A5108256564- Nanoplatforms for cancer theranostics
- Photoacoustic and Ultrasonic Imaging
- Nanoparticle-Based Drug Delivery
- Advanced biosensing and bioanalysis techniques
- Extracellular vesicles in disease
- Photodynamic Therapy Research Studies
- Advanced Nanomaterials in Catalysis
- Quantum Dots Synthesis And Properties
- Luminescence and Fluorescent Materials
- Ultrasound and Hyperthermia Applications
- Nanocluster Synthesis and Applications
- RNA Interference and Gene Delivery
- Gold and Silver Nanoparticles Synthesis and Applications
- Chalcogenide Semiconductor Thin Films
- Biosensors and Analytical Detection
- Carbon and Quantum Dots Applications
- Ultrasound Imaging and Elastography
- Thermography and Photoacoustic Techniques
- Cancer, Hypoxia, and Metabolism
- Click Chemistry and Applications
- Supramolecular Self-Assembly in Materials
- Radiation Detection and Scintillator Technologies
- Graphene and Nanomaterials Applications
- Cancer Cells and Metastasis
- Advanced Radiotherapy Techniques
Shenzhen Institutes of Advanced Technology
2016-2025
Chinese Academy of Sciences
2016-2025
Bio-Medical Science (South Korea)
2021
Huazhong University of Science and Technology
2021
Academia Sinica
2019
Micro Materials (United Kingdom)
2019
Shaanxi Normal University
2018
China XD Group (China)
2018
Institute for Biomedicine
2014-2017
Shenzhen University
2014-2016
A combination of chemotherapy and photothermal therapy has emerged as a promising strategy for cancer therapy. To ensure the chemotherapeutic drug agent could be simultaneously delivered to tumor region exert their synergistic effect, safe efficient delivery system is highly desirable. Herein, we fabricated doxorubicin (DOX) indocyanine green (ICG) loaded poly(lactic-co-glycolic acid) (PLGA)–lecithin–polyethylene glycol (PEG) nanoparticles (DINPs) using single-step sonication method. The...
Phototherapy, including photodynamic therapy (PDT) and photothermal (PTT), is a light-activated local treatment modality that under intensive preclinical clinical investigations for cancer. To enhance the efficiency of phototherapy reduce light-associated side effects, it highly desirable to improve drug accumulation precision guided efficient conversion absorbed light energy reactive oxygen species (ROS) hyperthermia. In present study, programmed assembly strategy was developed preparation...
Abstract Precise diagnostics are of significant importance to the optimal treatment outcomes patients bearing brain tumors. NIR‐II fluorescence imaging holds great promise for brain‐tumor with deep penetration and high sensitivity. This requires development organic fluorescent agents quantum yield (QY), which is difficult achieve. Herein, design synthesis a new molecule aggregation‐induced‐emission (AIE) characteristics reported orthotopic imaging. Encapsulation in polymer matrix yields AIE...
Abstract Theranostics is a concept that integrated imaging and therapy. As an emerging field, it embraces multiple techniques to arrive at individualized treatment purpose. Indocyanine green (ICG) near infrared dye has been approved by Food Drug Administration (FDA) in USA for the use indicator-dilution studies humans. ICG nanoparticles (NPs) have attracted much attention its potential applications cancer theranostics. This review focuses on preparation, application of NPs vivo (fluorescent...
Diagnostics of cerebrovascular structures and microscopic tumors with intact blood-brain barrier (BBB) significantly contributes to timely treatment patients bearing neurological diseases. Dual NIR-II fluorescence photoacoustic imaging (PAI) is expected offer powerful strength, including good spatiotemporal resolution, deep penetration, large signal-to-background ratio (SBR) for precise brain diagnostics. Herein, biocompatible photostable conjugated polymer nanoparticles (CP NPs) are...
Abstract Brain tumor is one of the most lethal cancers owing to existence blood–brain barrier and as well lack highly effective brain treatment paradigms. Herein, cyclo(Arg‐Gly‐Asp‐D‐Phe‐Lys(mpa)) decorated biocompatible photostable conjugated polymer nanoparticles with strong absorption in second near‐infrared (NIR‐II) window are developed for precise photoacoustic imaging spatiotemporal photothermal therapy through scalp skull. Evidenced by higher efficiency penetrate skull 1064 nm laser...
Advances in phototheranostics revolutionized glioma intraoperative fluorescence imaging and phototherapy. However, the lack of desired active targeting agents for crossing blood-brain barrier (BBB) significantly compromises theranostic efficacy. In this study, biomimetic proteolipid nanoparticles (NPs) with U.S. Food Drug Administration (FDA)-approved indocyanine green (ICG) were constructed to allow imaging, tumor margin detection, phototherapy orthotopic mice. By embedding cell membrane...
