A5069341396- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Hepatitis B Virus Studies
- Pancreatic and Hepatic Oncology Research
- Drug-Induced Hepatotoxicity and Protection
- Cancer, Hypoxia, and Metabolism
- Autophagy in Disease and Therapy
- Mitochondrial Function and Pathology
- Liver physiology and pathology
- Cancer Immunotherapy and Biomarkers
- Pancreatitis Pathology and Treatment
- Organ Transplantation Techniques and Outcomes
- Genomics, phytochemicals, and oxidative stress
- Hepatitis C virus research
- Hormonal and reproductive studies
- Immunotherapy and Immune Responses
- Ocular Surface and Contact Lens
- Hepatocellular Carcinoma Treatment and Prognosis
- Epigenetics and DNA Methylation
- Growth Hormone and Insulin-like Growth Factors
- Metabolism and Genetic Disorders
- Corneal Surgery and Treatments
- Ocular Infections and Treatments
- Aquaculture Nutrition and Growth
- Flavonoids in Medical Research
Peking University
2019-2025
Peking University Cancer Hospital
2019-2025
Beijing Fengtai Hospital
2025
Beijing University of Chinese Medicine
2025
Sun Yat-sen University
2022
Beijing YouAn Hospital
2016-2021
Capital Medical University
2016-2020
Zhengzhou University
2019-2020
Zhejiang Ocean University
2019-2020
Beijing Chao-Yang Hospital
2017-2019
Although massive hepatocyte cell death and oxidative stress constitute major events of acute-on-chronic liver failure (ACLF), the relationship ferroptosis with ACLF has yet to be explored. Nuclear factor erythroid 2-related 2 (Nrf2) is a key regulator ferroptosis. However, if Nrf2 modulates through remains unknown. Here, tissues patients were collected murine models using carbon tetrachloride, D-galactosamine, lipopolysaccharide as well an H2O2-induced injury model established. Upon ACLF,...
Aim . Pancreatic cancer is one of the most quickly fatal cancers around world. Burgeoning researches have begun to prove that mitochondria play a crucial role in treatment. Mitofusin2 (Mfn2) plays an indispensable mitochondrial fusion and adjusting function. However, underlying mechanisms Mfn2 on cell autophagy pancreatic still unclear. Our aim was explore effect multiple biological functions involving cancer. Methods line, Aspc‐1, treated with Ad‐Mfn2 overexpression. Western blotting,...
Aim . Pancreatic stellate cells (PSCs) play a pivotal role in pancreatic fibrosis. Any remedies that inhibit the activation of PSCs can be potential candidates for therapeutic strategies fibrosis-related ductal adenocarcinoma (PDAC) and chronic pancreatitis (CP). Our study is aimed at exploring protective effect coenzyme Q10 (CoQ10) against Methods fibrosis was induced by 20% L-arginine (250 mg/100 g) 1 h intervals twice per week 8 weeks C57BL/6 mice. CoQ10 administered 4 weeks. Isolated...
Hyperglycemia has been widely considered as a key risk factor for diabetic encephalopathy which can cause neuronal apoptosis and cognitive deficits. The flavonoid compound, fisetin, possesses potential neuroprotective effects also enhances learning memory. However, the role of fisetin in hyperglycemia-induced cytotoxicity not fully elucidated. In present study, HT22 murine hippocampal cell line was used to establish injured model. Cell proliferation assay, hoechst 33258 staining, qRT-PCR,...
Pancreatic stellate cells (PSCs) have a vital role in pancreatic fibrosis accompanied by ductal adenocarcinoma (PDAC) and chronic pancreatitis (CP). Any agents which can affect the activation of PSCs could become potential candidates for treatment strategies PDAC CP. Our aim was to explore effect Coenzyme Q10 (CoQ10) process activation.Isolated from C57BL/6 mice were treated with various dosages CoQ10 (1, 10, 100μM) different time (24h, 48h, 72 h). Effect on autophagy, apoptosis, senescence...
Hemp seed has been used as a traditional oriental medicine and health food in China for centuries. Polysaccharides from hemp (HSP) exhibit important properties of intestinal protection, but there are limited data on the specific underlying mechanism. The primary objective this study was to investigate protective effect HSP oxidative damage induced by cyclophosphamide (Cy) mice. results showed that pretreatment with significantly increased average daily gain, thymus index, spleen superoxide...
