A5102900275- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Pancreatic and Hepatic Oncology Research
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Protein Degradation and Inhibitors
- RNA modifications and cancer
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Natural product bioactivities and synthesis
- Ginseng Biological Effects and Applications
- Light effects on plants
- Cancer-related gene regulation
- Cancer Immunotherapy and Biomarkers
- Extracellular vesicles in disease
- Adenosine and Purinergic Signaling
- Ubiquitin and proteasome pathways
- Genomics and Chromatin Dynamics
- Hippo pathway signaling and YAP/TAZ
- Immunotherapy and Immune Responses
- PARP inhibition in cancer therapy
- Histone Deacetylase Inhibitors Research
- Neuroblastoma Research and Treatments
Renji Hospital
2021-2025
Shanghai Cancer Institute
2021-2025
Shanghai Jiao Tong University
2021-2025
Sichuan University
2020-2025
State Key Laboratory of Biotherapy
2022-2025
Ministry of Education of the People's Republic of China
2008-2025
Northwest University
2008-2025
Xi'an Botanical Garden of Shaanxi Province
2025
Institute of Botany
2025
Nanjing Medical University
2025
The roles of RNA 5-methylcytosine (RNA:m5C) and RNA:m5C methyltransferases (RCMTs) in lineage-associated chromatin organization drug response/resistance are unclear. Here we demonstrate that the RCMTs, namely NSUN3 DNMT2, directly bind hnRNPK, a conserved RNA-binding protein. hnRNPK interacts with lineage-determining transcription factors (TFs), GATA1 SPI1/PU.1, CDK9/P-TEFb to recruit RNA-polymerase-II at nascent RNA, leading formation 5-Azacitidine (5-AZA)-sensitive structure. In contrast,...
Cellular-mesenchymal epithelial transition factor (c-Met) is an attractive target for treating multiple cancers. Despite plentiful c-Met inhibitors have been developed, some issues, including the acquired drug resistance to inhibitors, emerged hamper their application in clinical treatment. Degradation of offers opportunity solve these issues. In this study, we developed a series degraders, and optimal compound 22b can efficiently degrade with DC50 value 0.59 nM EBC-1 cells. Mechanistic...
The development of the embryonic vascular system into a highly ordered network requires precise control over migration and branching endothelial cells (ECs). We have previously identified angiomotin (Amot) as receptor for angiogenesis inhibitor angiostatin. Furthermore, DNA vaccination targeting Amot inhibits tumor growth. However, little is known regarding role in physiological angiogenesis. therefore investigated neovascularization during zebrafish mouse embryogenesis. Here we report that...
Abstract Amplification of the MYCN gene in human neuroblastoma predicts poor prognosis and resistance to therapy. We previously showed that ‐amplified cells constantly require large amounts glutamine support their unabated growth. However, identity regulation transporter(s) capture clinical significance diagnosis remain largely unknown. Here, we performed a systemic influx analysis identified predominantly rely on activation ASCT2 (solute carrier family 1 member 5, SLC1A5 ) maintain...
Abstract Background Circular RNAs (circRNAs) are differentially expressed between normal and cancerous tissues, contributing to tumor initiation progression. However, comprehensive landscape of dysregulated circRNAs across cancer types remains unclear. Methods In this study, we conducted Ribo-Zero transcriptome sequencing on tissues their adjacent samples including glioblastoma, esophageal squamous cell carcinoma, lung adenocarcinoma, thyroid cancer, colorectal gastric hepatocellular...
Pancreatic ductal adenocarcinoma (PDAC) is a malignant tumor with an extremely poor prognosis. Effective targets for anticancer therapy confirmed in PDAC are limited. However, the characteristics of genomics have not been fully elucidated large-scale patients from China.We collected both blood and tissue samples 1080 Chinese pancreatic cancer retrospectively investigated genomic landscape using next-generation sequencing (NGS).We found recurrent somatic mutations KRAS (83.2%), TP53 (70.6%),...
Distant metastasis is a major contributor to cancer-related mortality. However, the role of circRNAs in this process remains unclear. Herein, we profiled circRNA expression cohort 68 colorectal carcinoma (CRC) primary tumors and their paired liver metastatic lesions. By overlapping with TGFβ-responsive circRNAs, circNEIL3 (hsa_circ_0001460) was identified as TGFβ-repressive metastasis-related circRNA. Functionally, effectively inhibited tumor both vivo models various cancer types....
