A5101873755- Multiple Myeloma Research and Treatments
- Immune Cell Function and Interaction
- Peptidase Inhibition and Analysis
- Acute Myeloid Leukemia Research
- Immunotherapy and Immune Responses
- Glaucoma and retinal disorders
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- T-cell and B-cell Immunology
- Cancer Mechanisms and Therapy
- RNA Interference and Gene Delivery
- Platelet Disorders and Treatments
- Immunodeficiency and Autoimmune Disorders
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Protein Degradation and Inhibitors
- Retinal Diseases and Treatments
- Blood groups and transfusion
- Hematopoietic Stem Cell Transplantation
- Cancer Cells and Metastasis
- Complement system in diseases
- Ubiquitin and proteasome pathways
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Histone Deacetylase Inhibitors Research
- RNA regulation and disease
University of Oklahoma Health Sciences Center
2014-2025
Tianjin Medical University General Hospital
2016-2025
Tianjin haihe hospital
2025
State Key Laboratory of Chemical Engineering
2025
Wuhan University
2022-2024
Soochow University
2018-2023
Dean McGee Eye Institute
2023
Nantong University
2023
Tianjin Medical University
2012-2022
Second Military Medical University
2015-2021
The main obstacle of multiple myeloma (MM) therapy is the compromised immune microenvironment, which leads to MM relapses and extramedullary disease progression. In this study, a novel strategy reported enhanced immunogenic cell death (ICD) immunotherapy with aggregation-induced emission (AIE) photosensitizer-loaded bovine serum albumin (BSA) nanoparticles (referred as BSA/TPA-Erdn), can activate T cells, convert cold tumor hot, reverse senescence restore microenvironment for treatment....
Nasopharyngeal carcinoma (NPC) is among the most common squamous cell in South China and Southeast Asia. Radiotherapy primary treatment for NPC. However, radioresistance acts as a significant factor that limits efficacy of radiotherapy NPC patients. Growing evidence supports microRNAs (miRNAs) play an important role radiation response. Real-time quantitative PCR was used to analyze expression miR-19b-3p lines NP69. profiles tissues were obtained from Gene Expression Omnibus database. The...
Abstract Src homology region 2 (SH2) domain–containing phosphatase 1 (SHP-1, also known as PTPN6) is a nonreceptor protein tyrosine that acts negative regulator of inflammation. Emerging evidence indicates SHP-1 plays role in inhibiting the progression hepatocellular carcinoma (HCC). However, hepatocarcinogenesis remains unknown. Here, we find levels are significantly downregulated human HCC tissues compared with those noncancerous (P < 0.001) and inversely correlate tumor diameters...
Our previous study has demonstrated that hepatocyte nuclear factor 1α (HNF1α) exerts potent therapeutic effects on hepatocellular carcinoma (HCC). However, the molecular mechanisms by which HNF1α reverses HCC malignancy need to be further elucidated.lncRNA microarray was performed identify long noncoding RNAs (lncRNAs) regulated HNF1α. Chromatin immunoprecipitation and luciferase reporter assays were applied clarify mechanism of transcriptional regulation HNF1A antisense RNA 1 (HNF1A-AS1)....
Immune effector cells in patients with multiple myeloma (MM) are at the forefront of many immunotherapy treatments, and several methods have been developed to fully utilise antitumour potential immune cells. T NK cell-derived lymphocytes both expressed activating receptor group 2 member D(NKG2D). This can identify eight distinct NKG2D ligands (NKG2DL), including major histocompatibility complex class I (MHC) chain-related protein A B (MICA MICB). Their binding triggers roles NKG2DL is...
The liver-enriched transcription factor Forkhead Box A2 (FOXA2) has been reported to be involved in bile acid homeostasis and duct development. However, the role of FOXA2 liver fibrogenesis remains undefined. In this study, we found that abundance was significantly lower fibrotic livers patients mice treated with CCl4 than controls. Interestingly, expression level decreased hepatocytes, whereas elevated hepatic stellate cells (HSCs) mouse livers. Hepatocyte-specific ablation adult...