Abstract Background and Aim Glypican‐3 (GPC3) expression is correlated with poor prognosis progression in hepatocellular carcinoma (HCC). HCC can be associated the differentiation status of tumor cell before malignant transformation. Our aim was to investigate dynamic GPC3 during cells explore role theoretical significance essence HCC. Methods The expressions tissue alpha fetoprotein (AFP) were detected by immunohistochemical staining. size, lymph node involvement, metastasis determined...
Aim Acute-on-chronic liver failure (ACLF) is closely related to mitochondrial dysfunction. Previous studies showed the vital role of mitofusin2 (Mfn2) in regulation function. However, effect Mfn2 on ACLF remains unknown. As one mitochondrial-related pathways, BNIP3-mediated pathway controls balance between apoptosis and autophagy. relationship still obscure. The aim our study clarify potential molecular mechanisms ACLF. Methods We collected tissue from patients constructed an animal model a...
This study aimed to determine if the immunoscore (IS) staging system would be a potential prognostic factor in hepatitis B virus-related hepatocellular carcinoma (HBV-HCC) China. IS was performed consecutive cohort of HBV-HCC patients (n= 92). CD3+, CD8+, and CD45RO+ T cells were quantified by immunohistochemical analyses. The stratified into 5 groups: I0, I1, I2, I3, I4 for every 2 cell phenotypes (IS1 (CD8/CD45RO, IS2 (CD3/CD8), IS3 (CD3/CD45RO), respectively. ImagePro Plus software used...
Abstract Acute‐on‐chronic liver failure (ACLF) is a life‐threatening syndrome with poor prognosis. Several studies have begun to prove that mitochondria play crucial role in failure. Mitofusin2 (Mfn2) plays key maintaining the integrity of mitochondrial morphology and function. However, underlying mechanisms Mfn2 on cell autophagy ACLF remain unclear. Our aim was explore effect several biological functions involving ACLF. In this study, we constructed an animal model hepatocyte model, using...
Pancreatic cancer is a fatal malignancy with poor prognosis. The interactions between tumor cells and stromal contribute to progression. stellate (PSCs) play key role in tumor-stroma crosstalk of pancreatic cancer. in-depth exploration for helpful develop novel therapeutic strategies. Our aim was identify the potential core genes pathways crosstalk.3 microarray datasets were from Gene Expression Omnibus (GEO). Differentially expressed (DEGs) screened through bioinformatics analysis. Ontology...
Abstract Energy metabolism in patients with Hepatocellular carcinoma (HCC) accompanying by hepatitis B cirrhosis is unknown. To compare the differences liver functions and energy between B-related HCC. This was a retrospective study of (LC group, n = 75) HCC (HCC 80) treated Beijing You’an Hospital January 2013 June 2017. The resting expenditure (REE), respiratory quotient (RQ), carbohydrate oxidation rate (CHO%), fat (FAT%), protein (PRO%) were measured using metabolic cart. Liver function,...
Abstract Background Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is a severe condition with high mortality due to lack of efficient therapy. Until now, the use methylprednisolone (MP) in HBV-ACLF still controversial. We aimed evaluate efficacy and safety MP HBV-ACLF. Methods Totally 171 patients from three medical centers were randomly allocated into group (83 treated intravenously guttae for 7 days plus standard treatment: 1.5 mg/kg/day [day 1–3], 1 4–5], 0.5 6–7])...
It is challenging to predict the outcome of patients with hepatitis B virus related acute-on-chronic liver failure (HBV-ACLF) through existing prognostic models. Our aim was establish a novel dynamic model improve predictive efficiency 30-day mortality in HBV-ACLF patients.305 who were diagnosed as (derivation cohort, n=211; validation n=94) included this study. The (HBV-ACLFD) constructed based on daily levels variables 7 days after diagnosis combined baseline risk factors by multivariate...
Acute-on-chronic liver failure (ACLF) is a lethal syndrome with remarkable short-term death rate. Even worse, effective internal medicine therapies are currently lacking. Increasing evidence indicates apoptosis plays critical role in the progression of failure. PINK1 has an essential function maintaining cell survival. However, and underlying mechanism ACLF incompletely understood. Herein, our team discovered that remarkably improved ACLF, featured by reduction aspartate aminotransferase...