A5060911926- Lymphoma Diagnosis and Treatment
- RNA modifications and cancer
- Cancer-related gene regulation
- Autophagy in Disease and Therapy
- Kidney Stones and Urolithiasis Treatments
- Cancer therapeutics and mechanisms
- Lung Cancer Research Studies
- Cancer-related molecular mechanisms research
- DNA Repair Mechanisms
- Pediatric Urology and Nephrology Studies
- Chronic Lymphocytic Leukemia Research
- Lung Cancer Treatments and Mutations
- RNA Research and Splicing
- Assisted Reproductive Technology and Twin Pregnancy
- Ovarian function and disorders
- Pelvic floor disorders treatments
- Head and Neck Cancer Studies
- Hematopoietic Stem Cell Transplantation
- Reproductive Biology and Fertility
- Radiomics and Machine Learning in Medical Imaging
- RNA and protein synthesis mechanisms
- PARP inhibition in cancer therapy
- Acute Lymphoblastic Leukemia research
- Cancer Treatment and Pharmacology
- MicroRNA in disease regulation
First Affiliated Hospital of Jinan University
2024
Naval University of Engineering
2024
First Affiliated Hospital of Xiamen University
2020-2024
National Health and Family Planning Commission
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Peking Union Medical College Hospital
2024
Guangdong Provincial People's Hospital
2024
Fujian Medical University
2019-2023
First Affiliated Hospital of Fujian Medical University
2023
Pfizer (United States)
2023
Abstract Background As the most abundant epigenetic modification on mRNAs and long non‐coding RNAs, N6‐methyladenosine (m6A) extensively exists in mammalian cells. Controlled by writers (methyltransferases), readers (signal transducers), erasers (demethylases), m6A influences mRNA structure, maturation, stability, thus negatively regulating protein expression a post‐translational manner. Nevertheless, current understanding of m6A's roles tumorigenesis, especially gastric cancer (GC) remains...
Autophagy, a process for degrading intracellular substances to maintain basal metabolic turnover, is known be perturbed in gastric cancer. Programmed cell death-1 (PD-1) with its ligand (PD-L1) are important immune checkpoint proteins and their regulation by autophagy has been reported mouse melanoma human ovarian Here, we explored the interplay between PD1/PD-L1 axis cancer.The expression of PD-L1 cancer cells was detected Western blot flow cytometry analysis. The effect inhibition on...
Long non-coding RNAs (lncRNAs) play critical roles in tumorigenesis and progression of colorectal cancer (CRC). However, functions most lncRNAs CRC their molecular mechanisms remain uncharacterized. Here we found that lncRNA ITGB8-AS1 was highly expressed CRC. Knockdown suppressed cell proliferation, colony formation, tumor growth CRC, suggesting oncogenic ITGB8-AS1. Transcriptomic analysis followed by KEGG revealed focal adhesion signaling the significantly enriched pathway for genes...
Abstract Paclitaxel (PTX) is widely used in the front-line chemotherapy for gastric cancer (GC), but resistance limits its use. Due to lack of proper models, mechanisms underlying PTX GC were not well studied. Using established PTX-resistant cell sublines HGC-27R, we first time integrated biological traits and molecular GC. Data revealed that cells characterized by microtubular disorders, an EMT phenotype, reduced responses antimitotic drugs, apoptosis (marked upregulated β-tubulin III,...
Targeting poly ADP-ribose polymerase (PARP) has been recently identified as a promising option against gastric cancer (GC). However, PARP inhibitors alone achieve limited efficacy. Combination strategies, especially with homologous recombination (HR) impairment, are of great hope to optimize inhibitor's efficacy and expand target populations but remains largely unknown. Herein, we investigated whether WEE1/ Polo-like kinase 1 (PLK1) dual inhibitor AZD1775 reported impair HR augmented...
Abstract Esophageal squamous cell carcinoma (ESCC) is a frequently diagnosed and deadly malignancy with few standard therapeutic options. Camptothecins are considered one of the most promising antitumor drugs. A modified lipophilic analog, gimatecan, was synthesized as novel oral camptothecin showed impressive effects in various tumors, but its efficacy mechanisms ESCC remain unclear. This study investigated gimatecan ECSS both vitro vivo. Using lines, line-derived xenografts patient-derived...
Members of the aaRS (aminoacyl-tRNA synthetase) family are proteins controlling aminoacylation process, in which YARS (tyrosyl-tRNA catalyzes binding tyrosine to its cognate tRNA and plays an important role basic biosynthesis. Several studies have demonstrated association between mutation certain developmental abnormalities/diseases, yet YARS's linkage with cancer remains uncategorized. In this study, by combining silico, vitro, vivo studies, we explored expressions functions gastric (GC).We...
Cervical cancer is a fatal burden for women. Circular RNAs (circRNAs) are important regulators in development. Our study aimed to investigate the function and action mechanism of novel circRNA, circ_0084927, cervical cancer.The expression miR-142-3p ADP-ribosylation factor-like protein 2 (ARL2) mRNA was measured by quantitative real-time polymerase chain reaction (qRT-PCR). For functional analyses, cell proliferation assessed using counting kit-8 (CCK-8) assay. Cell cycle distribution...
Based on the mechanisms by which Wee1 inhibitor and cisplatin played their own role, a promising strategy of combined with was proposed, investigated in gastric cancer (GC). Either AZD1775 or alone had certain inhibitory effect vitro cell proliferation; however, more significant when vivo. The underlying unveiled that increased DNA damage indicated γH2AX protein, as well augmented apoptosis upregulated proapoptotic proteins, responsible for plus cisplatin. Moreover, compared to any single...
