A5019453814- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Neuroendocrine Tumor Research Advances
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Genomics and Diagnostics
- Cancer, Hypoxia, and Metabolism
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Liver Disease and Transplantation
- Cancer Immunotherapy and Biomarkers
- Phagocytosis and Immune Regulation
- Immune cells in cancer
- Cancer Cells and Metastasis
- Organ Transplantation Techniques and Outcomes
- MicroRNA in disease regulation
- Renal cell carcinoma treatment
- Lung Cancer Research Studies
- Caveolin-1 and cellular processes
- Cancer, Stress, Anesthesia, and Immune Response
- Angiogenesis and VEGF in Cancer
- Pancreatic function and diabetes
- Liver Disease Diagnosis and Treatment
- Gallbladder and Bile Duct Disorders
Shanghai Jiao Tong University
2016-2025
Renji Hospital
2015-2024
Shanghai Cancer Institute
2022-2024
Xian Yang Central Hospital
2021-2024
Inner Mongolia University
2018-2024
State Key Laboratory of Oncogene and Related Genes
2020-2023
First Affiliated Hospital of Xi'an Jiaotong University
2023
Xi'an Jiaotong University
2023
Jiangmen Central Hospital
2023
XinHua Hospital
2018
The current pathological and molecular classification of pancreatic ductal adenocarcinoma (PDAC) provides limited guidance for treatment options, especially immunotherapy. Cancer-associated fibroblasts (CAFs) are major players desmoplastic stroma in PDAC, modulating tumor progression therapeutic response. Using single-cell RNA sequencing, we explored the intertumoral heterogeneity among PDAC patients with different degrees desmoplasia. We found substantial CAFs, cancer cells, immune cells...
Background and aims Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-related death worldwide. Neurotransmitter-initiated signalling pathway profoundly implicated in tumour initiation progression. Here, we investigated whether dysregulated neurotransmitter receptors play role during pancreatic tumourigenesis. Methods The Cancer Genome Atlas Gene Expression Omnibus datasets were used to identify differentially expressed receptors. expression pattern gamma-aminobutyric acid...
Abstract Perineural invasion is a common feature of pancreatic ductal adenocarcinoma (PDAC). Here, we investigated the effect perineural on microenvironment and how this affects PDAC progression. Transcriptome expression profiles tissues with different status were compared, intratumoral T-cell density levels neurotransmitters in these assessed. was associated impaired immune responses characterized by decreased CD8+ T Th1 cells, increased Th2 cells. Acetylcholine elevated severe invasion....
Extensive research has reported that the tumor microenvironment components play crucial roles in progression. Thus, blocking supports of is a promising approach to prevent cancer We aimed determine whether extracellular ATP-P2RY2 axis could be potential therapeutic for PDAC treatment.Expression P2RY2 was determined 264 human samples and correlated patient survival. inhibited cell lines by antagonist shRNA, respectively, viability, clonogenicity, glycolysis were determined. RNA sequencing...
Invasion and metastasis are the distinct biologic characteristics of cancer, resulting in an exceptionally low 5-year survival rate pancreatic ductal adenocarcinoma (PDAC). Understanding detail mechanisms underlying PDAC is critical for prevention effective interventions. Long non-coding RNAs (lncRNAs) have been documented as having a role cancer development progression. We examined expression levels lncRNA ENST00000480739 osteosarcoma amplified-9 (OS-9) mRNA cohort 35 patients. Cell...
Abstract Chronic inflammation is a feature of pancreatic cancer, but little known about how immune cells or cell–related signals affect cancer stemness and development. Our previous work showed that IL22/IL22RA1 plays vital role in acute chronic pancreatitis progression by mediating cross-talk between acinar stellate cells, respectively. Here, we find IL22RA1 highly heterogeneously expressed with high expression associated poor prognosis patients cancer. The IL22RA1hi population from...
Abstract The immunosuppressive microenvironment that is shaped by hepatic metastatic pancreatic ductal adenocarcinoma (PDAC) essential for tumor cell evasion of immune destruction. Neutrophils are important components the and exhibit heterogeneity. However, specific phenotypes, functions regulatory mechanisms neutrophils in PDAC liver metastases remain unknown. Here, we show a subset P2RX1-negative accumulate clinical murine metastases. RNA sequencing metastasis-infiltrated P2RX1-deficient...
