A5050038706- Bone and Joint Diseases
- Osteoarthritis Treatment and Mechanisms
- Orthopaedic implants and arthroplasty
- Orthopedic Infections and Treatments
- Total Knee Arthroplasty Outcomes
- Bone health and treatments
- Hip disorders and treatments
- Hemophilia Treatment and Research
- Bone Metabolism and Diseases
- Spine and Intervertebral Disc Pathology
- Hip and Femur Fractures
- Bone fractures and treatments
- Mesenchymal stem cell research
- Lower Extremity Biomechanics and Pathologies
- Rheumatoid Arthritis Research and Therapies
- Shoulder Injury and Treatment
- Orthopedic Surgery and Rehabilitation
- Inflammatory mediators and NSAID effects
- Chronic Myeloid Leukemia Treatments
- Pelvic and Acetabular Injuries
- Diabetic Foot Ulcer Assessment and Management
- Bone health and osteoporosis research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Pharmacological Effects of Natural Compounds
Zhejiang Chinese Medical University
2016-2025
Zhejiang Hospital
2009-2025
Affiliated Hospital of Liaoning University of Traditional Chinese Medicine
2022
Zhejiang Provincial Hospital of TCM
2012-2021
Zhejiang University
2009-2021
Hangzhou Hospital of Traditional Chinese Medicine
2009-2020
Jiangsu Province Hospital
2020
National Institute of Traumatology & Orthopaedic Rehabilitation
2018-2020
Nanjing Medical University
2020
Sir Charles Gairdner Hospital
2011
Abstract Background Lumbar disc herniation (LDH), as one of the most common causes lower back pain, imposes a heavy economic burden on patients and society. Conservative management is first‐line choice for majority LDH patients. Traditional Chinese medicine (TCM) an important part conservative treatment has attracted more international attention. Study design Evidence‐based guideline. Methods We formed guideline panel multidisciplinary experts. The clinical questions were identified basis...
Repair of the posterior soft tissue via a posterolateral approach following total hip arthroplasty has been reported to mitigate risk dislocation. The joint capsule serves as primary protective barrier, and while previous techniques for closure have predominantly complex, we present novel, simplified technique closure. A 215 patients who underwent THA at our hospital from May 2018 December 2022 were retrospectively enrolled in this study: 111 had their capsules sutured using traditional...
To investigate the expression and significance of MMP-3 in synovium knee joint at different stage osteoarthritis (OA) patients.Knee synovial tissue were collected 90 OA patients (the group). Patients group was divided into 3 subgroups: grade I subgroup (n=30), II III; (n=30). Thirty served as control group. Immunohistochemical assay used to detect protein tissue.MMP-3 detected all tissue. The significantly higher that normal (P<0.05), mainly located cytoplasm. There significant difference...
Abstract Aberrant mechanical factor is one of the etiologies intervertebral disc (IVD) degeneration (IVDD). However, exact molecular mechanism spinal loading stress-induced IVDD has yet to be elucidated due a lack an ideal and stable animal model. The present study aimed establish mouse model evaluated effect aberrant on pathogenesis IVDD. Eight-week-old male mice were treated with lumbar spine instability (LSI) surgery induce progression was by μCT Safranin O/Fast green staining analysis....
Abstract α‐Solanine has been shown to exhibit anti‐inflammatory and anti‐tumour properties; however, its efficacy in treating osteoarthritis (OA) remains ambiguous. The study aimed evaluate the therapeutic effects of α‐solanine on OA development a mouse model. mice were subjected varying concentrations α‐solanine, various assessments implemented assess progression. We found that significantly reduced osteophyte formation, subchondral sclerosis OARSI score. And it decreased proteoglycan loss...
ABSTRACT The objective of this study was to determine the benefits combination treatment with mechanical support and targeted intra-arterial infusion peripheral blood stem cells (PBSCs) mobilized by granulocyte–colony stimulating factor (G-CSF) via medial circumflex femoral artery on progression osteonecrosis head (ONFH). Fifty-five patients (89 hips) early intermediate stage ONFH were recruited randomly assigned or (control group). All hips received (porous tantalum rod implantation). Then,...
Green tea, the fresh leaves of Camellia sinensis, is not only a health-promoting beverage but also traditional Chinese medicine used for prevention or treatment cancer, such as lung cancer. Theabrownin (TB) main fraction responsible medicinal effects green whether it possesses anti-cancer effect unknown yet. This study aimed to determine in vitro and vivo anti-lung cancer TB explore underlying molecular mechanism, by using A549 cell line Lewis carcinoma-bearing mice. In cellular experiment,...
Abstract Background The short-term safety and efficacy of stromal vascular fraction (SVF) in treating knee osteoarthritis (KOA) have been extensively studied but the mid-term long-term prognoses remain unknown. Methods 126 KOA patients were recruited randomly assigned to SVF group hyaluronic acid (HA) (control group). scores visual analogue scale (VAS) Western Ontario McMaster University Osteoarthritis Index (WOMAC) assessed compared between two groups 1, 2, 3, 5 years after treatment....
Background: Osteoarthritis (OA) is the most common joint disorder, lacking disease-modifying treatments. Adipose-derived mesenchymal stem cells (ADSCs) are adult multipotent stromal obtained from fat tissue, which holds great potential in treating OA. This study aimed to evaluate anti-OA efficacy of ADSCs preclinical and clinical facets explore underlying mechanism action. Methods:In vivo, a single dose 5 × 105 was injected into knee joints monoiodoacetate-induced OA rat model. The levels...
Abstract Osteoarthritis (OA) is an entire joint disease with pathological alteration in both articular cartilage and subchondral bone. It has been recognized recently the association between metabolic syndrome OA, particularly glucose metabolism regulation of homeostasis integrity. Whereas role bone sclerosis remains largely unknown during pathogenesis OA. Consistent common OA features, we observed abnormal remodeling human joints murine as reflected by hyperactive resorption overall...