A5064748220- Immune Cell Function and Interaction
- Hematopoietic Stem Cell Transplantation
- Peptidase Inhibition and Analysis
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Multiple Myeloma Research and Treatments
- Immune cells in cancer
- Cancer-related molecular mechanisms research
- Cancer Mechanisms and Therapy
- Immunodeficiency and Autoimmune Disorders
- Molecular Sensors and Ion Detection
- Supramolecular Chemistry and Complexes
- Mesenchymal stem cell research
- Platelet Disorders and Treatments
- Autophagy in Disease and Therapy
- Systemic Lupus Erythematosus Research
- Acute Myeloid Leukemia Research
- Lymphoma Diagnosis and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Viral-associated cancers and disorders
- Hematological disorders and diagnostics
- Crystallography and molecular interactions
- Bone and Joint Diseases
- Reproductive System and Pregnancy
Nanjing Medical University
2025
Tianjin Medical University General Hospital
2015-2025
Yancheng Third People's Hospital
2025
Nankai University
2023-2024
Tianjin Medical University
2015-2023
Xi'an Jiaotong University
2021
Dalian Medical University
2020
Air Force Medical University
2012
Bone marrow stromal cells (BMSCs) play a critical role in multiple myeloma (MM) pathogenesis by cell contact, and secretion of cytokines, growth factors extracellular vesicles. Exosomes are secreted almost all types recently reported to mediate local cell-to-cell cross-talk transferring messenger RNAs, LncRNAs, proteins. Compelling studies have identified BMSC-derived exosomes induce proliferation, migration, survival, drug resistance MM cells. However, whether cell-derived exosome also...
Background and Purpose Hepatic fatty acid metabolism disorder, a key pathogenic mechanism underlying non‐alcoholic liver disease (NAFLD), is associated with the hyperacetylation of mitochondrial enzymes. Acyl‐CoA synthetase family member 3 (ACSF3), which involved in regulation metabolism, was predicted to contain lysine acetylation sites related deacetylase sirtuin (SIRT3). The purpose this study explore by SIRT3 deacetylates ACSF3 NAFLD protective effect natural phenolic compound...
<title>Abstract</title> <bold>Background</bold>: Immune dysfunction is a major component in the pathogenesis of multiple myeloma (MM), and restoring antimyeloma immunity has become key research direction. <bold>Methods</bold>: This study demonstrates, through <italic>in vivo</italic> vitro</italic> experiments, whether how Pim-2 kinase inhibitors induce immunogenic cell death MM. <bold>Results</bold>: upregulated IRE1 phosphorylation promoted XBP1 CHOP transcription, thereby mediating...
Antibody‑drug conjugates (ADCs) are rapidly advancing the treatment of solid tumors, and Nectin‑4‑targeted ADCs have been approved by FDA to treat certain cancers. Although Nectin‑4 is overexpressed in tissues patients with pancreatic cancer, whether can effectively cancer remains unclear. The present study evaluated therapeutic effects mechanisms cancer. A Nectin‑4‑directed ADC was chosen, Nectin‑4‑MMAE, which triggered apoptosis induced cell death Nectin‑4‑positive lines BxPC‑3 YAPC....
The pursuit of synthetic receptors with high binding affinities has long been a central focus in supramolecular chemistry, driven by their significant practical relevance various fields. Despite the numerous that have developed, most exhibit micromolar range or lower. Only few exceptional achieve exceeding 10
Pim-2 is a serine/threonine protein kinase that highly expressed in various types of cancer, with essential roles the regulation signal transduction cascades, which promote cell survival and proliferation. The present study demonstrated Pim‑2 was cells lines derived from hematopoietic tumors lung cancer. In vitro, downregulation by short interfering RNA inhibited proliferation delayed G0/G1 cycle progression K562 leukemia, RPMI‑8226 multiple myeloma, H1299 A549 non‑small carcinoma lines....
Severe aplastic anemia (SAA) is an autoimmune disease in which bone marrow failure mediated by activated myeloid dendritic cells (mDCs) and T lymphocytes. Recent research has identified a strong immunomodulatory effect of pyruvate kinase M2 (PKM2) on immune‐mediated diseases. In this study, we aimed to explore the role PKM2 activation mDCs SAA. We observed conspicuously higher levels from SAA patients compared normal controls at both gene protein levels. Concurrently, unexpectedly discovered...
In recent years we have observed that some patients with idiopathic cytopenia of undetermined significance (ICUS) responded well to corticosteroid and high-dose intravenous immunoglobulin treatment, indicating in ICUS might be mediated by autoantibodies. this study, analysed 166 cases retrospectively, which were autoantibodies detected on haemopoietic cells bone marrow (BM) BM mononuclear cell (BMMNC)-Coombs test, flow cytometry (FCM), Western blot immunofluorescence (IF). We found 25·9% (43...
