A5101940738- Gastroesophageal reflux and treatments
- Esophageal and GI Pathology
- Gastric Cancer Management and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Esophageal Cancer Research and Treatment
- Dysphagia Assessment and Management
- Gastrointestinal disorders and treatments
- Colorectal Cancer Screening and Detection
- Liver Disease and Transplantation
- Pancreatic and Hepatic Oncology Research
- Eosinophilic Esophagitis
- Radiopharmaceutical Chemistry and Applications
- RNA modifications and cancer
- Gastrointestinal motility and disorders
- Minimally Invasive Surgical Techniques
- Nanoplatforms for cancer theranostics
- Gastrointestinal Tumor Research and Treatment
- Cancer-related molecular mechanisms research
- Renal cell carcinoma treatment
- Monoclonal and Polyclonal Antibodies Research
- Infant Health and Development
- Lung Cancer Research Studies
- Peptidase Inhibition and Analysis
- Pathogenesis and Treatment of Hiccups
- Metabolism, Diabetes, and Cancer
Qingdao University
2015-2024
Jilin University
2013-2024
First Hospital of Jilin University
2010-2024
Affiliated Hospital of Qingdao University
2015-2024
Changhai Hospital
2023
Second Military Medical University
2023
Southwest Medical University
2023
Tianjin Medical University Cancer Institute and Hospital
2023
Zunyi Medical University
2022
Shanghai East Hospital
2022
Adropin has been identified as potent regulatory hormone implicated in insulin sensitivity and the maintenance of energy homeostasis. The aim current study was to investigate serum adropin concentrations type 2 diabetes mellitus (T2DM) patients fasting status, especially those overweight/obese evaluate relationships between levels metabolic parameters. A total 116 T2DM 60 controls with normal glucose tolerance (NGT) were recruited study. concentration determined using commercial ELISA kits....
One of the primary targets clinical treatment ulcerative colitis (UC) is to repair damaged colonic mucosa. Mesenchymal stem cells (MSCs) have therapeutic potential in regenerative medicine due their differentiation capacity and secretion numerous bioactive molecules. The present study describes a trial (trial registration no. NCT01221428) investigating safety effect MSCs derived from human umbilical cord on moderate severe UC. Thirty-four patients with UC were included group I treated MSC...
Photodynamic therapy (PDT) is a promising treatment modality for clinical cancer therapy. However, the therapeutic effect of PDT strongly dependent on property photosensitizer. Here, we developed photo-cross-linkable semiconductor polymer dots doped with photosensitizer Chlorin e6 (Ce6) to construct nanoparticle platform photodynamic Photoreactive oxetane groups were attached side chains polymer. After photo-cross-linking reaction, Ce6-doped Pdots formed an interpenetrated structure prevent...
Abstract Objective To investigate the safety and feasibility of using a novel purpose-built single-port robotic system (the SHURUI Robotic Surgical System) with deformable surgical instruments to perform retroperitoneal partial nephrectomy. Materials methods A prospective study was conducted recruit patients single renal tumor no more than 4 cm. Robot-assisted nephrectomy performed by instruments. Patients’ demographics, characteristics, perioperative parameters were recorded analyzed....
Recently, Gastroesophageal Reflux Disease Questionnaire (GerdQ) has been developed for diagnosis of GERD. However, no study investigated its value in real-world practice. This aimed to investigate whether GerdQ can be used GERD China.A national multicenter survey was undertaken; all patients who underwent first diagnostic upper endoscopy gastrointestinal (GI) symptoms were included. Data including the gender, age, symptoms, and endoscopic findings prospectively recorded. The score measured...
Abstract Primary tumor resection (PTR) is recommended for patients with unresectable stage IV colorectal cancer (CRC) who present symptoms related to their primary tumor. However, the survival benefit of PTR asymptomatic controversial. We investigated change in rates and contribution CRC over past two decades United States. Clinicopathological factors long-term were compared 44 514 diagnosed from January 1, 1988, through December 31, 2010, had or not undergone PTR. Multivariable Cox...
