A5082841104- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Liver Disease Diagnosis and Treatment
- Gastroesophageal reflux and treatments
- Helicobacter pylori-related gastroenterology studies
- Esophageal and GI Pathology
- Liver Disease and Transplantation
- Genetic factors in colorectal cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Colorectal Cancer Screening and Detection
- Eosinophilic Esophagitis
- Gallbladder and Bile Duct Disorders
- Gastrointestinal motility and disorders
- Epigenetics and DNA Methylation
- Pediatric Hepatobiliary Diseases and Treatments
- Esophageal Cancer Research and Treatment
- Medical Research and Treatments
- Pancreatic function and diabetes
- Berberine and alkaloids research
- Inflammatory Bowel Disease
- Hepatocellular Carcinoma Treatment and Prognosis
- Biliary and Gastrointestinal Fistulas
- Colorectal Cancer Surgical Treatments
- Organ Transplantation Techniques and Outcomes
Chengdu Academy of Agriculture and Forestry Sciences
2025
Beijing Chao-Yang Hospital
2015-2024
Capital Medical University
2015-2024
Beijing Chaoyang Emergency Medical Center
2012-2022
Changchun Institute of Technology
2021
Yang Hospital
2010-2019
Jilin Agricultural University
2018
Specifica (United States)
2016
Xiaomi (China)
2016
Dalian Polytechnic University
2016
Adenoma detection rate (ADR) is a key colonoscopy quality indicator in Western clinical literature. Our low ADR prompted us to assess novel methods improve performance. retrospective reports suggested that water exchange (WE) could increase ADR. However, most of these studies used pain score or intubation as the primary outcome. Here we test hypothesis WE significantly increases among Chinese colonoscopists and design prospective randomized controlled trial using our outcome.This...
Background Inflammatory bowel disease (IBD) is characterized by immune-mediated, chronic inflammation of the intestinal tract. The occurrence IBD driven complex interactions multiple factors. objective this study was to evaluate therapeutic effects IAA in colitis.
Abstract Background The study evaluated efficacy and safety of the 2 mg dose prucalopride compared to placebo in patients with chronic constipation (CC) from Asia‐Pacific region. Methods Randomized, placebo‐controlled, parallel‐group, phase III 2‐week run‐in, 12‐week treatment phase, 1‐week follow‐up. Adult CC (≤2 spontaneous bowel movements per week) received or placebo, once‐daily, for 12 weeks. Primary measure was percentage average ≥3 complete (SCBMs) week (Responders) during treatment....
Cetuximab plus chemotherapy for advanced gastric cancer (GC) shows an active result in phase 2 trials. Unfortunately, Combination of cetuximab does not provide enough benefit to alone 3 Studies have demonstrated that berberine can suppress the activation EGFR tumors. In this study, we evaluated whether could enhance effects EGFR-TKIs GC cell lines and xenograft models. Our data suggest effectively activity erlotinib vitro vivo. Berberine was found inhibit growth induce apoptosis. These were...
Abstract Background and Aim: To profile changes of coagulation, anticoagulation fibrolytic factors associated with liver function failure portal vein thrombosis (PVT) formation in chronic cirrhosis patients. Methods: A total 116 cirrhotic patients admitted to our hospital from June 2006 October 2008 were included study. All classified into two groups: PVT group (31 patients), composed a control (85 including without PVT. Platelet, prothrombin time (PT), activated partial (APTT) fibrinogen...
Recently, Gastroesophageal Reflux Disease Questionnaire (GerdQ) has been developed for diagnosis of GERD. However, no study investigated its value in real-world practice. This aimed to investigate whether GerdQ can be used GERD China.A national multicenter survey was undertaken; all patients who underwent first diagnostic upper endoscopy gastrointestinal (GI) symptoms were included. Data including the gender, age, symptoms, and endoscopic findings prospectively recorded. The score measured...
In recent years, with the developing of living standard, hyperlipidemia becomes second major reason acute pancreatitis. It is important to predict severity and prognosis at early stage hyperlipidemic pancreatitis (HLAP). We compared BISAP, Ranson, MCTSI, APACHE II scoring system in predicting MSAP SAP, local complications, mortality HLAP. A total 326 diagnosed patients from August 2006 July 2015 were studied retrospectively. Our result showed that all four systems can be used severity,...
Aim . Pancreatic cancer is one of the most quickly fatal cancers around world. Burgeoning researches have begun to prove that mitochondria play a crucial role in treatment. Mitofusin2 (Mfn2) plays an indispensable mitochondrial fusion and adjusting function. However, underlying mechanisms Mfn2 on cell autophagy pancreatic still unclear. Our aim was explore effect multiple biological functions involving cancer. Methods line, Aspc‐1, treated with Ad‐Mfn2 overexpression. Western blotting,...
