A5090130081- Multiple Myeloma Research and Treatments
- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Protein Degradation and Inhibitors
- Platelet Disorders and Treatments
- Peptidase Inhibition and Analysis
- Viral-associated cancers and disorders
- CNS Lymphoma Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Cancer Treatment and Pharmacology
- Blood groups and transfusion
- Cancer-related molecular mechanisms research
- Cardiovascular Disease and Adiposity
- Atrial Fibrillation Management and Outcomes
- Eosinophilic Disorders and Syndromes
- Cardiac Arrhythmias and Treatments
- Acute Myeloid Leukemia Research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Hematopoietic Stem Cell Transplantation
- Cancer, Lipids, and Metabolism
- Cardiovascular Effects of Exercise
- Bone health and treatments
- Histone Deacetylase Inhibitors Research
- Amino Acid Enzymes and Metabolism
Inner Mongolia Medical University
2012-2025
Ningbo Medical Center Lihuili Hospital
2019-2024
Inner Mongolia Medical College Hospital
2006-2024
Ningbo University
2023
Mongolian National University of Medical Sciences
2023
Weatherford College
2019
Institute of Cardiology
2019
Air Force Medical University
2000-2002
Xijing Hospital
2000-2002
ABSTRACT Long non‐coding RNAs (lncRNAs) can participate in the pathological process of multiple myeloma (MM) via regulation specific gene expression and function. This research aimed to study role MALAT‐1 underlying mechanism MM. In this study, HMGB1 protein bone marrow mononuclear cells from MM patients at different stages cell lines was determined by qRT‐PCR western blot, respectively. The endogenous modulated using lentivirus vectors transfection. CHX chase assay RIP analyses were...
microRNAs (miRNAs) are of importance to chronic heart failure (CHF). However, the relevance exosomal miRNAs produced during CHF remains unknown. Our purpose here was examine microRNA-1246 (miR-1246) released from human umbilical cord mesenchymal stem cell (hucMSC) and mechanism action. Cardiac function, myocardial infarction area, apoptosis, angiogenesis were all evaluated in a rat model following treatment with hucMSC-derived exosomes (hucMSC-Exos). H9C2 vascular endothelial cells (HUVECs)...
Objective Hypertension is the most challenging public health problem worldwide and seriously affects human health. To date, there are no epidemiological studies on prevalence of risk factors for hypertension among older people in mainland China. Methods We conducted a meta-analysis population searched Chinese English databases literature epidemiology published between 2000 2022, data were extracted from included literature. A was performed using random-effects model ( I 2 > 50%) with...
Corticosteroids (CSs) are the initial therapy for immune thrombocytopenia (ITP); however, their efficacy is not adequately predicted. As a novel biomarker, composition of gut microbiota non-invasively tested and altered in patients with ITP. This study aims to develop predictive model that leverages microbiome data predict CS response ITP within four weeks treatment. Metagenomic sequencing performed on fecal samples from 212 ITP, 152 whom underwent treatment follow-up. Predictive models...
This registration study assessed clinical outcomes of TQ-B3525, the dual phosphatidylinositol-3-kinase (PI3K) α/δ inhibitor, in relapsed and/or refractory follicular lymphoma (R/R FL). phase II (ClinicalTrials.gov NCT04324879. Registered March 27, 2020) comprised run-in stage and 2. R/R FL patients after ≥2 lines therapies received oral 20 mg TQ-B3525 once daily a 28-day cycle until intolerable toxicity or disease progression. Primary endpoint was independent review committee (IRC)-assessed...
To evaluate the effectiveness, safety, and convenience of in-class transition (iCT) from intravenous bortezomib-based induction to ixazomib-based oral regimens.
Rare but critical bleeding events in primary immune thrombocytopenia (ITP) present life-threatening complications patients with ITP, which severely affect their prognosis, quality of life, and treatment decisions. Although several studies have investigated the risk factors related to large sample size data, consistent definitions, large-scale multicenter findings, prediction models for ITP are unavailable. For first time, this study, we applied newly proposed criteria by International...