BackgroundPancreatic cancer (PC) is one of the most lethal solid malignancies in world due to its excessive cell proliferation and aggressive metastatic features. Emerging evidences revealed importance posttranscriptional modifications RNAs PC progression. However, knowledge about 5-methylcytosine (m5C) RNA modification still extremely limited. In this study, we attempted explore expression changes clinical significances 12 known m5C-related genes among patients.MethodsA total 362 normal 382...
Rationale: Endoplasmic reticulum oxidoreductase 1 alpha (ERO1L) is an endoplasmic (ER) luminal glycoprotein that has a role in the formation of disulfide bonds secreted proteins and membrane proteins. Emerging data identify ERO1L as tumor promoter wide spectrum human malignancies. However, its molecular basis oncogenic activities remains largely unknown. Methods: Pan-cancer analysis was performed to determine expression profile prognostic value cancers. The mechanism by which promotes growth...
Pancreatic ductal adenocarcinoma (PDAC) is a malignant tumor with an extremely poor prognosis. Effective targets for anticancer therapy confirmed in PDAC are limited. However, the characteristics of genomics have not been fully elucidated large-scale patients from China.We collected both blood and tissue samples 1080 Chinese pancreatic cancer retrospectively investigated genomic landscape using next-generation sequencing (NGS).We found recurrent somatic mutations KRAS (83.2%), TP53 (70.6%),...
Objective SETD2, the sole histone H3K36 trimethyltransferase, is frequently mutated or deleted in human cancer, including pancreatic ductal adenocarcinoma (PDAC). However, whether SETD2/H3K36me3 alteration results PDAC remains largely unknown. Design TCGA(PAAD) public database and tissue array with staining were used to investigate clinical relevance of SETD2 PDAC. Furthermore, define role carcinogenesis PDAC, we crossed conditional Setd2 knockout mice ( Pdx cre flox/flox ) together Kras...
Abstract: The application of Fe 3 O 4 nanoparticles (NPs) has made great progress in the diagnosis disease and drug delivery system for cancer therapy, but relative mechanisms potential toxicity induced by have not kept pace with its development application, which hampered further clinical application. In this article, we used two kinds human hepatoma cell lines, SK-Hep-1 Hep3B, to investigate cytotoxic effects involved mechanisms small NPs different diameters (6 nm, 9 14 nm). Results...
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive and lethal malignancies. Long non-coding RNAs (lncRNAs) are a novel class non-protein-coding transcripts that have been implicated in cancer biogenesis prognosis. By repurposing microarray probes, we herein analysed lncRNA expression profiles two public PDAC datasets identified 34 dysregulated lncRNAs PDAC. In addition, 6 selected was confirmed Ren Ji cohort pancreatic cell lines, their association with 80 patients'...
Abstract Hypoxia and the hypovascular tumor microenvironment are major hallmarks of pancreatic ductal adenocarcinoma (PDAC), in which glycolysis is great importance to survival proliferation. There little research regarding role Nuclear Factor Activated T Cells 5 (NFAT5) relation carcinoma. Here, we explored impact NFAT5 on biological behavior PDAC underlying mechanism. We demonstrated that was highly expressed related poorer prognosis. Knockdown lead impaired proliferation cells caused by...
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers due to its high metastasis rate in liver. However, little known about molecular features hepatic metastases difficulty obtaining fresh tissues and low tumor cellularity.
Abstract Genetic and epigenetic alterations play central roles in shaping the immunosuppressive tumor microenvironment (TME) to evade immune surveillance. The previous study shows that SETD2‐H3K36me3 loss promotes KRAS‐induced pancreatic tumorigenesis. However, little is known about its role remodeling TME evasion. Here, it shown SETD2 deficiency can reprogram neutrophils an phenotype, thereby promoting escape during progression. By comprehensive profiling of intratumoral cells, are...
Pancreatic ductal adenocarcinoma (PDAC) features substantial matrix stiffening and reprogrammed glucose metabolism, particularly the Warburg effect. However, complex interplay between these traits their impact on tumor advancement remains inadequately explored. Here, we integrated clinical, cellular, bioinformatics approaches to explore connection stiffness effect in PDAC, identifying CLIC1 as a key mediator. Elevated expression, induced by through Wnt/β-catenin/TCF4 signaling, signifies...