Aim . Pancreatic stellate cells (PSCs) play a pivotal role in pancreatic fibrosis. Any remedies that inhibit the activation of PSCs can be potential candidates for therapeutic strategies fibrosis-related ductal adenocarcinoma (PDAC) and chronic pancreatitis (CP). Our study is aimed at exploring protective effect coenzyme Q10 (CoQ10) against Methods fibrosis was induced by 20% L-arginine (250 mg/100 g) 1 h intervals twice per week 8 weeks C57BL/6 mice. CoQ10 administered 4 weeks. Isolated...
Monolepta hieroglyphica (Motschulsky) (Coleoptera: Chrysomelidae) is widely distributed in China and polyphorous, being a major pest to cash crops, such as corn, cotton, millet. Given the increasing severity of greenhouse effect recent years, we aimed investigate adaptability M. adults varying temperatures. In this study, assessed survival, longevity, fecundity, feeding capacity, antioxidant capacity leaf beetle under laboratory conditions at 25-34 °C. Elevated temperatures (i.e., 31 34 °C)...
Pancreatic stellate cells (PSCs) have a vital role in pancreatic fibrosis accompanied by ductal adenocarcinoma (PDAC) and chronic pancreatitis (CP). Any agents which can affect the activation of PSCs could become potential candidates for treatment strategies PDAC CP. Our aim was to explore effect Coenzyme Q10 (CoQ10) process activation.Isolated from C57BL/6 mice were treated with various dosages CoQ10 (1, 10, 100μM) different time (24h, 48h, 72 h). Effect on autophagy, apoptosis, senescence...
// Di Lu 1 , Junxiong Wang Xiaoyan Shi 2 Bing Yue and Jianyu Hao Department of Gastroenterology, Beijing Chao-Yang Hospital, Capital Medical University, 100020, China Pathology, Friendship 100050, Correspondence to: Hao, email: haojianyu@medmail.com.cn Keywords: AHNAK2, pancreatic ductal adenocarcinoma, overall survival, prognostic factor, nomogram Received: October 09, 2016     Accepted: February 21, 2017     Published: March 07, 2017 ABSTRACT...
Objective Late complications after endoscopic biliary sphincterotomy (EST) include stone recurrence, but no definite risk factors for recurrence have been established. This study was performed to identify the predictors of and evaluate clinical outcomes EST common bile duct stones. Methods In total, 345 eligible patients who successfully underwent were evaluated followed up. Statistical analysis on with or had undergone at least 6 months reliable follow-up detect recurrence. Results A total...
Background & AimsGenome-wide association studies (GWAS) and transcriptome analyses have been performed to better understand the pathogenesis of ulcerative colitis (UC). However, current mainly focus on European ancestry, highlighting a great need identify key genes, pathways cell types in colonic mucosal cells adult UC patients from other ancestries. Here we aimed genes UC.MethodsWe Single-cell RNA sequencing (scRNA-seq) analysis 12 colon biopsies healthy controls Chinese Han...
To investigate the value of D-dimer and protein S plasma concentrations for diagnosis portal vein thrombosis (PVT) in patients with liver cirrhosis.D-dimer were quantified, PVT was diagnosed by dynamic enhanced computed tomography function classified using Child-Pugh system. Receiver operating curve analysis performed.D-dimer increased, decreased, decreasing total study population (n = 188). significantly higher lower 51) than those without 137). had high specificity negative predictive...
Objective To assess changes in anticoagulation and fibrinolytic systems between biliary hyperlipidaemic acute pancreatitis (AP). Methods Patients with or AP were enrolled. Demographic clinical data collected, antithrombin III (ATIII), protein C, S, D-dimer levels investigated. Results A total of 45 patients 50 included (68 mild 27 moderately-severe AP). ATIII C the group significantly higher, but prothrombin time lower, versus group. found to be risk factors for AP. could predict severity,...
Background: Chronic pancreatitis (CP) is a long-term inflammatory disease of the pancreas that can be caused by various pathogenic factors. Oxidative stress (OS), which associated with several pancreatic diseases, induce stellate cell (PSC) activation, leading to fibrosis. Given inefficacy existing treatments for CP, in this study, our objective was evaluate therapeutic effect antioxidant, mitoquinone (MitoQ). Methods: First, vivo, we established CP mouse model via repeated injection...