A5090152485- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Ultrasound and Hyperthermia Applications
- Liver Disease and Transplantation
- Photoacoustic and Ultrasonic Imaging
- Hepatitis B Virus Studies
- Organ Transplantation Techniques and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Nanoplatforms for cancer theranostics
- MRI in cancer diagnosis
- Gallbladder and Bile Duct Disorders
- Ultrasound Imaging and Elastography
- Cardiovascular Health and Disease Prevention
- Transplantation: Methods and Outcomes
- Cerebrovascular and Carotid Artery Diseases
- Animal Virus Infections Studies
- Radiomics and Machine Learning in Medical Imaging
- Cardiovascular Disease and Adiposity
- Hepatitis C virus research
- Liver Diseases and Immunity
- Pediatric Hepatobiliary Diseases and Treatments
- Nanoparticle-Based Drug Delivery
- Thermography and Photoacoustic Techniques
- Liver physiology and pathology
- Viral gastroenteritis research and epidemiology
Sun Yat-sen University
2015-2024
Third Affiliated Hospital of Sun Yat-sen University
2015-2024
Zhongshan Hospital
2010-2024
Tongren Hospital
2024
Harbin Medical University
2024
Tianjin Third Central Hospital
2024
Chinese PLA General Hospital
2023-2024
Tianjin Medical University
2024
Huashan Hospital
2024
Shanghai Jiao Tong University
2024
We aimed to evaluate the performance of newly developed deep learning Radiomics elastography (DLRE) for assessing liver fibrosis stages. DLRE adopts radiomic strategy quantitative analysis heterogeneity in two-dimensional shear wave (2D-SWE) images.A prospective multicentre study was conducted assess its accuracy patients with chronic hepatitis B, comparison 2D-SWE, aspartate transaminase-to-platelet ratio index and based on four factors, by using biopsy as reference standard. Its robustness...
Abstract: The fabrication and initial applications of nanobubbles (NBs) have shown promising results in recent years. A small particle size is a basic requirement for ultrasound contrast-enhanced agents that penetrate tumor blood vessel pores to allow targeted imaging therapy. However, the nanoscale particles used has disadvantage weakening ability clinical diagnostic ultrasound. In this work, we fabricated lipid NBs agent evaluated its passive targeting vivo. showed were (436.8 ± 5.7 nm),...
To evaluate the individual and combined performances of two-dimensional (2D) shear-wave elastography (SWE) conventional ultrasonography (US) in assessing liver fibrosis cirrhosis to determine when 2D SWE should be added routine US.This prospective study was approved by institutional ethics committee, patients provided written informed consent. Between April 2012 March 2013, US examinations were performed 198 (mean age, 37.7 years; age range, 18-67 years) with chronic disease. Liver biopsy...
Among medical imaging modalities available in the clinic, ultrasonography is most convenient, inexpensive, ionizing-radiation-free, and common. Micrometer-size perfluorocarbon bubbles have been used as efficient contrast for intravascular ultrasonography, but they are too big tumor penetration. Nanodroplets (250–1000 nm) encapsulating both drug an ultrasound-triggered release delivery platform against cancer, generally not useful a agent. The present study aims to develop type of...
Abstract Non-invasive detection of microvascular alterations in deep tissues vivo provides critical information for clinical diagnosis and evaluation a broad-spectrum pathologies. Recently, the emergence super-resolution ultrasound localization microscopy (ULM) offers new possibilities imaging microvasculature at capillary level. Currently, utility ULM on scanners is hindered by technical limitations, such as long data acquisition time, high microbubble (MB) concentration, compromised...
To evaluate the imaging findings of biliary hamartomas (von Meyenburg complexes, VMCs) and discuss differential diagnosis with other related diseases.Imaging on ultrasonography (US), computed tomography (CT), magnetic resonance (MRI), MR cholangiopancreatography (MRCP)and hepatobiliary scintigraphy were retrospectively analyzed in six patients.On ultrasound images, five cases showed multiple small hyper- hypo-echoic lesions comet-tail echoes, especially when magnified by US usage zoom...
We developed a linear ultrasound array-based real-time photoacoustic imaging system with compact coaxial excitation handheld probe for guiding sentinel lymph node (SLN) needle biopsy. Compared previous studies, our and have the following advantages: (1) is quite user-friendly; (2) laser illumination ultrasonic detection are achieved coaxially, enabling high signal-to-noise ratio; (3) GPU-based image reconstruction enables displaying at frame rate of 20 Hz. With probe, clear visualization SLN...
Purpose To investigate the diagnostic performance of two-dimensional (2D) shear-wave elastography (SWE) in chronic hepatitis B. Materials and Methods This prospective multicenter study from January 2015 to 2016 was conducted at 12 hospitals included 654 participants with B who had undergone liver biopsy 2D SWE examination. Participants were divided into infection groups. The compared aspartate amino transferase–to-platelet ratio index (APRI), Fibrosis-4 (FIB-4), transient (TE) by using a...
Multimodality imaging based on multifunctional nanocomposites holds great promise to fundamentally augment the capability of biomedical imaging. Specifically, photoacoustic and fluorescence dual-modality is gaining much interest because their non-invasiveness complementary nature two modalities in terms resolution, depth, sensitivity, speed. Herein, using a green facile method, we synthesize indocyanine (ICG) loaded, polyethylene glycol (PEG)ylated, reduced nano-graphene oxide nanocomposite...
Endoscopy is an essential clinical tool for the diagnosis of gastrointestinal (GI) tract cancer. A photoacoustic system that elegantly combines optical and ultrasound endoscopy advantages by providing high‐sensitivity functional information large imaging depth a potentially powerful GI imaging. Recently, several endoscopic systems have been proposed developed. However, relatively size rigid length catheter make it difficult to translate them into wide applications; while existing small...
Monitoring the changes in tumor vascularity is important for anti-angiogenic therapy assessment with therapeutic implications. However, monitoring quite challenging due to lack of appropriate imaging techniques. Here, we describe a non-invasive technique using optical-resolution photoacoustic microscopy (OR-PAM) track vascular prostate cancer treated an agent, DC101, on mouse ear xenograft model. Approximately 1–3 days after initial therapy, OR-PAM detected such as reduced vessel tortuosity,...
Photodynamic therapy (PDT) holds promise for focal of prostate cancer (PCa).However, the therapeutic efficacy needs improvement, and further development PDT PCa has challenges, including uncertainty photosensitizers (PSs) accumulation at tumor site difficulty in visualizing lesions using conventional ultrasound (US) imaging.We have developed novel porphyrin-grafted lipid (PGL) microbubbles (MBs; PGL-MBs) propose a strategy to integrate PGL-MBs with US imaging address these limitations...
Objective Liver stiffness measurement (LSM) is a tool used to screen for significant fibrosis and portal hypertension. The aim of this retrospective multicentre study was develop an easy using LSM clinical outcomes in advanced chronic liver disease (ACLD) patients. Design This international cohort included derivation ACLD patient with valid two-dimensional shear wave elastography (2D-SWE) results. Clinical laboratory parameters at baseline during follow-up were recorded. by transient (TE)...
Background Little is known about the benefits of use dispersion slope (DS) as a viscosity-related parameter derived from two-dimensional (2D) shear-wave elastography (SWE) in stratification hepatic pathologic stages. Purpose To evaluate whether DS an additional can improve diagnostic performance detecting liver necroinflammation, fibrosis, and steatosis. Materials Methods In this prospective study, consecutive participants with chronic disease who underwent biopsy 2D SWE were recruited...