HLA‐A*26:01:81 differs from HLA‐A*26:01:01:01 by one nucleotide in exon 4.
Abstract Purpose The synergistic effects of combining arsenic compounds with imatinib against chronic myeloid leukemia (CML) have been established using in vitro data. We conducted a clinical trial to compare the efficacy realgar–indigo naturalis formula (RIF) plus that monotherapy patients newly diagnosed phase CML (CP-CML). Methods In this multicenter, randomized, double-blind, 3 trial, 191 outpatients CP-CML were randomly assigned receive oral RIF (n = 96) or placebo 95). primary end...
Abstract Although many efforts have contributed to improve our knowledge of molecular pathogenesis about multiple myeloma ( MM ), the role and significance micro RNA s long noncoding in cells, along with core mechanism remains virtually absent. The mRNA levels miR‐125b MALAT 1 cell lines were detected by qRT ‐ PCR . influence Lenti‐Sh‐miR‐125b on viability Notch‐1 pathway‐related proteins assessed MTT method western blot, respectively. We also investigated regulation effect between Notch1...
Multiple myeloma is a disease of the older people, whose prognoses are highly heterogeneous. The International Myeloma Working Group (IMWG) proposed geriatric assessment (GA) based on age, functional status and comorbidities to discriminate between fit frail patients. Given multidimensional nature frailty relatively recent exploration in field MM, reaching consensus measurement MM patients remains challenging.We sought assess feasibility performing comprehensive GA (CGA) real-world...
QL0911, a recombinant human thrombopoietin mimetic peptide-Fc fusion protein, is romiplostim (Nplate®) biosimilar used to treat primary immune thrombocytopenia (ITP). This phase III study aimed assess the efficacy and safety of QL0911 in adult patients with chronic ITP over 24-week treatment period.We conducted double-blind, placebo-controlled, diagnosed for at least 12 months who had received one first-line no response or recurrence after treatment, relapsed splenectomy 44 sites China....
Abstract Recently, the monocyte count to high-density lipoprotein cholesterol ratio (MHR) was found be associated with SYNTAX score in patients both stable coronary artery disease (CAD) and acute syndrome (ACS). The MHR significantly higher male patients. However, sex-specific association of CAD not well explored. Thus, present study aimed investigate presence severity evaluated by angiography males females. In total, 873 who received selective between March 2017 July 2018 were included...
Lipoprotein(a) (Lp(a)) is associated with the severity of coronary lesions evaluated using Syntax score in patients stable artery disease (CAD). However, effect low-density lipoprotein cholesterol (LDL-C) levels on association Lp(a) remains unclear.A total 646 CAD were enrolled present study. measured an AU5800 Chemistry Analyzer. scores calculated by two advanced interventional cardiologists. SPSS 22.0 was used for statistical analyses.The concentration ranged from 1 to 192 mg/dL. Pearson's...
BACKGROUND: Circular RNAs (circRNAs) are the emerging informative RNAs, involved in cardiovascular diseases including atherosclerosis (AS). Endothelial injury is initial qualitative change of AS. Thus, objective this study was to confirm dysregulation and mechanism circ_0000231 cell model AS at early stage human umbilical vein endothelial cells (HUVECs) induced by oxidized low-density lipoprotein (ox-LDL). METHODS: The expression circ_0000231, miR-590-5p programmed death 4 (PDCD4) detected...
A subset of diffuse large B-cell lymphoma may show aberrant cyclin D1 expression, which be confused with blastoid mantle cell lymphoma. These cases usually lack CCND1 gene rearrangement. Duplication was attributed to some the expression. The mechanism overexpression in other not well documented.We report a case underlying for expression due an abnormal rearrangement involving BCL-6 and CCND1, different from most reported cases. Rare similar genetic profile were classified as lymphoma.The...
HLA-B*13:01:21 differs from HLA-B*13:01:01:01 by one nucleotide in exon 2.