Potentially nephrotoxic drugs play an important role in acute kidney injury (AKI) children. In the previous pharmacovigilance study, we found a statistical correlation between diazepam and AKI children, but causality needs to be further verified. An observational cohort study was conducted investigate association exposure risk of hospitalized The exposed group received while control did not. outcome accordance with Kidney Disease Improving Global Outcomes (KDIGO) guidelines. Logistic...

Abstract Creating secondary nanostructures from fundamental building blocks with simultaneous high loading capacity and well‐controlled size/uniformity, is highly desired for nanoscale synergism integration of functional units. Here a novel strategy reported hydrophobic quantum dots (QDs) assembley porous templates, to form pitaya‐type fluorescent silica colloids densely packed intact QDs throughout the matrix. The mercapto‐terminated dendritic spheres accessible central–radial pores...

Near-infrared electrochemiluminescence (NIR ECL) from quantum dots (QDs) has aroused particular attention. However, whether it is possible to achieve NIR ECL sensing remained an open question. In this article, we reported a immunosensor with amplification techniques for ultrasensitive and selective determination of biomarker. platform, NIR-emitting CdTe/CdS core(small)/shell(thick) QDs were first selected as emitters. The nanoprobe (SiO(2)-QD-Ab2) was designed by covalent assembly goat...

Platinum nanotubes (PtNTs) exhibiting high porosity were constructed by sacrificing the exterior of tellurium nanowires (TeNWs) and disintegrating inner part spontaneously in aqueous solution at room temperature, which Kirkendall effect may play an important role. The present PtNTs exhibited intrinsic peroxidase-like activity presence H2O2.

Bright and stable CuInS2/ZnS@SiO2 nanoparticles with near-infrared (NIR) emission were competently prepared by incorporating the as-prepared hydrophobic CuInS2/ZnS quantum dots (QDs) directly into lipophilic silane micelles subsequently an exterior silica shell was formed. The obtained homogeneously comprised both single-core multicore remarkable QDs, while thickness could be controlled to within 5–10 nm their overall size 17–25 nm. Also, functionalized QDs encapsulated in spheres, expedited...

Antibiotics abuse has caused various problems threatening human health and ecological environment. Monitoring antibiotics residual levels is of great significance, yet still challenging for quantitative point-of-need testing with high-sensitivity visual capability. Here we developed a competitive lateral flow immunoassay (CLFIA) platform flexible readout enrofloxacin (ENR), regularly added antibiotic. To overcome the limitation low sensitivity traditional colloidal gold-based CLFIA,...

Immunological detection of small molecules in a point-of-care (POC) format is great significance yet remains challenging for accurate visual discrimination and quantitative analysis. Here, we report novel hue recognition competitive fluorescent lateral flow immunoassay (HCLFIA) strip that allows both aflatoxin M1 (AFM1). The HCLFIA works on the basis ratiometric change emission, arising from overlap fluorescence signals two nanocomposites tagged with probe antibodies coated antigens. A...

Abstract The hue‐recognition based point‐of‐care diagnosis favorites both human visual perception and imaging analysis with portable terminals. Semiconductor nanoplatelets (NPLs) as an emerging narrow‐emissive fluorophore particularly suit above color‐purity desired diagnosis, but are hindered by their intrinsic hydrophobicity difficulty in controlled assembly. Here the host‐guest assembling of hydrophobic NPLs developed within 3D porous space dendritic templates, stepwise surface...

Integrating multiple discrete functionalities into hollow-mesoporous architecture with distinctive electronic/magnetic property is of particular interest for building multifunctional drug carriers complementary theranostic modalities. In this article, the "non-contact" incorporation gold nanorod (GNR) porous magnetic nanoshell achieved via yolk–shell structure, which was intrinsically different from previous direct chemical or heterogeneous conjugation two components. The highly preserved...