Conjugated polymer nanoparticles (CP NPs) are emerging candidates of "all-in-one" theranostic nanoplatforms with dual photoacoustic imaging (PA) and photothermal therapy (PTT) functions. So far, very limited molecular design guidelines have been developed for achieving CPs highly efficient PA PTT performance. Herein, by designing CP1, CP2, CP3 using different electron acceptors (A) a planar donor (D), we demonstrate how the D-A strength affects their absorption, emission, extinction...
Photoacoustic (PA) imaging and photothermal therapy (PTT) as light-induced theranostic platforms have been attracted much attention in recent years. However, the development of highly efficient integrated phototheranostic nanoagents for amplifying PA PTT treatments poses great challenges. Here, we report a novel nanoagent using indocyanine green-loaded polydopamine-reduced graphene oxide nanocomposites (ICG-PDA-rGO) with effects cancer theranostics. The results demonstrate that PDA layer...
High performance X-ray detector with ultra-high spatial and temporal resolution are crucial for biomedical imaging. This study reports a dynamic direct-conversion CMOS assembled screen-printed CsPbBr
In this paper, we report a new homogeneous assay for rapid, highly selective and sensitive detection of Hg2+ in aqueous solution based on the induced photoluminescence (PL) quenching BSA-modified gold nanoclusters (BSA-Au NCs). There was linear correlation between expression (I0 − I)/I0 concentrations over ranges 0.4–43.2 μM, corresponding limit (LOD) 80 nM. The relative standard deviation 5 replicate measurements 1.4% 1.0 × 10−5 mol L−1 Hg2+. Moreover, method has excellent selectivity metal...
Abstract Photodynamic therapy has been increasingly applied in clinical cancer treatments. However, native hypoxic tumoural microenvironment and lacking oxygen supply are the major barriers hindering photodynamic reactions. To solve this problem, we have developed biomimetic artificial red cells by loading complexes of oxygen-carrier (hemoglobin) photosensitizer (indocyanine green) for boosted strategy. Such nanosystem provides a coupling structure with stable self-oxygen acting as an ideal...
Photoacoustic (PA) imaging, as a fast growing technology that combines the high contrast of light and large penetration depth ultrasound, has demonstrated great potential for molecular imaging cancer. However, PA orthotopic brain tumors is still challenging, partially due to limited options insufficient sensitivity available probes. Here, direct formation single‐layer (S‐MoS 2 ), few‐layer (F‐MoS multi‐layer (M‐MoS ) nanosheets by albumin‐assisted exfoliation without further surface...
Multi-modal imaging-guided cancer photothermal therapy (PTT) with advanced theranostic nanoagents can efficiently improve therapeutic efficacy and reduce treatment side effects. Herein, we have developed a nanoagent based on indocyanine green (ICG)-loaded polydopamine (PDA)-iron ions coordination nanoparticles (PDA-Fe3+-ICG NPs), which are used for photoacoustic (PA) magnetic resonance (MR) dual-modal PTT treatments. In this nanoplatform, ICG molecules, the U.S. Food Drug Administration...
NIR II conjugated polymer nanoparticles with good biocompatibility, excellent photoacoustic stability and high imaging contrast are formulated, which allows highly efficient of orthotopic brain tumors a signal/background ratio penetration depth.
We synthesized a new class of mutifunctional multidentate-imidazole polymer ligands by one-step reaction to produce conjugation-ready QDs with great stability and compact size. Furthermore, combined strain-promoted click chemistry, we developed general strategy for efficient labeling living-viruses QD probes.
Burn infection is one of the commonest causes death in severely burned patients. Developing multifunctional biological nanomaterials has a great significance for comprehensive treatment burn infection. In this paper, we developed hydrogel-based nanodelivery system with antibacterial activity and skin regeneration function, which was used photodynamic antimicrobial chemotherapy (PACT) burns. The mainly composed porphyrin photosensitizer sinoporphyrin sodium (DVDMS) poly(lactic-co-glycolic...
Nanoprobes with enzyme-like properties attracted a growing interest in early screening and diagnosis of cancer.To achieve high accuracy specificity tumor detection, the design preparation enzyme mimetic nanoprobes activity, targeting excellent luminescence property is highly desirable.Herein, we described novel kind fluorescence nanoprobe based on folate receptor-targeting Au nanoclusters.The exhibited stability, low cytotoxicity, activity.We demonstrated that could be used for tissues...
Abstract Copper enrichment in the brain is highly related to Alzheimer's disease (AD) pathogenesis, but vivo tracing of Cu 2+ by imaging techniques still a great challenge. In this work, we developed series activatable photoacoustic (PA) probes with low molecular weights (less than 438 Da), RPS1 – RPS4 , which can specifically chelate form radicals turn‐on PA signals near‐infrared (NIR) region. Introducing electron‐donating group N ‐dimethylaniline into probe was found significantly enhance...