A5008638025- Advanced Combustion Engine Technologies
- Vehicle emissions and performance
- Lung Cancer Treatments and Mutations
- Metabolomics and Mass Spectrometry Studies
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Biodiesel Production and Applications
- Catalytic Processes in Materials Science
- Extracellular vesicles in disease
- Single-cell and spatial transcriptomics
- Combustion and flame dynamics
- HER2/EGFR in Cancer Research
- Supercapacitor Materials and Fabrication
- Cancer Immunotherapy and Biomarkers
- MicroRNA in disease regulation
- Advancements in Battery Materials
- Epigenetics and DNA Methylation
- Cancer-related Molecular Pathways
- Cancer-related molecular mechanisms research
- Cancer Genomics and Diagnostics
- PI3K/AKT/mTOR signaling in cancer
- Advanced battery technologies research
- Cancer Mechanisms and Therapy
- Colorectal and Anal Carcinomas
- Fatty Acid Research and Health
Guizhou University
2020-2024
Peking University
2015-2024
Beijing Information Science & Technology University
2024
Peking University Third Hospital
2019-2024
Ministry of Agriculture and Rural Affairs
2023-2024
Henan Agricultural University
2023-2024
University of Pittsburgh Medical Center
2024
UPMC Hillman Cancer Center
2022-2024
Hebei Agricultural University
2023-2024
Zhengzhou University
2022-2024
Abstract Paclitaxel (PTX) is widely used in the front-line chemotherapy for gastric cancer (GC), but resistance limits its use. Due to lack of proper models, mechanisms underlying PTX GC were not well studied. Using established PTX-resistant cell sublines HGC-27R, we first time integrated biological traits and molecular GC. Data revealed that cells characterized by microtubular disorders, an EMT phenotype, reduced responses antimitotic drugs, apoptosis (marked upregulated β-tubulin III,...
Abstract Power generation systems will reduce carbon emissions primarily through the application of low or even zero fuels under global decarbonization trend. Ammonia is an ideal alternative fuel because it cheap, readily available, and easy to store transport. However, its mediocre combustion performance has raised concerns about use in engines. The objective this paper was evaluate amount hydrogen that would need be added ammonia from a laminar flame speed perspective if converting...
Market globalization necessitates the development of heavy duty diesel engines that can operate at altitudes up to 5000 m without significant performance deterioration. But current scenario is existing studies on high altitude effects are still not sufficient or detailed enough take effective measures. This study applied a single cylinder direct injection engine with simulated boosting pressure investigate degradation altitude, aim adding more knowledge literature. Such research was...
Since its selection as the method of year in 2013, single-cell technologies have become mature enough to provide answers complex research questions. With growth profiling technologies, there has also been a significant increase data collected from profilings, resulting computational challenges process these massive and complicated datasets. To address challenges, deep learning (DL) is positioned competitive alternative for analyses besides traditional machine approaches. Here, we survey...
SARS-CoV-2 vaccines have contributed to the control of COVID-19 in some parts world. However, constant emergence variants concern (VOCs) challenges effectiveness over time. In particular, Omicron contains a high number mutations spike (S) protein gene, on which most were developed. this study, we quantitated neutralizing antibodies vaccine recipients at various times postvaccination using S protein-based pseudoviruses derived from wild type (WT) and five VOCs including Alpha (B.1.1.7), Beta...
Supercapacitors are widely used in many fields owing to their advantages, such as high power, good cycle performance, and fast charging speed. Among the metal-oxide cathode materials reported for supercapacitors, NiMoO
Cell cycle dysregulation is common in human malignancies, and CDK4/6 inhibitors targeting cell have potential antitumor activity. SHR6390 a novel small molecule inhibitor specifically the pathway. However, role of esophageal squamous carcinoma (ESCC) remains unknown, which will be investigated our study.Eca 109, Eca 9706, KYSE-510 ESCC lines were chosen for further analysis. The effect on viability, apoptosis, status kinases Cyclin D1-CDK4/6-Rb pathway determined by MTS assay, flow...
Abstract Diesel engines are the predominant power source for trucking industry. Heavy-duty trucks carry more than 70% of all goods transported across United States. Atmospheric conditions vary with altitude but critical to diesel engine performance, efficiency, and emissions. Existing studies have reported reduced thermal efficiency increased emissions when truck were operated at high altitudes. Since heat loss is a key parameter related goal this paper was investigate impacts on in-cylinder...
Patient-derived xenograft (PDX) models with definite molecular signature are attractive preclinical for development of novel targeted drugs. Here, we profiled and explored potential therapeutic targets based on characterized PDX advanced gastric cancer (AGC). The genomic variation profile 50 from AGC patients were analyzed by next-generation sequencing, in situ hybridization, immunohistochemistry. antitumor activities several drugs investigated the models. Furthermore, response biomarkers...
Abstract Concern over the change of atmospheric conditions at high altitudes prompted interests in deteriorated efficiency and emissions from heavy-duty diesel engines. This study utilized a single-cylinder, four-stroke, direct injected engine to experimentally investigate altitude effects on combustion characteristics. High operations were simulated via reducing intake pressure but maintaining constant speed load. The results suggested reduced in-cylinder trace an increased bulk cylinder...
Significance Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI) have demonstrated clinical benefits for patients suffering from non–small cell lung cancer of adenocarcinoma with activating mutation EGFR. Same mutations observed in squamous carcinoma do not offer similar benefits. The underlining resistance mechanism revealed this study turns out to be the concurrent activation bone morphogenetic proteins (BMPs) signaling pathway carcinoma. combination EGFR-TKI BMP...
Abstract Plateau diesel engines suffer from increased fuel consumption and deteriorating emissions. These problems were mainly caused by the combustion worsening inside chamber. However, limited research has been done specifically on effect of altitude process engine cycles, which would obviate feasibility optimizing high engines. As a result, goal this study was to apply zero-dimensional modeling approach deeply analyze influence combustion. A triple Wiebe function model calibrated based...
Despite intensive studies during the last 3 years, pathology and underlying molecular mechanism of coronavirus disease 2019 (COVID-19) remain poorly defined. In this study, we investigated spatial single-cell cellular features postmortem COVID-19 lung tissues using in situ sequencing (ISS). We detected 10 414 863 transcripts 221 genes whole-slide segmented them into 1 719 459 cells that were mapped to 18 major parenchymal immune cell types, all which infected by SARS-CoV-2. Compared with...