Severe aplastic anemia (SAA) is characterized by pancytopenia and failure of hematopoietic function caused excessive functioning cytotoxic T lymphocytes (CTLs). EBNA-1, a nucleoprotein the Epstein Barr virus (EBV), can influence proliferation lymphocytes. We therefore tested number EBV copies in CD8+ cells 27 patients with SAA 10 healthy control subjects observed influences EBNA-1 upon SAA. The results showed that more were found untreated than remission or subjects. Their copy was...
Abstract Background Regulatory T cells (Tregs) inhibit the activation of cluster differentiation (CD) 4 + , CD8 and antigen‐presenting process cells, may play an important role in acquired severe aplastic anemia (SAA). Methods Flow cytometry was used to measure CD4 CD25 CD127 dim Tregs, cytotoxic lymphocyte antigen (CTLA‐4) expression on human leukocyte (HLA)‐DQ myeloid dendritic (mDCs). The correlations CTLA‐4 HLA‐DQ with immune status clinical indicators changes these after...
Interleukin (IL)-35 is the latest member of IL-12 family, which plays an important role in other autoimmune diseases. Bone marrow mononuclear cells Coombs test‑positive hemocytopenia, also termed immunorelated hemocytopenia (IRH) a type autoimmune-associated The present study investigated relationship IL‑35 patients with IRH. A total 43 IRH and 19 normal controls were enrolled current study. Serum levels IL‑17 peripheral blood evaluated by ELISA. Regulatory T (Tregs) level was detected flow...
Objective . We studied bone marrow plasma (BMP) cytokines in severe aplastic anemia (SAA) patients and healthy volunteers to investigate differences the cytokine profiles between them propose a signature of SAA. Methods A Bio‐Plex suspension array system was used measure 27 analytes BMP samples from 47 SAA 30 donors. Results Compared people, had higher levels tumor necrosis factor α (TNF‐ ), interferon‐ γ (IFN‐ interleukin‐2 (IL‐2), monocyte chemoattractant protein 1 (MCP‐1), granulocyte...
This study is aimed at investigating the effects of shikonin, a pyruvate kinase M2 (PKM2) inhibitor, on functions myeloid dendritic cells (mDCs) in mouse model severe aplastic anemia (AA) generated by total body irradiation and lymphocyte infusion. Flow cytometry qPCR were used to determine proportions PKM2+ mDCs other immune indicators AA mice. Glucose consumption level, generation ATP content level glycolytic metabolism mDCs. The survival rates mice evaluated after administration shikonin...
The mechanism of non-severe aplastic anemia (NSAA) is not clear. It may be different from severe (SAA). CD56bright NK cells (regulatory cells) a subgroup that produce immunoregulatory cytokines and express high-affinity IL-2 receptor. To investigate quantities function in patients with NSAA to explore how participate the progress this disease.In study, we analyzed quantitative functional changes peripheral blood by using Flow Cytometry (FCM) before after immunosuppressive therapy (IST)....
To investigate the clinical application value of peripheral blood metagenomic next-generation sequencing (mNGS) test for patients with hematological diseases accompanied by fever.
To investigate the change of autophagy level bone marrow mononuclear cells（BMMNCs）in patients with myelodysplastic syndromes（MDS）.
Background: Suicide rate is much higher in cancer patients than general population. This study examined the suicide risk survivors of primary solid tumor across 19 sites considering coincident patterns based on area-based SES indicators. Methods: A retrospective search SEER database was conducted. Independent factors for were identified using Cox proportional-hazards model. Exploratory factor analysis and cluster used to create factors. Results: with a who older, male, white, unmarried, had...
Abstract The precise recognition and sensing of steroids, a type vital biomolecules, hold immense practical value across various domains. In this study, we introduced corral[4]BINOLs ( C[4]BINOL s), pair enantiomeric conjugated deep‐cavity hosts, as novel synthetic receptors for binding steroids. Due to the strong hydrophobic effect their deep nonpolar, chiral cavities, two enantiomers s demonstrated exceptionally high affinities (up 10 12 M −1 ) 16 important steroidal compounds well good...
再生障碍性贫血（AA）是一种骨髓造血功能衰竭的自身免疫性疾病。由于移植和免疫抑制治疗方案的不断进步，AA患者的生存期明显提高，但仍有部分患者未从中受益。这使得深入研究AA发病机制非常必要，本文就AA最新的发病机制进行综述。.