A5100434512- Hematopoietic Stem Cell Transplantation
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Mesenchymal stem cell research
- Blood groups and transfusion
- Fungal Infections and Studies
- Acute Myeloid Leukemia Research
- Antifungal resistance and susceptibility
- Cancer Cells and Metastasis
- Platelet Disorders and Treatments
- Erythrocyte Function and Pathophysiology
- Immunotherapy and Immune Responses
- MicroRNA in disease regulation
- Dermatology and Skin Diseases
- Childhood Cancer Survivors' Quality of Life
- Mast cells and histamine
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Iron Metabolism and Disorders
- Renal Diseases and Glomerulopathies
- Neutropenia and Cancer Infections
- Healthcare and Venom Research
- Blood properties and coagulation
- Diagnosis and Treatment of Venous Diseases
- Lymphoma Diagnosis and Treatment
- Fibroblast Growth Factor Research
First Affiliated Hospital Zhejiang University
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2022
Institute of Hematology & Blood Diseases Hospital
2014-2022
Union Hospital
2020
Huazhong University of Science and Technology
2020
Charité - Universitätsmedizin Berlin
2020
Humboldt-Universität zu Berlin
2020
Freie Universität Berlin
2020
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2020
Xiangya Hospital Central South University
2020
Transforming growth factor β1 (TGF-β1) plays a role in the maintenance of quiescent hematopoietic stem cells (HSCs) vivo. We asked whether TGF-β1 controls cell cycle status HSCs vitro to enhance reconstitution activity. To examine effect on HSC function, we used an culture system which single divide with retention their short- and long-term ability. Extensive single-cell analyses showed that, regardless its concentration, slowed down progression but consequently suppressed self-renewal...
Ferritin is a hepatic protein that plays vital roles in diagnosing and predicting diseases, but its potential coronavirus disease 2019 (COVID-19) remains unknown.We collected clinical records from 79 COVID-19 patients at Wuhan Union hospital (China). Spearman's correlation analysis, receiver operating characteristic (ROC) curve Kaplan-Meier survival curves were employed.Patients with elevated ferritin levels had higher incidence of severity illness (50.0 vs 2.9%) liver injury (52.3 20.0%)...
Rare but critical bleeding events in primary immune thrombocytopenia (ITP) present life-threatening complications patients with ITP, which severely affect their prognosis, quality of life, and treatment decisions. Although several studies have investigated the risk factors related to large sample size data, consistent definitions, large-scale multicenter findings, prediction models for ITP are unavailable. For first time, this study, we applied newly proposed criteria by International...
IgA nephropathy (IgAN) is one of the most common forms idiopathic glomerular diseases and might lead to end-stage kidney disease. Accurate non-invasive biomarkers for early diagnosis are required intervention consequent therapy IgAN patients. Because variance in disease incidence predisposing genes has been detected among different ethnicities, ethnicity factor should be considered biomarker discovery. The differences protein profiles pathological mechanisms patients Uygur need clearly...
Liver injury associated with acute graft-versus-host disease (aGVHD) is a frequent and severe complication of hematopoietic stem cell transplantation remains major cause transplant-related mortality. Bone marrow-derived mesenchymal cells (BM-MSCs) has been proposed as potential therapeutic approach for aGVHD. However, the effects are not always achieved. In this study, we genetically engineered C57BL/6 mouse BM-MSCs AKT1 gene tested whether AKT1-MSCs was superior to control MSCs (Null-MSCs)...
The cell of origin, defined as the normal in which transformation event first occurs, is poorly identified leukemia, despite its importance understanding leukemogenesis and improving leukemia therapy. Although hematopoietic stem cells (HSCs) progenitor (HPCs) were used for models, whether their self-renewal differentiation potentials influence initiation development largely unknown. In this study, 2 distinct types HSCs (HSC1 [CD150+CD41-CD34-Lineage-Sca-1+c-Kit+ cells] HSC2...
Hematopoietic stem cells (HSCs) self-renew or differentiate through division. Cytokines are essential for inducing HSC division, but the optimal cytokine combination to control self-renewal of in vitro remains unclear. In this study, we compared effects interleukin-12 (IL-12) and thrombopoietin (TPO) with cell factor (SCF) on HSCs. Single-cell assays were used overcome heterogeneity issue HSCs, serum-free conditions newly established permit reproduction data. single-cell cultures,...
Abstract Introduction Abnormally activated complement system induces erythrolysis in a part of autoimmune hemolytic anemia (AIHA) patients. However, the alterations serum levels these patients are seldom reported. In this study, we aimed to evaluate features AIHA according different clinical and laboratory characteristics find relationships between hemolysis‐associated indexes. Methods A retrospective analysis 146 was performed, C3 C4 were compared control subjects with subtypes....
