A5100680146- Cancer, Hypoxia, and Metabolism
- Autophagy in Disease and Therapy
- Cancer-related molecular mechanisms research
- Angiogenesis and VEGF in Cancer
- RNA modifications and cancer
- Inflammasome and immune disorders
- Extracellular vesicles in disease
- Cancer, Lipids, and Metabolism
- Thermal Expansion and Ionic Conductivity
- Endometriosis Research and Treatment
- Oral microbiology and periodontitis research
- interferon and immune responses
- Treatment of Major Depression
- Advanced Condensed Matter Physics
- Adipokines, Inflammation, and Metabolic Diseases
- Congenital Diaphragmatic Hernia Studies
- Zebrafish Biomedical Research Applications
- Atherosclerosis and Cardiovascular Diseases
- Temporomandibular Joint Disorders
- Congenital Anomalies and Fetal Surgery
- Melanoma and MAPK Pathways
- Endoplasmic Reticulum Stress and Disease
- MicroRNA in disease regulation
- Obstructive Sleep Apnea Research
- Periodontal Regeneration and Treatments
Shandong First Medical University
2014-2020
Shandong Tumor Hospital
2014-2020
Renji Hospital
2006-2019
Shanghai Jiao Tong University
2018-2019
Tianjin Medical University General Hospital
2019
Hefei University of Technology
2018
Beijing Anzhen Hospital
2017
Capital Medical University
2017
Jingdezhen Ceramic Institute
2015
Air Force General Hospital PLA
2015
Atherosclerosis is a chronic disease comprising intima malfunction and arterial inflammation. Recent studies have demonstrated that autophagy could inhibit inflammatory response in atherosclerosis exert subsequent atheroprotective effects. Our previous study also the role of inhibition inflammation by atorvastatin vitro. Therefore, present study, we aimed to determine whether upregulate cytokines secretion, lipid accumulation, improve vulnerable plaque stability, both vitro vivo. First,...
Abstract Macrophages play crucial roles in immune response and atherosclerosis‐related cardiovascular disease. Recent evidence of macrophage autophagy has demonstrated a novel pathway through which contributes to vascular inflammation. The aim this study was elucidate the role inhibition inflammatory macrophages by atorvastatin. We found that atorvastatin promoted flow determined up‐regulating expression autophagy‐related protein microtubule‐associated light chain (LC3B), inducing formation...
Bone marrow stromal cells (BMSCs) play a critical role in multiple myeloma (MM) pathogenesis by cell contact, and secretion of cytokines, growth factors extracellular vesicles. Exosomes are secreted almost all types recently reported to mediate local cell-to-cell cross-talk transferring messenger RNAs, LncRNAs, proteins. Compelling studies have identified BMSC-derived exosomes induce proliferation, migration, survival, drug resistance MM cells. However, whether cell-derived exosome also...
Abstract Hypoxia inducible factor‐1α (HIF‐1α) is a key determinant of oxygen‐dependent gene regulation in angiogenesis. HIF‐1α overexpression may be beneficial cell therapy hypoxia‐induced pathophysiological processes, such as ischemic heart disease. To address this issue, human peripheral blood mononuclear cells (PBMNCs) were induced to differentiate into endothelial progenitor (EPCs), and then transfected with either an HIF‐1α‐expressing or control vector cultured under normoxia hypoxia....
Abstract The vulnerable plaque is a key distinguishing feature of atherosclerotic lesions that can cause acute atherothrombotic vascular disease. This study was designed to explore the effect autophagy on mitochondria‐mediated macrophage apoptosis and plaques. Here, we generated mouse model carotid in ApoE −/− mice. Application mice with rapamycin (an inducer) inhibited necrotic core formation plaques by decreasing apoptosis. However, 3‐methyladenine inhibitor) promoted vulnerability through...
RNA interference is applied to study gene function in different organisms and various cell types. Little known about the effect of on human endothelial progenitor cells (EPCs) vitro. To address this issue, short hairpin targeting hypoxia inducible factor-1α (HIF-1α) was transferred into EPCs by an adenoviral vector. HIF-1α mRNA protein expression dramatically specifically downregulated after adeno-small interfering (siRNA)-HIF-1α infection under hypoxia, a condition which would have been...
Objective Prenatal diagnosis of total anomalous pulmonary venous connection ( TAPVC ) by fetal echocardiography FE remains a challenge. We sought to ascertain the diagnostic accuracy 2D and 3D spatiotemporal image correlation STIC potential incremental value for prenatal assessment . Methods This study was conducted retrospectively in single tertiary referral center. The population consisted 74 from 17 063 fetuses August 2010 April 2016. volume acquisition also performed Results A...
Malignant melanomas are amongst the most aggressive cancers. BRAF Inhibitors have exhibited therapeutic effects against BRAF-mutant melanoma. In continuation of our earlier studies on anti-melanoma agents based 1H-pyrazole skeleton, two sets novel compounds that include 1H-pyrazole-4-amines FA1 - FA13 and corresponding urea derivatives FN1 FN13 been synthesized evaluated for their BRAFV600E inhibitory antiproliferation activities. Compound FN10 displayed potent biological activity (IC50 =...
Dendritic cells (DCs) are professional antigen-presenting and have an important role in the pathogenesis of atherosclerosis. It has been confirmed that optimal oxLDL dose can induce considerable RAW264.7 differentiate into dendritic-like our previous work. In this study, we examined whether atorvastatin could inhibit differentiation mature macrophages DCs induced by which pathway involved process. After 24 h treatment with (20 umol/ml), almost all simultaneously remained cell size morphology...