A5112637036- Spine and Intervertebral Disc Pathology
- Temporomandibular Joint Disorders
- Knee injuries and reconstruction techniques
- Nutrition and Health in Aging
- Orthodontics and Dentofacial Orthopedics
- Total Knee Arthroplasty Outcomes
- Shoulder Injury and Treatment
- Cancer-related molecular mechanisms research
- Sports injuries and prevention
- Orthopedic Surgery and Rehabilitation
- Cleft Lip and Palate Research
- Tendon Structure and Treatment
- Myofascial pain diagnosis and treatment
- Pharmacological Effects of Natural Compounds
- Erythrocyte Function and Pathophysiology
- Botulinum Toxin and Related Neurological Disorders
- Body Composition Measurement Techniques
- Lower Extremity Biomechanics and Pathologies
- Cytokine Signaling Pathways and Interactions
- Pelvic and Acetabular Injuries
- Estrogen and related hormone effects
- Craniofacial Disorders and Treatments
- Spinal Fractures and Fixation Techniques
- Cervical and Thoracic Myelopathy
- Musculoskeletal pain and rehabilitation
Shanghai Ninth People's Hospital
2017-2025
Shanghai Jiao Tong University
2012-2025
Wenzhou Medical University
2019-2025
Xi'an University of Technology
2024-2025
Fujian Medical University
2024
Shanghai Sixth People's Hospital
2021-2024
Zhejiang University
2022-2024
Sir Run Run Shaw Hospital
2022-2024
Shaoxing People's Hospital
2022-2024
Tongde Hospital of Zhejiang Province
2024
The regulatory mechanism of endometrial carcinoma and the signal transduction pathways involved in hormone action are poorly defined. It has become apparent that G protein-coupled receptor (GPR) 30 mediates non-genomic signaling 17beta-estradiol (E2). Here we show GPR30 is highly expressed cancer tissues cell lines positively regulates proliferation invasion. expression was detected 50 human carcinomas. transcription level significantly higher tissue than normal endometrium (P < 0.05)....
Background: Post-traumatic joint contracture (PTJC) mainly manifests as excessive inflammation leading to capsule fibrosis. Transforming growth factor (TGF)-β1, a key regulator of and fibrosis, can promote fibroblast activation, proliferation, migration, differentiation into myofibroblasts. Platelet-rich plasma (PRP) is considered have strong potential for improving tissue healing regeneration, the ability treat fibrosis remains largely unknown. Methods: In this study, we aimed determine...
Background Posture assessment is an important part of clinical physical examination. Head posture changes should be considered in the measurement craniofacial morphology and hyoid bone position. Objective To compare position neutral head (NHP) forward (FHP) healthy individuals. Methods Forty participants (16 men 24 women) were included this study. Using lateral cephalograms, we assessed craniofacial, craniocervical, positions based on 27 distinct variables. The paired-samples t-test...
Abstract To maximize the utilization of waste laser printed paper fiber (WLPF), WLPF was used as organic reinforcing phase, high‐density polyethylene (HDPE) matrix, vinyltrimethoxysilane (A171) and γ‐methacryloxytrimethoxysilane (KH570) were coupling agents to modify prepare WLPF/HDPE composites via a blending‐injection molding process. The weather resistance properties mechanisms systematically analyzed using scanning electron microscopy, Fourier‐transform infrared spectroscopy (FTIR),...
Rationale: The emergence of catastrophic antiphospholipid syndrome (CAPS) alongside coronavirus disease 2019 (COVID-19) is great concern, because its high mortality and unclear mechanism. This severe disease, characterized by multiple thrombi multisystem disorder, has notably diverse clinical presentations, which complicates diagnosis in practice. Now, we report a rare case CAPS patient with COVID-19. Patient concerns: A 64-year-old who mainly presented pain swelling 2 months ago progressed...
Abstract The vulnerable plaque is a key distinguishing feature of atherosclerotic lesions that can cause acute atherothrombotic vascular disease. This study was designed to explore the effect autophagy on mitochondria‐mediated macrophage apoptosis and plaques. Here, we generated mouse model carotid in ApoE −/− mice. Application mice with rapamycin (an inducer) inhibited necrotic core formation plaques by decreasing apoptosis. However, 3‐methyladenine inhibitor) promoted vulnerability through...