The purpose of this study was to evaluate the safety and efficacy microinvasive glaucoma surgery (MIGS) with 360° ab-interno trabeculotomy using TRAB360 device as a stand-alone procedure in patients refractory primary open-angle (POAG) preoperative IOP ≥18 mmHg.This evaluated treated tertiary-referral clinical practice setting.This is retrospective analysis 81 eyes.Patients underwent device. Effectiveness determined by reduction medicated use medications from baseline. Safety rate adverse...
This study aimed to investigate the associations between social jetlag (SJL), dietary behavior, physical activity, and weight status in Chinese youth. Data were derived from a cross-sectional survey Wuhan, China 2019. Information on SJL, frequency of food beverage consumption, BMI category collected via self-reported questionnaire. The Kruskal-Wallis test ANOVA conducted determine differences daily consumption groups, category, activity among SJL groups. Logistic regressions restricted cubic...
Myeloma bone disease (MBD) is the most common complication of multiple myeloma (MM). Our previous study showed that complement C3a activates osteoclasts to participate in pathogenesis MBD; however, its mechanism action diverse and complex. Studies have shown Sirtuin (Sirt) family proteins (i.e., Sirt1–7) are expressed human cartilage, metabolic balance. We measured levels C3a, Sirt1, osteoclast-related genes, disease-related biological indicators using enzyme-linked immunosorbent assay...
Preventing Chronic Disease (PCD) is a peer-reviewed electronic journal established by the National Center for Prevention and Health Promotion. PCD provides an open exchange of information knowledge among researchers, practitioners, policy makers, others who strive to improve health public through chronic disease prevention.
Objective To evaluate the prescribing trends of glaucoma drugs in six major cities China from 2013 to 2017. Methods A descriptive analysis using pharmacy prescription data was conducted. Outpatient extracted Hospital Prescription Analysis Cooperative Project. Prescribing patterns, visits, and corresponding expenditures for medications were analyzed. Results total 84297 ambulatory prescriptions included current study. Visits by patients increased 13808 20060 Over same period, yearly...
Abstract Metabolic reprogramming in cancer cells plays a crucial role development, metastasis and invasion. Cancer have unique metabolism profile that could switch between glycolysis oxidative phosphorylation (OXPHOS) order to satisfy higher proliferative rate enable survival tumor microenvironment. Although dietary-based starvation therapy has shown some positive outcomes for treatment, it is difficult patients persist long time due the adverse effects. Here this study, we developed...
Osteoporosis is one of the bone-metabolic diseases associated with decreased bone renewal and mineral density. β-aminoisobutyric acid (BAIBA), a natural thymine catabolite, can reduce inflammation in skeletal muscle alleviate hepatic endoplasmic reticulum stress. However, roles BAIBA osteoblast proliferation differentiation remain largely unknown.The cultured MC3T3-E1 cells received various treatments this study, including alone, H2O2 plus N-acetyl-l-cysteine apocynin. Cell was determined by...
Abstract Invasive lobular carcinoma (ILC) is a histological subtype of breast cancer with distinct molecular and clinical features from the more common invasive ductal (IDC). ILC cells exhibit anchorage-independent growth in ultra-low attachment (ULA) suspension cultures, which largely attributed to loss E-cadherin. In addition anoikis resistance, herein we show that human cell lines enhanced proliferation ULA cultures as compared IDC cells. Proteomic comparison identified induction PI3K/Akt...
To investigate the expression of preferentially expressed antigen melanoma (PRAME) gene in acute leukemia and its clinical significance.The level PRAME mRNA bone marrow mononuclear cells from 34 patients with (AL) 12 samples healthy volunteers was measured via RT-PCR. Correlation analyses between characteristics (gender, age, white blood count, immunophenotype leukemia, percentage blast cells, karyotype) were performed.The 38.2% all patients, 40.7% myelogenous (AML, n=27), 28.6%...