With the digestive endoscopic tunnel technique (DETT), many diseases that previously would have been treated by surgery are now endoscopically curable establishing a submucosal between mucosa and muscularis propria (MP). Through tunnel, diagnosis or treatment is performed for lesions in mucosa, MP, even outside gastrointestinal (GI) tract. At present, application range covers following: (1) Treatment of originating from mucosal layer,
Study Design: Hospital-based retrospective studyObjectives: To evaluate the pathogenetic features of traumatic spinal cord injury (TSCI) during 1999–2016 according to changed etiology with time, explore different characteristics patients suffered a TSCI 1999–2007 and 2008–2016 in Tianjin, China.Setting: Tianjin Medical University General HospitalMethods: In this study, medical records were obtained from Hospital (TMUGH) 1st January 1999 31th December 2016. Variables recorded, including age,...
Gastric cancer, as a multifactorial disorders, shows cytological and architectural heterogeneity compared to other gastrointestinal cancers, making it therapeutically challenging. Cisplatin is generally used in clinic for gastric cancer treatment but with toxic side effects develops resistance. Anti-tumor properties of copper its coordinated compounds have been explored intensively recent years.In this study, we synthesized novel Schiff base compound (SBCCC) examined antitumor two cell lines...
Background Imbalanced nutritional supply and demand in the tumor microenvironment often leads to hypoxia. The subtle interaction between hypoxia immune cell behavior plays an important role occurrence development. However, functional relationship remains unclear. Therefore, we aimed investigate effect of on intestinal microenvironment. Method We extracted names hypoxia-related genes from Gene Set Enrichment Analysis (GSEA) database screened them for those associated with colorectal cancer...
HER2-positive breast cancer was aggressive, resulting in a poorer prognosis. This multicenter study analyzed the real-world data of women treated with pyrotinib-based therapy, aiming to describe their characteristics, treatment regimens, and investigate clinical outcomes.A total 141 patients were enrolled from February 2019 April 2020. Last follow-up time 2021. All therapy 21-day cycles. The primary endpoint progression-free survival (PFS).The median PFS (mPFS) for 12.0 months (95%CI...
3596 Background: Colorectal cancer (CRC) is the second most frequently diagnosed in China and early detection could prevent over 90% of CRC-related deaths. Blood-based tests that analyze molecular features CRC cell-free DNA (cfDNA), such as methylation fragmentation patterns, hold great promise for detection. However, impact characteristics related to tumor location or mismatch repair (MMR) status on test performance has not been thoroughly investigated. In this study, we developed a...
4070 Background: Esophageal cancer (EC) is a major malignancy of the upper gastrointestinal tract globally. Early detection and timely therapeutic intervention are pivotal in improving patient outcomes. However, current diagnostic methods often fail to detect EC at an early stage lack ability predict treatment response. There urgent need for non-invasive, sensitive, specific biomarkers enhance guide personalized strategies. This study aims develop tool neoadjuvant efficacy. Methods:...
Diffuse large B-cell lymphoma (DLBCL) is an aggressive hematopoietic malignancy, necessitating the exploration of innovative therapeutic approaches. Targeting epigenetic mechanisms has emerged as a promising avenue for cancer treatment. EP300 belongs to KAT3 family histone/non-histone lysine acetyltransferases, regulating gene expression by acetylating H3K27. However, role and its potential targeted therapy in DLBCL remains unknown. Public datasets were collected evaluate clinical...
The efficacy and safety of polaprezinc combined with triple therapy was compared alone in the eradication Helicobacter pylori. A randomized, parallel-group, open-label, controlled, prospective multicenter study conducted 11 cities China. Treatment-naive patients H. pylori-associated gastritis were randomly assigned to one three arms for a 14-day treatment: Arm (omeprazole 20 mg, amoxicillin 1 g, clarithromycin 500 each twice daily) plus 75 mg daily; B 150 daily, or C alone. rate pylori...
Maren pills have been used to treat constipation. Aquaporin 3 (AQP3) plays a vital role in regulating water transfer the colon. It has reported that downregulation of AQP3 can regulate liquid metabolism and intestinal permeability irritable bowel syndrome (IBS) rats' colon via NF-κB pathway. In this study, we investigated whether laxative effect is associated with regulation signaling pathway colon.The compound diphenoxylate suspension-induced STC rats received intragastrically for 1...
This prospective single-arm clinical trial aimed to evaluated the feasibility and safety of application SHURUI system, a novel purpose-built robotic in single-port radical prostatectomy. Sixteen patients diagnosed with prostate cancer were prospectively enrolled received prostatectomy from October 2021 August 2022. The demographic baseline data, surgical, oncological, functional outcomes as well follow-up data recorded. mean operative time was 226.3 (SD: 52.0) min, console 183.4 (SD 48.3) an...