A5032973528- Cancer-related molecular mechanisms research
- Systemic Lupus Erythematosus Research
- RNA modifications and cancer
- Autoimmune Bullous Skin Diseases
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Immune Cell Function and Interaction
- SARS-CoV-2 and COVID-19 Research
- Cancer Immunotherapy and Biomarkers
- Heat shock proteins research
- Autonomous Vehicle Technology and Safety
- Toxin Mechanisms and Immunotoxins
- Cell death mechanisms and regulation
- Extracellular vesicles in disease
- Traffic control and management
- Galectins and Cancer Biology
- Calpain Protease Function and Regulation
- COVID-19 epidemiological studies
- MicroRNA in disease regulation
- Sphingolipid Metabolism and Signaling
- Immune cells in cancer
- FOXO transcription factor regulation
- Genetic Associations and Epidemiology
- Ginseng Biological Effects and Applications
- interferon and immune responses
Fudan University Shanghai Cancer Center
2022-2024
Shanghai Medical College of Fudan University
2024
Shanghai Jiao Tong University
2020-2023
Fudan University
2023
Chinese University of Hong Kong
2022
Renji Hospital
2020-2022
Shanghai Cancer Institute
2020-2021
State Key Laboratory of Oncogene and Related Genes
2020-2021
Chang'an University
2020
Abstract The immunosuppressive microenvironment that is shaped by hepatic metastatic pancreatic ductal adenocarcinoma (PDAC) essential for tumor cell evasion of immune destruction. Neutrophils are important components the and exhibit heterogeneity. However, specific phenotypes, functions regulatory mechanisms neutrophils in PDAC liver metastases remain unknown. Here, we show a subset P2RX1-negative accumulate clinical murine metastases. RNA sequencing metastasis-infiltrated P2RX1-deficient...
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest malignancies and known for its high resistance low response to treatment. Tumor immune evasion a major stumbling block in designing effective anticancer therapeutic strategies. Karyopherin alpha 2 (KPNA2), member nuclear transporter family, elevated multiple human cancers accelerates carcinogenesis. However, specific role KPNA2 PDAC remains unclear. In this study, we found that expression was significantly upregulated compared...
Purpose Studies have shown a close relationship between gut microbiota (GM) and Alzheimer’s disease (AD). However, the causal them remains unclear. Methods We conducted genome-wide association study (GWAS) using publicly available summary statistics data for GM AD. extracted independent genetic loci significantly associated with relative abundances as instrumental variables based on predefined thresholds ( p < 1*e−5). The inverse variance-weighted (IVW) method was primarily used...
Background: High levels of COP9 signalosome subunit 5 (CSN5) in epithelial ovarian cancer (EOC) are associated with poor prognosis and implicated mediating platinum resistance EOC cells.The underlying mechanisms, however, remained undefined.This study aimed to elucidate the molecular process identify potential therapeutic targets.Methods: RNA-sequencing was used investigate differentially expressed genes between platinum-resistant cells CSN5 knockdown controls.O-GlcNAc proteomics were...
Driver’s intention of the front vehicle plays an important role in automatic emergency braking (AEB) system. If brakes suddenly, there is potential collision risk for following vehicle. Therefore, we propose a driver’s recognition model vehicle, which based on backpropagation (BP) neural network and hidden Markov (HMM). The brake pedal, accelerator speed data are used as input proposed BP-HMM to recognize intention, includes uniform driving, normal braking, braking. According recognized...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers, which lacks effective treatment strategies. There an urgent need for development new strategies PDAC therapy. The genetic and phenotypic heterogeneity cancer cell populations poses further challenges in clinical management PDAC. In this study, we performed single-cell RNA sequencing to characterize tumors from KPC mice. Functional studies analysis showed that cluster 2 cells with highly Hsp90 expression much...
Lenvatinib, an approved first-line regimen, has been widely applied in hepatocellular carcinoma (HCC). However, clinical response towards Lenvatinib was limited, emphasizing the importance of understanding underlying mechanism its resistance. Herein, we employed integrated bioinformatic analysis to identify calpain-2 (CAPN2) as a novel key regulator for resistance HCC, and expression greatly increased both Lenvatinib-resistant HCC cell lines samples. Further vitro vivo experiments indicated...
Accumulating evidence has pointed out that metastasis is the leading cause of death in several malignant tumor, including CRC. During CRC, metastatic capacity closely correlated with reprogrammed energy metabolism. Mitochondrial Pyruvate Carrier 1 (MPC1), as carrier transporting pyruvate into mitochondria, linked glycolysis and TCA cycle, which would affect production. However, specific role MPC1 on tumor CRC remains unexplored. Here, by data mining genes involved metabolism using TCGA...
The SARS-CoV-2 pandemic has imposed substantial health and economic burdens on the societies. COVID-19 vaccination is most effective method of controlling epidemic. This study assessed attitude, willingness, related factors adult patients with rheumatic diseases (RDs) in China towards identified their reasons for being vaccinated. A cross-sectional survey was administered to from July 18 August 18, 2021, using an online questionnaire. Logistic regression analysis performed examine data.We...
<title>Abstract</title> Type I interferon (IFN-I) is essential in the development of Systemic Lupus Erythematosus (SLE) and many other autoimmune diseases. To explore metabolic regulations IFN-I signaling pathway, we conducted a high through-put screening small molecule library identified diosmetin as potent compound for blocking signaling. We showed functioned by preventing alteration cellular phosphatidylethanolamine spatiotemporal dynamics IFNAR2 during activation CYP1B1 was verified...
Abstract Background This study was conducted to investigate the expression patterns and biological roles of urinary long non-coding RNAs (lncRNAs) messenger (mRNAs) in individuals diagnosed with lupus nephritis (LN). Methods The cohort comprised six participants: three systemic erythematosus (SLE) involving LN, SLE without healthy controls (CON). Microarray technology employed analyze mRNAs lncRNAs, thereby exploring alterations overall RNA expression. Functional insights into dysregulated...