A5103071967- Immune Cell Function and Interaction
- Hematopoietic Stem Cell Transplantation
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Immunodeficiency and Autoimmune Disorders
- Reproductive System and Pregnancy
- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- Ultrasound and Hyperthermia Applications
- Gestational Diabetes Research and Management
- Pregnancy and preeclampsia studies
- Maritime Ports and Logistics
- Hematological disorders and diagnostics
- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Porphyrin Metabolism and Disorders
- Folate and B Vitamins Research
- Mesenchymal stem cell research
- Multiple Myeloma Research and Treatments
- GDF15 and Related Biomarkers
- Maritime Transport Emissions and Efficiency
- Platelet Disorders and Treatments
- Chronic Lymphocytic Leukemia Research
- Diagnosis and Treatment of Venous Diseases
- Prostate Cancer Treatment and Research
Nanchang University
2020-2024
Tianjin Medical University General Hospital
2014-2024
Yichang Central People's Hospital
2024
China Three Gorges University
2024
Second Affiliated Hospital of Nanchang University
2024
Dongbei University of Finance and Economics
2023
Tianjin Medical University
2014-2022
First Affiliated Hospital of Nanchang University
2020
Abstract Background Glucagon‐like peptide 1 (GLP‐1) and its analogs are first‐line choices for the treatment of type 2 diabetes mellitus. Recent studies have shown that they exhibit antitumor properties in some tumors. We previously found a GLP‐1 analog, exendin‐4 (Ex‐4), inhibited growth prostate cancer cells through suppressing PI3K/Akt/mTOR pathway, which is activated response to enzalutamide reported be closely related resistance enzalutamide. So we speculated may enhance sensitivity...
Neoadjuvant therapy has become a mainstay of treatment for locally advanced resectable esophageal cancer. The objective this research was to investigate the effectiveness and safety neoadjuvant immunotherapy combined with chemotherapy in treating surgically removable squamous cell carcinoma (ESCC).
Abstract Background Regulatory T cells (Tregs) inhibit the activation of cluster differentiation (CD) 4 + , CD8 and antigen‐presenting process cells, may play an important role in acquired severe aplastic anemia (SAA). Methods Flow cytometry was used to measure CD4 CD25 CD127 dim Tregs, cytotoxic lymphocyte antigen (CTLA‐4) expression on human leukocyte (HLA)‐DQ myeloid dendritic (mDCs). The correlations CTLA‐4 HLA‐DQ with immune status clinical indicators changes these after...
Interleukin (IL)-35 is the latest member of IL-12 family, which plays an important role in other autoimmune diseases. Bone marrow mononuclear cells Coombs test‑positive hemocytopenia, also termed immunorelated hemocytopenia (IRH) a type autoimmune-associated The present study investigated relationship IL‑35 patients with IRH. A total 43 IRH and 19 normal controls were enrolled current study. Serum levels IL‑17 peripheral blood evaluated by ELISA. Regulatory T (Tregs) level was detected flow...
Objective . We studied bone marrow plasma (BMP) cytokines in severe aplastic anemia (SAA) patients and healthy volunteers to investigate differences the cytokine profiles between them propose a signature of SAA. Methods A Bio‐Plex suspension array system was used measure 27 analytes BMP samples from 47 SAA 30 donors. Results Compared people, had higher levels tumor necrosis factor α (TNF‐ ), interferon‐ γ (IFN‐ interleukin‐2 (IL‐2), monocyte chemoattractant protein 1 (MCP‐1), granulocyte...
The patients with severe aplastic anemia (SAA) usually rely on red cell transfusion which lead to secondary iron overload. Transforming growth differentiation factor-15 (GDF-15) plays an important role in erythropoiesis and regulation. In this study, we investigated the level of GDF-15 other indexes metabolism SAA explore correlation overload SAA.The levels serum GDF-15, hepcidin (Hepc), erythropoietin (EPO) were determined by ELISA. (SI), ferritin, TIBC, transferrin saturation (TS) measured...
This study is aimed at investigating the effects of shikonin, a pyruvate kinase M2 (PKM2) inhibitor, on functions myeloid dendritic cells (mDCs) in mouse model severe aplastic anemia (AA) generated by total body irradiation and lymphocyte infusion. Flow cytometry qPCR were used to determine proportions PKM2+ mDCs other immune indicators AA mice. Glucose consumption level, generation ATP content level glycolytic metabolism mDCs. The survival rates mice evaluated after administration shikonin...
Abstract Introduction Severe aplastic anemia (SAA) is a disease characterized by severe pancytopenia and hematopoietic failure of bone marrow. Natural killer (NK) cells are class large granular lymphocytes that perform killing immunomodulatory functions. Our previous study demonstrated NK played the “protective” role in SAA, which weakened. However, mechanism remains unclear. Methods Peripheral blood from SAA patients normal controls were sorted total proteins extracted. Then, mass...
To assess the short-term efficacy and safety of ixazomib in Chinese multiple myeloma (MM) patients real world.Fifty-nine MM who received at least one cycle ixazomib-based therapy between 1 June 2018 30 September 2019 were retrospectively analyzed Tianjin Medical University General Hospital. Thirteen newly diagnosed (NDMM), 13 refractory/relapsed (RRMM) 33 continuous (27 bortezomib peripheral neuritis (PN) intolerant six maintenance therapy) included. The indicated overall response rate...
U To analyze the effect of metformin hydrochloride combined with insulin pump for gestational diabetes mellitus (GDM).Overall, 216 patients GDM in Zhangqiu Maternity and Child Care Hospital, Jinan, China from Aug 2018 to Dec 2020 were enrolled randomized into research control groups. Patients group treated pump, while those pump. The clinical efficacy, blood glucose levels, serum Betatrophin, C reactive protein (CRP), Cystatin (Cys-C), homocysteine (Hcy), adiponectin, tumor necrosis factor...
To investigate predictors of anticoagulation efficacy in deep venous thrombosis (DVT) by ultrasound elastography (UE).
In the past decade, a group of cases with persisting haemocytopenia were separated from those idiopathic cytopenia undetermined significance due to optimal response these patients immunosuppression therapy and detection autoantibodies in bone marrow haemopoietic cells. This condition was termed immune‑related (IRH). However, quantity T lymphocytes remained unknown. present study, percentage CD4+ T‑cell subsets related cytokines measured using flow cytometry an enzyme‑linked immunosorbent...
Severe aplastic anemia (SAA) is a bone marrow failure disorder caused by autoimmune dysfunction. The presentation dendritic cells (DCs) the key step in initiating immune response against unknown antigens SAA patients. Circulating myeloid/conventional (mDCs/cDCs) are increased patients with SAA, compared to healthy individuals. In this study, we investigated expression of HLA-DQ cDCs and its impact on downstream effector T systemic system level was significantly higher than normal control...
Severe aplastic anemia (SAA) is a bone marrow failure disorder caused by autoimmune dysfunction. The presentation dendritic cells (DCs) the key step in initiating immune response against unknown antigens SAA patients. In previous phase, we found that compared to healthy controls, patients with had an increased proportion of circulating myeloid/conventional (mDCs/cDCs) enhanced phagocytosis, more secretion Th1-type cytokines (IL-2, TNF-α, IFN-γ) marrow, and reduced Treg cells. this study,...