A surfactant/swelling-agent pair suitable for templating a variety of well-defined large-pore nanoporous silicas was identified. The includes poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide), PEO-PPO-PEO, block copolymer surfactant (Pluronic F127, EO106PO70EO106) with large fraction long hydrophilic PEO blocks and swelling agent (toluene) that strongly solubilizes in micelles the PEO-PPO-PEO family. Such combination affords micellar templates both spherical cylindrical...

Fluorescence barcoding based on nanoparticles provides many advantages for multiparameter imaging. However, creating different concentration-independent codes without mixing various and by using single-wavelength excitation emission multiplexed cellular imaging is extremely challenging. Herein, we report the development of quantum dots (QDs) with two SiO

Lateral flow immunoassay (LFIA), as a prominent point-of-care (POC) test platform, has been extensively adopted for rapid, on-site, and facile diagnosis of pathogen infections disease biomarkers. Exploring novel structured optical labels LFIA with amplified signal complementary detection modes favors the sensitive flexible POC diagnosis. Here, bimodal both colorimetric fluorescent readout were fabricated via layered sequential assembly strategy based on affinity templates hydrophobic...

Semiconductor quantum dots (QDs) are the most versatile fluorophores for Förster resonance energy transfer (FRET) because they can function as both donors and acceptors a multitude of fluorophores. However, complete understanding multidonor–multiacceptor FRET networks on QDs their full employment into advanced fluorescence sensing imaging have not been accomplished. Here, we provide holistic photophysical analysis such multidonor-QD-multiacceptor systems using time-resolved steady-state...

Exploring signal amplification strategies to enhance the sensitivity of lateral flow immunoassay (LFIA) is great significance for point-of-care (POC) testing low-concentrated targets in field vitro diagnostics. Here, a highly-sensitive LFIA platform using compact and hierarchical magneto-fluorescent assemblies as both target-enrichment substrates optical sensing labels demonstrated. The large-pored dendritic templates are utilized high-density incorporation superparamagnetic iron oxide...

Abstract We report the development of a highly sensitive ratiometric fluorescent lateral flow immunoassay (RFLFIA) strip for rapid and accurate detection acute myocardial infarction biomarker, namely heart‐type fatty acid binding protein (H‐FABP). The RFLFIA works in terms change fluorescence signal, arising from blending emitted by two composite nanostructures conjugated to capture probe antibodies inner filter effect gold nanoparticles. In conjunction with using custom smartphone‐based...

Although the competitive lateral flow immunoassay (CLFIA) using gold nanoparticles (AuNPs) as labels has been widely adopted for rapid detection of small molecules, its sensitivity is often constrained by insufficient colorimetric signal produced conventional AuNPs labels. Herein, we introduce a new type intensified label, denoted SAAS, which engineered integrating gold-silver alloy (Au-Ag NPs) within dendritic silica scaffold. These pitaya-type nanohybrids combine advantages amplified molar...

Abstract Fluorescent lateral flow immunoassays (FLFIA) is a well‐established rapid detection technique for quantitative analysis. However, achieving accurate analysis of biomarkers at the pg mL −1 level using FLFIA still poses challenges. Herein, an ultrasensitive platform reported utilizing kiwi‐type magneto‐fluorescent silica nanohybrid (designated as MFS) that serves both target‐enrichment substrate and optical signal enhancement label. The spatially‐layered architecture comprises Fe 3 O...

Ultralarge-pore FDU-12 (ULP-FDU-12) silicas with face-centered cubic structures (Fm3m symmetry) of spherical mesopores were synthesized at low initial temperature (∼14 °C) using commercially available PEO-PPO-PEO triblock copolymer Pluronic F127 as a micellar template and xylene micelle expander. Xylene was selected on the basis its predicted higher swelling ability for surfactant micelles in comparison to 1,3,5-trimethylbenzene that used previously obtain large-pore FDU-12. The optimization...

In this work, we show that precise control of the pore size and functionality in an ultramicroporous metal-organic framework platform can finely tune adsorption selectivity between acetylene carbon dioxide at will.