Colorectal cancer (CRC) is the second most common cause of cancer-related death worldwide, and well known for its strong invasiveness, rapid recurrence poor prognosis. Long non-coding RNAs (lncRNAs) have been shown to be involved in development variety types cancers, including colorectal cancer. Here, through transcriptomic analysis functional screening, we reported that lncRNA LUCRC (LncRNA Upregulated Cancer) highly expressed tumor samples required cell proliferation, migration invasion...
Abstract Met tyrosine kinase inhibitors (Met-TKIs) subjected to ongoing clinical trials are a promising option for Met-amplified gastric cancer (GC), but how optimize their antitumor activity especially with combination schemes remains unclear. Since autophagy is known be initiated by Met-TKIs, we investigated its underlying mechanisms and therapeutic potentials of Met-TKIs combined against GC. As expected, four induced in GC cells marked p62 degradation, LC3-II accumulation increased...
We investigated antitumor activity and underlying mechanisms of DNA topoisomerase I (TopI) inhibitor gimatecan irinotecan in gastric cancer (GC) vitro cell lines vivo patient-derived xenograft (PDX) models. GC SNU-1, HGC27, MGC803 NCI-N87 were used to evaluate viability apoptosis after or treatment, using a proliferation assay flow cytometry, respectively. TopI expression critical molecules PI3K/AKT, MAPK signaling pathways analyzed with western blot. For studies, five PDXs models treated...
Abstract Background Renal colic is a surgical emergency in pregnancy that caused by range of non-obstetric factors and known to occur more frequently during the second third trimesters. Several studies have reported up 70–80% stones pass spontaneously pregnancy. There are some patients will not their ultimately require intervention. Through retrospective analysis clinical data 212 pregnant women with renal colic, predictive need intervention were determined. Methods We conducted review...
Abstract Lung cancer (LC) is the leading cause of cancer‐related mortality worldwide. Radiotherapy main component LC treatment; however, its efficacy often limited by radioresistance development, resulting in unsatisfactory clinical outcomes. Here, we found that radiosensitivity up‐regulated decreased expression long‐chain acyl‐CoA synthase 6 (ACSL6) after irradiation. Deletion ACSL6 results significant elevation Friend leukemia integration 1 transcription factor (FLI1) and a marked decline...
Purpose: Cancer stem cells (CSCs) are a subpopulation of cancer with self-renewal property and responsible for tumor malignancy, progression drug resistance. Researches on CSC-specific markers in gastric remain limited. Our current study explored the expression voltage-dependent calcium channel α2δ1 subunit potential using as CSC marker cancer. We also compared specificity CD44 identifying (GCSCs). Materials methods: Expression was analyzed cell lines, patient-derived xenograft (PDX) models...
As women with low ovarian reserve embark on the challenging journey of in-vitro fertilisation (IVF) treatment, choice between natural and mildly stimulated cycles becomes a pivotal consideration. It is unclear which these two regimens superior for reserve. Our study aims to assess impact embryo quality pregnancy outcomes in undergoing IVF treatment compared cycles.
ALYREF can recognize 5-methylcytosine (m5C) decoration throughout RNAs to regulate RNA metabolism. However, its implications in cancer and precise regulatory mechanisms remain largely elusive. Here, we demonstrated that supported colorectal (CRC) growth migration. Integrated analysis of ALYREF-RIP-Bis-seq transcriptome profiles identified ribosomal protein S6 kinase B2 (RPS6KB2) regulatory-associated mTOR (RPTOR) as ALYREF's possible downstream effectors. Mechanistically, formed a complex...
<b><i>Background:</i></b> Allergic rhinitis is an allergic inflammation of the nasal airways, and chronic rhinosinusitis paranasal sinuses. It can be induced by infection, allergy, or autoimmune problems. Diagnosis these two diseases made primarily based on clinical symptoms, allergen test, imaging. The test invasive expensive. imaging harmful to children. Measurement nitric oxide (NNO) was noninvasive, without radiation, inexpensive. This study evaluate significance...
Characterized by elevated AFP levels in serum, AFP-producing gastric cancer (APGC) is a very special type of (GC) that difficult to treat and has poor prognosis. However, little known about the role GC, which was investigated this study with vitro vivo experiments.APGC cells were established lentivirus infection validated PCR assay ELISA HCG27 AGS cells. Cell growth, migration, invasion determined CCK8, transwell assays, animal experiments. RNA sequencing, Western blot,...
Introduction: To investigate risk factors associated with urinary tract infection (UTI), following ureteral stenting, for patients renal colic during pregnancy. Patients and Methods: pregnancy who underwent stenting in The First Affiliated Hospital of Guangzhou Medical University between 2009 2019 were examined retrospectively. Ureteral had UTIs after hospital discharge before delivery classified as the infected group. Multivariate logistic regression analysis was used to assess UTI...
8552 Background: Extranodal NK/T-cell lymphoma, nasal type (ENKTL), is a rare and high aggressive disease with poor prognosis. The Ann Arbor staging system had been unable to define ENKTL in specific way. This study conduct new specified for ENKTL, which can identify prognostic patients who need more therapy. Methods: Based on the primary studied of one single center consecutive diagnosed as treated CHOP-like regimens ASCO meeting 2008, was established stage I: lesions confined within cavity...
// Xueying Li 1, * , Xiaojie Fang Su 2 Weijing Zhang 3 Nong Yang 4 Yimin Cui 5 He Huang 1 Ruiqing Cai Xiaoting Lin Xiaohong Fu Huangming Hong Tongyu Department of Medical Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory Oncology in Southern China, Collaborative Innovation Center Medicine, Guangzhou, China Clinical Trials Research Lymphoma, The 307th Hospital Chinese People's Liberation Army, Beijing, Hunan Hospital, Changsha, Pharmacy, Peking First These authors...