A5114378335- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Vector-borne infectious diseases
- Heat shock proteins research
- Viral Infections and Vectors
- Circular RNAs in diseases
- Insect and Pesticide Research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Toxin Mechanisms and Immunotoxins
- Insect and Arachnid Ecology and Behavior
- Genomics, phytochemicals, and oxidative stress
- Adipose Tissue and Metabolism
- Iron Metabolism and Disorders
- Advanced biosensing and bioanalysis techniques
- Material Properties and Applications
- Venomous Animal Envenomation and Studies
- Topological Materials and Phenomena
- Powder Metallurgy Techniques and Materials
- Hippo pathway signaling and YAP/TAZ
- Fatty Acid Research and Health
- Nuclear Materials and Properties
- Periodontal Regeneration and Treatments
- Fluid Dynamics and Thin Films
- Reproductive biology and impacts on aquatic species
Stomatology Hospital
2025
Guizhou Normal University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2011-2023
Chongqing University
2023
Hebei Normal University
2016-2021
Tianjin Institute of Industrial Biotechnology
2021
Tianjin University of Science and Technology
2021
Southwest University
2019-2021
Fudan University Shanghai Cancer Center
2021
Fudan University
2021
Abstract Strand-selection is the final step of microRNA biogenesis in which functional mature miRNAs are generated from one or both arms precursor. The preference strand-selection diverse during development and tissue formation, however, its pathological effect still unknown. Here we find that two miRNA same precursor, miR-574-5p miR-574-3p, inversely expressed play exactly opposite roles gastric cancer progression. Higher-5p with lower-3p expression pattern significantly correlated higher...
The treatment of bone defects presents significant challenges in clinical practice. Guided regeneration (GBR) strategies offer a new approach, but existing commercial GBR membranes still lack optimal barrier and osteogenic functions. This study the design Janus fibrous membrane using classic amphiphilic block copolymers gelatin methacryloyl containing unsaturated double bonds through gradient electrospinning process. Specifically, by controlling parameters, self-assembly copolymers,...
Plant stem cells are hypersensitive to environmental hazards throughout their life cycle, but the mechanism by which plants safeguard cell homeostasis in response is largely unknown. The homeodomain transcription factor WUSCHEL (WUS) protein maintains pool shoot apical meristem of Arabidopsis. Here, we demonstrate that translation WUS mRNA directed an internal ribosomal entry site (IRES) located 5'-untranslated region. AtLa1 protein, RNA-binding factor, binds region and initiates...
Platycarya longipes is a dominant tree species in karst forests. Due to limited genomic information, its exact phylogenetic position within the family Juglandaceae remains unclear. In this study, complete chloroplast genome (cp genome) of was de novo assembled using Illumina reads. This circular cp 158 592 bp length, consisting an 88 066 large single-copy region, 18 524 small and total 26 001 derived from pair inverted repeats (IRa IRb), with average GC content 36.15%. It accommodated 113...
Abstract Depth-resolved, non-contact, full-field three-dimensional (3D) deformation measurement is essential for the application of hydrogels in biomimicry, soft robotics, and optical components. However, current methods are constrained to surface measurements encounter difficulties underwater settings. Leveraging 3D depth-resolved imaging capabilities coherence tomography (OCT), we propose an OCT-based method measuring water. This integrates electrically driven devices with a Limited-memory...
Abstract Background Ticks are notorious blood-feeding arthropods that can spread a variety of deadly diseases. The salivary gland is an important organ for ticks to feed on blood, and this begins develop rapidly when ixodid suck blood. When these reach critical weight, the glands stop developing begin degenerate. expression levels large number proteins during development degeneration change, which regulate biological functions glands. Furthermore, best our knowledge, there only few reports...
Babesia is a protozoan parasite that infects red blood cells in some vertebrates. Some species of can induce zoonoses and cause considerable harm. As the largest immune organ mammals, spleen plays an important role defending against infection. When infected with Babesia, seriously injured but still actively initiates immunomodulatory responses.To explore molecular mechanisms underlying regulation self-repair response to infection, this study used data-independent acquisition (DIA)...
The short-chain dehydrogenases/reductases (SDR) superfamily is involved in multiple physiological processes. In this study, genome-wide identification and comprehensive analysis of SDR were carried out 29 animal species based on the latest genome databases. Overall, number genes animals increased with whole duplication (WGD), suggesting expansion SDRs during evolution, especially 3R-WGD polyploidization teleosts. Phylogenetic indicated that vertebrates clustered into five categories:...
Glutathione S-transferases (GSTs) are phase II detoxification enzymes, which function via combining with pesticidal molecules and catalyzing the conjugation of by thiol glutathione, so as to protect tissues from oxidative stress damage. In tick Haemaphysalis longicornis, glutathione (HlGST HlGST2) have been previously identified. However, relationship between transcription essential oil treatment in ticks remains unexplored. Hence, present study, profiles HlGST HlGST2 mRNAs were evaluated H....
Abstract Background: The tick Haemaphysalis longicornis is well known as vector of several zoonotic pathogens responsible for various clinical conditions, increasingly threatens the veterinary and public health. It mainly distributed in East Asia, New Zealand, Australia, Pacific islands, has been expanded rapidly United States since its first founding on a nonimported domestic sheep Jersey. Glutathione S-transferases (GSTs) are phase II detoxification enzymes, which function via combining...
Xenopus laevis tolerate dehydration when their environments evaporate during summer months. Protein phosphorylation has previously shown to regulate important adaptations in X. laevis, including the transition anaerobic metabolism. We therefore performed phosphoproteomic analysis of further elucidate cellular and metabolic responses dehydration. Phosphoproteins were enriched functions pathways related glycolysis/gluconeogenesis, TCA cycle, protein metabolism, among others. The prominence...
Abstract Background Interferon-alpha (IFN-α) is a general therapeutic regimen to be utilized in hepatocellular carcinoma (HCC). However, regulatory mechanisms of IFN-α on competing endogenous RNAs (ceRNAs) level anti-HCC relapse are rarely understood. Methods HCC patients with and without treatment were calculated analyze the expression profile mRNA, long non-coding RNA (lncRNA), microRNA (miRNA), circular (circRNA) by sequence, significant differential (DE) these types selected for further...
The ticks feed large amount of blood from their hosts and transmit pathogens to the victims. salivary gland plays an important role in feeding. When female are near engorgement, gradually loses its functions begins rapidly degenerate. In this study, data-independent acquisition quantitative proteomics was used study changes phosphorylation modification proteins during degeneration <i>Haemaphysalis longicornis</i>. 400 phosphorylated 850 sites were identified. Trough RNA...