectronics high performance DSP chips and density FPGA have come life, this makes it possible construct more architecture real-time image processing In paper, Double General System (DDGIPS) concerned. We try two-DSP-based...