Our previous research defined a novel metabolic cancer associated fibroblasts subset (meCAFs) enriched in loose-type pancreatic ductal adenocarcinoma (PDAC) and related to CD8+ T cells accumulation. Consistently, the abundance of meCAFs was with poor prognosis but better immunotherapy responses PDAC patients. However, characteristic its cross-talk remain be elucidated. In this study, we identified PLA2G2A as marker meCAFs. particular, PLA2G2A+ positively accumulation total negatively...
Metastasis is the leading cause of cancer-related death, where TGFβ-induced epithelial-mesenchymal transition (EMT) process confers on cancer cells increased metastatic potential. However, involvement circRNAs in this still obscure. Here, we identify a circRNA called circITGB6 as an indispensable factor during TGFβ-mediated EMT process. significantly upregulated samples and its higher abundance closely correlated to worse prognosis colorectal (CRC) patients. Through gain- loss-of-function...
Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is an oncogenic membrane protein in several malignancies and has been considered attractive target for the treatment of human cancers. In this study, structure-based virtual screening structure optimization were conducted to identify novel ROR1 inhibitors. Based on hit compound 2, 45 inhibitors designed synthesized, detailed structure–activity relationship was investigated. Representative 19h potently binds with a KD value 0.10 μM,...
Cancer stem cells (CSCs) are highly proliferative and tumorigenic, which contributes to chemotherapy resistance tumor occurrence. CSCs specific therapy may achieve excellent therapeutic effects, especially the drug-resistant tumors. In this study, we developed a kind of targeting nanoparticle system based on cationic albumin functionalized with hyaluronic acid (HA) target CD44 overexpressed CSCs. All-trans-retinoic (ATRA) was encapsulated in nanoparticles ultrahigh encapsulation efficiency...
Abstract Aberrant mechanical factor is one of the etiologies intervertebral disc (IVD) degeneration (IVDD). However, exact molecular mechanism spinal loading stress-induced IVDD has yet to be elucidated due a lack an ideal and stable animal model. The present study aimed establish mouse model evaluated effect aberrant on pathogenesis IVDD. Eight-week-old male mice were treated with lumbar spine instability (LSI) surgery induce progression was by μCT Safranin O/Fast green staining analysis....
A co-loaded drug delivery system based on ascorbyl palmitate that can transport various functional drugs to their targets within a tumor represents an attractive strategy for increasing the efficiency of anticancer treatment. In this study, we developed dual encapsulate (AP) and paclitaxel (PTX) synergistic cancer therapy. AP, which is vitamin C derivative, PTX were incorporated into solid lipid nanoparticles (AP/PTX-SLNs), used treat murine B16F10 melanoma had metastasized lungs mice. These...
To date, a growing body of evidence suggests that unfolded protein response (UPR) sensors play vital role in carcinogenesis. However, it remains unclear whether they are involved pancreatic ductal adenocarcinoma (PDAC) and how relate to clinical outcomes. This study aims investigate the biological function mechanism novel UPR sensor, CREB3L1 works PDAC further evaluate its application prospect. We tested signaling including Thapsigargin-treated cells. Subsequently, we defined expression...
Hepatocellular carcinoma (HCC) is a major cause of cancer-related deaths globally, and the need for effective systemic therapies HCC urgent. Our previous work reveals that Pin1 potential anti-HCC target, which regulates miRNA biogenesis identifies API-1 as novel inhibitor to suppresses HCC. However, great demand in therapy well limited chemical stability pharmacokinetic feature motivated us find improved inhibitors. Herein, we designed synthesized diverse 6-O-benzylguanine derivatives...
Abstract Members of the genus Juglans (walnuts, family Juglandaceae) are typical Tertiary relict tree species. They widely distributed in China and well known for their edible nuts high‐quality wood. The genetic structure historical gene flow patterns Chinese still need to be resolved. Here, we collected samples from a total 2242 trees 142 populations three walnut species ( regia L., sigillata Dode, mandshurica Maxim.) hybrid taxon × hopeiensis . These were throughout China. We analyzed...
Human Immunodeficiency Virus (HIV) is one of the most prevalent viruses, causing significant immune depletion in affected individuals. Current treatments can control HIV and prolong patients' lives, but new challenges have emerged. Increasing incidence cancers occur patients. Esophageal squamous cell carcinoma (ESCC) common observed However, spatial cellular characteristics HIV-related ESCC not been explored, differences between HIV-ESCC typical remain unclear. We performed transcriptome...