Background: This study aimed to investigate the prevalence rate of adult sarcopenic obesity and discuss its predisposing factors. Methods: A total 14,608 participants including 7521 men 7087 women aged 18-93 years were enrolled in this study. The definition sarcopenia was based on appendicular skeletal muscle mass index (ASMI) standards (≤7.0 kg/m2 for ≤5.7 grams/m2 women). followed percent body fat (PBF) ≥25% ≥35% women. Sarcopenic defined as combination diagnosis. Risk factors onset...
Spinal cord injury (SCI) is a devastating event with limited hope for recovery and represents an enormous public health issue. It crucial to understand the disturbances in metabolic network after SCI identify mechanisms opportunities treatment intervention. Through plasma 1H-nuclear magnetic resonance (NMR) screening, we identified 15 metabolites that made up “Eigen-metabolome” capable of distinguishing rats severe from healthy control rats. Forty enzymes regulated these network. We also...
Joint capsule fibrosis caused by excessive inflammation leading to post-traumatic joint contracture (PTJC). Fibroblasts trigger under the challenge of various proinflammatory cytokines. Macrophage migration inhibitory factor (MIF) is a prominent cytokine involved in inflammation- and fibrosis-associated pathophysiology, we investigated role MIF PTJC.Using rat PTJC model fibroblast model, detected expression posterior capsule. Primary fibroblasts (JFs) were used investigate effects on cell...
The objectives of the study were to evaluate role mitogen-activated protein kinase (MAPK) signaling in normal, hyperplastic, and neoplastic endometrium relation estrogen receptor (ER) status investigate whether 17β-estradiol (E2) tamoxifen (TAM) mediate proliferation apoptosis endometrial cancer cells through MAPK pathway.The expressions phosphorylated total extracellular signal-regulated kinases 1/2 (phosphorylated [p-ERK1/2] ERK1/2 [t-ERK1/2]) analyzed with immunohistochemistry...
Retinoblastoma is an severe ophthalmic disease and the most common type intraocular malignant tumor, particularly in infants. Currently, few drugs therapies are available. Gene therapy has been considered to be a potential treatment cure cancer effectively Herpes simplex virus 1 thymidine kinase/ganciclovir (HSV‑TK/GCV) one of suicide gene that extensively studied. Numerous vitro vivo studied have shown this system can kill tumor cells, including liver lung cells. GCV used as antiviral drug,...
To evaluate the therapeutic effects of internal fixation with support plates and cannulated screws via posterolateral approach on supination external rotation stage IV ankle fracture.Eighty-five patients SER-IV° fracture large posterior malleolar treated from June 2016 to 2018 in our hospital, were randomly divided into a plate group (n=47) screw (n=38). The treatment outcomes compared regarding surgical time, amount bleeding, time healing, postoperative complications, as well American...
Objective to summarize the clinical features and laboratory findings of 28 Chinese children with hereditary spherocytosis (HS), analyze these mutations.Collected analyzed data all their parents, completed relevant examinations children. Analyzed sequence related genes by second-generation sequencing technology, verified suspected mutations Sanger method. biological information using Single Nucleotide Polymorphism database, 1000 Human Genome Project, Exosome Aggregation Consortium.New were...
To investigate the abundance and potential functions of LAP+CD4+ T cells in colorectal cancer (CRC).Proportions were examined peripheral blood tumor/paratumor tissues CRC patients healthy controls using flow cytometry. Expression phenotypic markers such as forkhead box (Fox)p3, cytotoxic T-lymphocyte-associated protein (CTLA)-4, chemokine CC receptor (CCR)4 CCR5 was measured LAP-CD4+ isolated a magnetic cell-sorting system cell purity analyzed by Real-time quantitative polymerase chain...
Abstract Patients with chronic ankle instability (CAI) have postural-control deficits during center-of-pressure excursions than do healthy individuals. While an external analysis of in CAI has been performed, a quantitative center-of-gravity movements, to detect the balance associated CAI, yet be performed. Therefore, aim study is quantify patients unilateral CAI. Forty-four (24 men; age, 31.7 ± 5.5 years) and 26 uninjured volunteers (12 28.6 5.9 underwent Neurocom Balance Manager...