Aim: Posaconazole (POS) is an extended-spectrum triazole approved for treatment of refractory invasive fungal disease. Outcome analysis POS salvage therapy great clinical significance. Methods: We retrospectively reviewed data 113 patients who received oral suspension as between December 2013 and May 2018. Results: Cumulative success rate at 12 weeks was 53.1% (60/113) with a rapid increase within the first 3–4 plateau 6 after initiation. Multivariate logistic regression showed that...
Aim: Invasive fungal disease (IFD) is a significant cause of morbidity and mortality in hematopoietic stem cell transplantation (HSCT) patients. This study reports real-world efficacy safety posaconazole (POS) HSCT recipients with IFD. Patients & methods: We performed retrospective to investigate the POS oral suspension 45 patients IFD from December 2013 2016. Results: The success rate at 12 weeks after treatment was 57.8%. Multivariate logistic regression analysis showed that persistent...
Mucosal-associated invariant T (MAIT) cells are innate-like cells, some studies have reported that the number of circulating MAIT reduced in patients with acute graft-versus-host-disease (aGVHD) development. However, role donor on aGVHD development and subsequent functional change still remain unclear.The study recruited 86 hematological malignancies who underwent allogeneic hematopoietic cell transplantation (HCT) from May 1, 2018 to June 30, 2019. their subset, cytokine levels were...
To explore clinical features and laboratory data of glucose-6-phosphate dehydrogenase（G6PD）deficiency to investigate the relationship between them.Clinical 43 patients with G6PD deficiency was analyzed, statistical method applied data.Among patients，neonatal jaundice occurred as first symptom in 10 cases，while acute hemolytic anemia 23 cases. The major symptoms included icteric skin and/or sclera，dark urine，fever，gastrointestinal symptoms，fatigue lethargy. Symptoms 26 were caused by obvious...
To evaluate the efficacy of alternative donor allogeneic hematopoietic stem cell transplantation (AD allo-HSCT) in treatment severe aplastic anemia (SAA).Retrospective analysis clinical data 19 SAA patients received AD allo-HSCT from May 2003 to December 2012. Of them, 12 haploidentical HSCT (haplo-HSCT), 7 unrelated transplantation. The conditioning regimen was CY+ATG+Flu±Ara-C±Bu/Mel, GVHD preventing MMF+MTX+CSA/FK506; median reinfusion quantity CD34+ 3.10(2.11-4.38)×10⁶/kg allo-BMT and...
To compare the outcomes of adult patients with acute lymphoblastic leukemia (ALL) who underwent autologous hematopoietic stem cell transplantation (auto-HSCT) and allogeneic (allo-HSCT).From Jan 2007 to Dec 2010, 106 ALL were retrospectively divided into two groups, 50 in auto-HSCT group 56 allo-HSCT group. Auto-HSCT included 21 high-risk, 46 CR1 4 cases CR2. All had negative minimal residual disease (MRD) prior HSCT. Allo-HSCT 44 high risk, 51 5 CR2, 15 positive MRD before allo-HSCT....
To investigate the effect of microRNA-382 (miR-382) on biological properties human umbilical cord-derived mesenchymal stem cells (hUC-MSC).The mimics and inhibitor miR-382 were transfected into hUC-MSC with lipo2000. Inverted microscopy was used to observe morphology change hUC-MSC. The proliferation detected by CCK-8. Oil red O alizarin staining applied assess adipogenic osteogenic differentiation Cetylpyridinium chloride quantitative analysis differentiation. expression Runx2 some...
To investigate the clinical features and laboratory characteristics of primary autoimmune hemolytic anemia (AIHA) patients with negative results direct antiglobulin test (DAT) by tube but positive microcolumn gel assay, in order to provide references for diagnosis these patients.59 diagnosed AIHA our hospital from January 2015 December 2020 were retrospectively analyzed. According cases divided into 3 groups, each group compared.The grouped as follows: Group I, both methods DAT (n=5); II,...
To identify the role of serum cytokine levels prior allogeneic hematopoietic stem cell trans-plantation (allo-HSCT) in outcome severe aplastic anemia (SAA) patients received allo-HSCT treatment.The clinical data 117 SAA were enrolled this study. The overall survival (OS), graft versus host disease (GVHD) incidence and relationship cytokines with OS major transplantation complications retrospectively analyzed.The study included 78(66.7%) cases HSCT matched sibling donors (MSD), 12(10.2%)...
Abstract Background To establish prediction models for venous thromboembolism (VTE) in non-oncological urological inpatients. Methods A retrospective analysis of 1453 inpatients was carried out and the risk factors VTE had been clarified our previous studies. Results Risk included following 5 factors: presence (X 1 ), anticoagulants or anti-platelet agents treatment before admission 2 D-dimer value (≥ 0.89 µg/ml, X 3 lower extremity swelling 4 chest symptoms ). The logistic regression model...