A5041213358- Cancer Immunotherapy and Biomarkers
- Advanced Battery Materials and Technologies
- Advancements in Battery Materials
- Gastric Cancer Management and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Advanced Battery Technologies Research
- Immune cells in cancer
- HER2/EGFR in Cancer Research
- Membrane Separation Technologies
- Monoclonal and Polyclonal Antibodies Research
- Genetic factors in colorectal cancer
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Peptidase Inhibition and Analysis
- Cancer-related molecular mechanisms research
- Artificial Intelligence in Healthcare and Education
- Acute Myeloid Leukemia Research
- Heme Oxygenase-1 and Carbon Monoxide
- Colorectal Cancer Treatments and Studies
- Gastrointestinal Tumor Research and Treatment
- Pancreatic and Hepatic Oncology Research
- Immune Cell Function and Interaction
- Nanopore and Nanochannel Transport Studies
- Carbon and Quantum Dots Applications
- Cancer Cells and Metastasis
ZheJiang Institute For Food and Drug Control
2022-2025
Peking University
2016-2025
Peking University Cancer Hospital
2016-2025
Shenzhen Polytechnic
2025
Chengdu University of Technology
2021-2024
Nanjing University of Science and Technology
2024
Southwest University
2023-2024
Shaanxi University of Science and Technology
2023
Shandong First Medical University
2023
Shandong Tumor Hospital
2023
Abstract Despite success in hematologic malignancies, the treatment landscape of chimeric antigen receptor (CAR) T cell therapy for solid tumors remains limited. Claudin18.2 (CLDN18.2)-redirected CAR cells showed promising efficacy against gastric cancer (GC) a preclinical study. Here we report interim analysis results an ongoing, open-label, single-arm, phase 1 clinical trial CLDN18.2-targeted (CT041) patients with previously treated, CLDN18.2-positive digestive system cancers ( NCT03874897...
The diffuse-type gastric cancer (DGC) is a subtype of with the worst prognosis and few treatment options. Here we present dataset from 84 DGC patients, composed proteome 11,340 gene products mutation information 274 driver genes covering paired tumor nearby tissue. can be classified into three subtypes (PX1-3) based on altered alone. PX1 PX2 exhibit dysregulation in cell cycle features an additional EMT process; PX3 enriched immune response proteins, has survival, insensitive to...
Carboxyl groups on the separator improve lithium ion transport rate by 6 times in battery.
Abstract A single biomarker is not adequate to identify patients with gastric cancer (GC) who have the potential benefit from anti-PD-1/PD-L1 therapy, presumably owing complexity of tumour microenvironment. The predictive value tumour-infiltrating immune cells (TIICs) has been definitively established regard their density and spatial organisation. Here, multiplex immunohistochemistry used quantify in situ biomarkers at sub-cellular resolution 80 GC. To predict response immunotherapy, we...
Abstract Purpose RC48 contains the novel humanized anti-HER2 antibody hertuzumab conjugated to MMAE via a cleavable linker. A phase I study was initiated evaluate toxicity, MTD, PK, and antitumor activity of in patients with HER2-overexpressing locally advanced or metastatic solid carcinomas, particularly gastric cancer. Patients methods This 2-part study. Successive cohorts received escalating doses (0.1 mg/kg, 0.5 1.0 2.0 2.5 3.0 mg/kg). Dose expansion proceeded at dose mg/kg Q2W. The...
Although the antibody-drug conjugates (ADCs) have significantly improved survival outcomes of patients with human epidermal receptor 2 (HER2)-expressing gastric or gastroesophageal junction (G/GEJ) cancer, efficacy ADC used as a single agent is limited. Therefore, it necessary to investigate effective and safe combination regimens. Preclinical data indicated synergetic antitumour effect RC48 programmed cell death protein 1 (PD-1) inhibitors. We aimed evaluate safety plus toripalimab in...
With the rapid development of artificial intelligence, large language models (LLMs) have shown promising capabilities in mimicking human-level comprehension and reasoning. This has sparked significant interest applying LLMs to enhance various aspects healthcare, ranging from medical education clinical decision support. However, medicine involves multifaceted data modalities nuanced reasoning skills, presenting challenges for integrating LLMs. review introduces fundamental applications...
Hepatoid adenocarcinoma of the stomach (HAS) is characterized by histological resemblance to hepatocellular carcinoma and a poor prognosis. The aim this study elucidate clinicopathological molecular characteristics HAS.Forty-two patients with HAS who received gastrectomy were enrolled in study. Based on panel 483 cancer-related genes, targeted sequencing 24 22 clinical parameter-matched common gastric cancer (CGC) samples was performed. Prognostic factors for overall survival (OS)...
Abstract Background The FAST study identified claudin-18 (CLDN18.2) as a promising novel therapeutic target for gastric cancer (GC). However, the tumor immune microenvironment and clinicopathological features of CLDN18.2-positive GC are unclear, making it difficult to develop optimize CLDN18.2-targeted treatments. Methods This included 80 patients, 60 whom received anti-PD-1/PD-L1 treatment. CD4/CD8/CD20/CD66b/CD68/CD163/PD-1/PD-L1/TIM-3/LAG-3/FoxP3/CTLA-4/HLA-DR/STING, CLDN18.2 were labeled...
Abstract Background Tertiary lymphoid structures (TLS) correlate with tumour prognosis and immunotherapy responses in gastric cancer (GC) studies. However, understanding the complex diverse immune microenvironment within TLS requires comprehensive analysis. Methods We examined prognostic impact of core (TC) 59 GC patients undergoing immunotherapy. Multispectral fluorescence imaging was employed to evaluate variations cell infiltration across different sites among 110 patients, by quantifying...
The left and right sides of the nervous system communicate via commissural axons that cross midline during development using evolutionarily conserved molecules. These guidance cues have been particularly well studied in mammalian spinal cord, but it remains unclear whether these mechanisms for are similar developing forebrain, particular corpus callosum, largest most important commissure cortical function. Here, we show Netrin1 initially attracts callosal pioneering derived from cingulate...
Background and Aims: We evaluated the efficacy safety of antiangiogenic tyrosine kinase inhibitor anlotinib plus TQB2450, a programmed death‐ligand 1 in pretreated advanced biliary tract cancers (BTCs). Approach Results: In this pooled analysis two single‐center, phase Ib clinical trials (TQB2450‐Ib‐05 TQB2450‐Ib‐08 trials), 66 patients with BTCs who had progressed or declined were ineligible for first‐line chemotherapy included. With treatment achieved complete response, 12 partial response...
Cell cycle dysregulation is common in human malignancies, and CDK4/6 inhibitors targeting cell have potential antitumor activity. SHR6390 a novel small molecule inhibitor specifically the pathway. However, role of esophageal squamous carcinoma (ESCC) remains unknown, which will be investigated our study.Eca 109, Eca 9706, KYSE-510 ESCC lines were chosen for further analysis. The effect on viability, apoptosis, status kinases Cyclin D1-CDK4/6-Rb pathway determined by MTS assay, flow...