A5002813931- Renal cell carcinoma treatment
- Bladder and Urothelial Cancer Treatments
- Ferroptosis and cancer prognosis
- Urinary and Genital Oncology Studies
- Minimally Invasive Surgical Techniques
- Renal and related cancers
- Renal and Vascular Pathologies
- Renal Transplantation Outcomes and Treatments
- Cancer Genomics and Diagnostics
- Cancer Mechanisms and Therapy
- Pediatric Urology and Nephrology Studies
- interferon and immune responses
- Gastrointestinal Tumor Research and Treatment
- Prostate Cancer Treatment and Research
- Herpesvirus Infections and Treatments
- Pharmacological Effects and Toxicity Studies
- Nanoplatforms for cancer theranostics
- Thermodynamic and Exergetic Analyses of Power and Cooling Systems
- Urologic and reproductive health conditions
- Vascular anomalies and interventions
- Drug Transport and Resistance Mechanisms
- Advanced Thermodynamic Systems and Engines
- NF-κB Signaling Pathways
- Viral-associated cancers and disorders
- Cancer-related Molecular Pathways
Changhai Hospital
2009-2023
Second Military Medical University
2009-2023
Naval Medical Research Command
2022
Glasgow Royal Infirmary
2016
Saudi Center for Organ Transplantation
2008
Until recently, there have been limited options for patients with bone metastatic castration-resistant prostate cancer (BmCRPC) following the failure of or development resistance to docetaxel (DTX), which is one frontline treatments.Sterol regulatory element-binding protein 1 (SREBP1) reported regulate abnormal lipid metabolism and promote progression metastasis (PCa).The siRNA interferes SREBP1 may provide an efficient treatment when combined DTX.Methods: In this study, lipoic acid (LA)...
Abstract Objective To investigate the safety and feasibility of using a novel purpose-built single-port robotic system (the SHURUI Robotic Surgical System) with deformable surgical instruments to perform retroperitoneal partial nephrectomy. Materials methods A prospective study was conducted recruit patients single renal tumor no more than 4 cm. Robot-assisted nephrectomy performed by instruments. Patients’ demographics, characteristics, perioperative parameters were recorded analyzed....
KLF11 is a negative regulator of CSC stemness in sarcoma by repressing YAP/TEAD-dependent transcription.
RING finger protein 7 (RNF7) is a highly conserved that functions as an E3 ubiquitin ligase. RNF7 overexpression indicated in multiple human cancers, but its role renal cell carcinoma (RCC) and the mechanisms underlying how it regulates initiation progression of RCC have not been explored. Bioinformatics analysis, quantitative reverse-transcription polymerase chain reaction (RT-PCR), Western blot were conducted to determine expression tissues lines. Knockdown experiments performed examine...
This prospective single-arm clinical trial aimed to evaluated the feasibility and safety of application SHURUI system, a novel purpose-built robotic in single-port radical prostatectomy. Sixteen patients diagnosed with prostate cancer were prospectively enrolled received prostatectomy from October 2021 August 2022. The demographic baseline data, surgical, oncological, functional outcomes as well follow-up data recorded. mean operative time was 226.3 (SD: 52.0) min, console 183.4 (SD 48.3) an...
Abstract Background The tripartite motif (TRIM) family proteins exhibit oncogenic roles in various cancers. of TRIM27, a member the TRIM super family, renal cell carcinoma (RCC) remained unexplored. In current study, we aimed to investigate clinical impact and TRIM27 development RCC. Methods mRNA levels Kaplan–Meier survival RCC were analyzed from Cancer Genome Atlas database. Real-time PCR Western blotting used measure protein both vivo vitro. siRNA exogenously overexpressed lines...
Clear cell renal carcinoma (ccRCC) with venous tumor thrombus (VTT) is associated poor prognosis. Our integrative analyses of transcriptome and proteome reveal distinctive molecular features ccRCC VTT, yield the development a prognostic classifier to facilitate subtyping treatment. The RNA sequencing mass spectrometry were performed in normal-tumor-thrombus tissue triples five patients. Statistical analysis, GO KEGG enrichment protein-protein interaction network construction used interpret...
This study aimed to assess the feasibility and safety of SHURUI single-port robotic surgical system for a range major urological surgeries. In this prospective, multicenter clinical trial, we examined effectiveness in interventions. The first 50 patients from four centers China underwent surgeries including partial nephrectomy, radical prostatectomy, adrenalectomy, pyeloureteroplasty, exclusively by system. study's primary endpoints focused on success surgeries, gauging absence deviations...
Clear cell renal carcinoma (ccRCC) patients with venous tumor thrombus (VTT) have poor prognosis. We aimed to reveal features of ccRCC VTT and develop a urine-based prognostic classifier predict prognosis through integrative analyses transcriptomic landscape urinary signature.RNA sequencing was performed in five thrombus-tumor-normal tissue triples, while mass spectrometry for urine samples from 12 11 healthy controls. A consisting three proteins developed patients' survival validated an...
Abstract Background To describe the techniques and outcomes of complete transperitoneal laparoscopic nephroureterectomy (CTLNU) for upper urinary tract urothelial carcinoma (UTUC) in a single position. Materials methods Those patients with localized UTUC were included, among which 50 cases had CTLNU while 48 open bladder cuff excision (LNOBE). The clinical data collected analyzed retrospectively. Results All 98 underwent successful procedures radical without transferring into surgery. No...
Patients with clinical T1-2 renal cell carcinoma (RCC) upstaging to pathological T3 showed worse survival prognosis than those without upstaging. We aimed develop and validate a morphology-based nephrometry scoring system for predicting of RCC.We retrospectively reviewed 200 patients RCC who underwent surgical treatment. The scores were measured through preoperative computed tomography images. risk factors identified by logistic regression models. predictive accuracy novel (M-Index), was...
Background: Kidney transplant recipients on long-term cyclosporine (CsA) therapy may develop multiple adverse drug events, and immunosuppression conversion from CsA to tacrolimus (Tac) is an option. Genetic variations, especially cytochrome P450 ( CYP ) 3A5*3 , affects Tac dosing. However, little information available guide the with regards patients' pharmacogenomics. We aimed investigate whether CYP3A5 CYP3A4 ABCB1 genotyping could contribute a more precise individualized initial dosing of...
Urologists still encounter challenges when it comes to the surgical management of tumors located on posterior lip and renal hilar region. We propose a trans-retro-peritoneal (TRP) technique address difficulties associated with during retroperitoneal laparoscopic partial nephrectomy (LPN). Its efficacy was evaluated in retrospective case-control study.The patients (≤7 cm) that underwent LPN were included. The TRP allowed tumor completely visible by incising ventral peritoneum rotating kidney...
There is especial request for medical ethics of urology which different from other dis-ciplines. Medical ethical education must be paid equal attention to expertise culture. And suitable guide wrong value. Practice suggested that we should do as follows : strictch by word and deed the first set an example ; think trans- enrich teaching form strengthen effects studying. Key words: Urology ; Undergraduates Ethical
Laparoendoscopic single-site (LESS) surgery is performed to further narrow the incisions and reduce tissue injury. It has been more than10 years since was first described. However, there still no report on results of 10-year follow-up. This study evaluated use long-term oncology renal outcomes LESS radical nephrectomy (LESS-RN) in treatment localized cancer.We retrospectively analyzed clinical data patients treated with LESS-RN at Changhai Hospital from 2009 2012. Patients kidney cancer who...